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Stem cell model offers first glimpse of early human development

The new platform’s ethically grounded approach promises to reveal much about how human embryos form during the earliest stages of pregnancy.

Theoretical physicist Carlo Rovelli to receive 2024 Lewis Thomas Prize

The author of There Are Places in the World Where Rules Are Less Important Than Kindness will be presented with Rockefeller’s prestigious science writing award on April 9.

The SNF Institute for Global Infectious Disease Research announces new advisory board

SNFiRU, which aims to better understand the agents that cause infectious disease and to lower barriers to treatment and prevention globally, launched numerous initiatives in its inaugural year.

New Mtb study offers a novel paradigm for understanding bacterial transcription

A novel sequencing technique reveals a genetic trick TB may be using to evade the immune system and resist antibiotics.

A pioneering way to target the culprit behind a deadly liver cancer

Researchers have translated a cutting-edge tactic for treating genetic disorders into a fresh approach for potentially stymying cancer.  

Vitamin A may play a central role in stem cell biology and wound repair

Retinoic acid, the active state of Vitamin A, appears to regulate how stem cells enter and exit a transient state central to their role in wound repair.

New study on mating behaviors offers clues into the evolution of attraction

In examining the mating rituals of roundworms, researchers uncovered a unique approach to reproduction that maximizes genetic fitness.

Universal tool for tracking cell-to-cell interactions

uLIPSTIC, an updated method for directly observing physical interactions between cells, could allow scientists to one day map every possible cell interaction.

Innovative microscopy tech answers fundamental questions

A powerful tool captures data from an unprecedented 1 million neurons simultaneously, painting a much fuller picture of brain dynamics.

Rogue enzymes cause numerous diseases. A new method could help design drugs to treat them.

A novel platform allows researchers to directly target enzymes implicated in infectious diseases, several genetic disorders, and some cancers for the first time.

David J. Lyons, former vice president for business and finance, has passed away

Known for his dedication, keen financial sense, and community spirit, Lyons served the university for decades.

Karl Palmquist wins 2024 Weintraub Graduate Student Award

Palmquist receives the honor for developing innovative methods to study mechanical forces and emergent phenomena in early organ development.

Svetlana Mojsov named 2024 recipient of the Pearl Meister Greengard Prize

Mojsov's research into hormonal triggers for insulin production led to groundbreaking treatments for diabetes and obesity. She will be presented with the award on April 17.

Double trouble at chromosome ends

The end replication problem dictates that telomeres shrink unless telomerase intervenes. But the problem is actually twice as complicated, with telomerase providing only part of the solution.

Cutting-edge methods yield surprising insights into Huntington’s disease

New findings add depth to our understanding of neurodegeneration.

Keeping telomerase in check

Telomerase could run amok, deleteriously capping damaged DNA, were it not for a first responder to DNA damage.

Luciano Marraffini wins Vilcek Prize in Biomedical Science

Marraffini is honored for his pioneering research on the study of CRISPR-Cas systems.

How fruit flies control the brain's "steering wheel"

A newly discovered neural circuit mediates between navigational brain cells, acting as a sort of mental steering wheel. 

Newly discovered genetic malfunction causes rare lung disease

The absence of a single immune cell receptor has been linked to both fewer defenses against mycobacterial infections, such as TB, and damaging buildup of sticky residue in the lungs.  

"Exhausted" immune cells may drive Alzheimer's

A class of ineffective immune cells may be driving Alzheimer’s disease, a finding that could both explain why APOE4 gene increases the risk of the disease and why a new drug can impact it.

Revealing how an ancient genetic invader inhabits our DNA

LINE-1 is associated with disease and aging. The Rout lab has uncloaked the core of its key protein, pointing the way towards therapeutic targets.

Yvena Bouillon, the assistant director of e-procurement and inventory control, has died

She was known by her colleagues for both her committed professionalism and her generous spirit.

A CRISPR pioneer looks back as the first gene-editing therapy is approved

Luciano Marraffini’s research helped lay the groundwork for the newly FDA-approved CRISPR-based therapy for sickle cell anemia. He reflects on how we got here—and where the science is going next.

Innovative method identifies rare brain cell types for the first time

It also reduces the cost of a million single-cell transcriptomes from $10,000 to $700—and the time necessary down to about a day.

A new way of thinking about how organ architecture develops 

By focusing on the emergent features of cell collectives, instead of individual cells, scientists forge a new path for understanding how organs develop their architecture.   

Intriguing science discoveries of 2023

From plumbing the depths of wound repair to tackling how songbirds solve problems, here are some fascinating discoveries that came out of Rockefeller in 2023.

Rockefeller launches startup incubator

Carlo Yuvienco, the inaugural director of the university’s new Ford Center Incubator, on how the new space will help translate research breakthroughs into market-ready biomedical innovations.

Her scientific breakthrough took 5 years. Getting credit took decades.

Mojsov’s research directly led to blockbuster drugs like Ozempic and Wegovy. She talks about the long quest for proper credit and lessons that can be learned from her experience.

How bacteria recognize viral invasion and activate immune defenses

Bacteria have an array of strategies to counter viral invasion, but how they first spot a stranger in their midst has long been a mystery.

How the antioxidant glutathione keeps mitochondria healthy

“I believe this is going to be a very fruitful find. Every time people have studied nutrient sensing, we’ve learned a lot about biology, and many drugs have been developed as a result.”
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