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In brief: Variation between strains may account for differences in people’s vulnerability to infection

Scientists have long sought to explain why people respond differently to bacterial infections. In the case of TB, for example, less than 10 percent of those infected with Mycobacterium tuberculosis develop severe lung disease, while others remain symptom-free.

In some cases, genetic defects have been shown to make the human immune system susceptible to infection. Yet human genetics may not be the whole story, according to research published today in PLOS Pathogens. It suggests that variations among strains within a single bacterial species may also provoke varied immune responsiveness in their human hosts. This variability is mainly contributed by viruses that infect bacteria.

Uri Sela, a clinical fellow in the laboratory of Vincent A. Fischetti, obtained these findings by analyzing blood samples from healthy volunteers whose immune cells had been challenged with different strains of Staphylococcus aureus. In many other studies, however, scientists have drawn conclusions about the immune system’s interactions with a bacterium based on experiments with a single strain, which may not be representative of the species as a whole, Sela says.

“Our findings are novel and unexpected,” he notes, “and may set the stage for better ways to predict a patient’s disease outcome and tailor treatment accordingly.”

vincent fischetti

Vincent A. Fischetti
Laboratory of Bacterial Pathogenesis and Immunology
Professor

Investigates bacterial infectious disease and the use of phage enzymes and their derivatives to block infection.


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