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The clearest snapshot of human genomic diversity ever taken

The human reference genome has always been a remarkable but flawed tool. A new "pangenome" aims to correct its oversights and omissions.

Behind the formation and protection of microtubules

Research shed light on the process by which the γ-Tubulin Ring Complex stabilizes microtubules, which may inform the study of developmental diseases and cancers.

Solving the mystery behind how nutrients enter cells

A new paper describes how choline is transported into the cell, with potentially sweeping implications for the study of rare diseases.

Maybe the virus isn't the problem 

Why do some with COVID end up on ventilators while others get a scratchy throat—and yet others seem to have dodged the virus entirely? Answers are emerging from scientists around the globe.

Researchers reveal an ancient mechanism for wound repair

The study is the first to identify a damage response pathway that is distinct from but parallel to the classical pathway triggered by pathogens.

Gum disease may lie at the root of some arthritis flare-ups

Damaged gums may release bacteria into the bloodstream that trigger arthritis flare-ups, potentially explaining why people with gum disease don't respond as well to arthritis treatments.

How to end a pandemic in one jab 

Universal vaccines can give years of protection against polio, measles, and smallpox, among other diseases. Pamela Bjorkman believes HIV, influenza, and COVID are next.

New tool to study hepatitis B could open the door to a cure

Just as the Rice lab’s work on HCV exposed that virus’s weaknesses, the hope is that this novel approach could do the same for HBV.

Seeking the origin story of de novo genes

Li Zhao studies the intriguing genes that emerge from previously silent or non-coding stretches of DNA.

Scientists discover brain region linking short-term to long-term memory

The anterior thalamus plays such a key role in memory that boosting it in mice consolidates the animals' trivial experiences into long-term memories.

What you get is not just what you see 

Scientists have built a novel AI system that rewrites the rules for computer vision. It might soon turn neuroscience on its head.

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New technique captures unprecedented view of the active brain

The tech, dubbed MesoLF, captures 10,500 neurons buried at once-inaccessible depths, firing from brain regions many millimeters apart, simultaneously—all with unprecedented resolution.

Pioneering forestry researcher Suzanne Simard to receive the 2023 Lewis Thomas Prize

The author of Finding the Mother Tree: Discovering the Wisdom of the Forest will be presented with Rockefeller’s prestigious science writing award on April 17.

Innovative approach opens the door to COVID nanobody therapies

The relatively simple and low-cost procedure could empower laboratories in low-resource areas to generate nanobodies against SARS-CoV-2, as well as other viruses.

Illuminating the evolution of social parasite ants

The findings offer a new way to understand how some ants become total layabouts.

Emil C. Gotschlich, creator of lifesaving vaccines, has died

A molecular chemist whose work has protected millions of people from bacterial meningitis, Gotschlich passed away on February 14. He was 88.

Homing in on the genetics of severe COVID in children

A trio of faulty genes fail to put the brakes on the immune system’s all-out assault on SARS-CoV-2, leading to the inflammatory overload characteristic of MIS-C.

The nutrient that cancer cells crave

Starving cancer cells of a key amino acid could potentially render tumors more vulnerable to the body’s natural immune response.

Elaine Fuchs awarded Benjamin Franklin Medal in Life Science

Fuchs receives the honor for illuminating the genetics of skin diseases and the mechanisms that guide skin renewal, yielding insights into aging, inflammation, and cancer.

A unique window into "original antigenic sin"

The body's first blush with a pathogen shapes how it will respond to vaccines. New evidence clarifies how this phenomenon works, mechanistically.

How the body's B cell academy ensures a diverse immune response

A diverse immune response hinges on naive B cells mingling with high affinity ones in the late-stage germinal center. Whether that helps or hinders, however, depends on the virus.

Remembering a pioneer of chromatin biology

Charles David Allis, a molecular biologist who shaped the field of chromatin biology, died on January 8 at the age of 71.

Why older fathers pass on more genetic mutations to their offspring

It's not just the number of mutations that matters. It's the failure to fix them too.

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Solving a crucial bottleneck in drug discovery

A novel method reduces the time required to identify novel antibiotic-producing DNA from weeks to days.

When the body's B cell training grounds stay open after hours

While most germinal centers shut down after a few weeks, some stay in business for more than six months. A new study helps explain why.

Intriguing science discoveries of 2022

Breakthroughs in genetics, biochemistry, neuroscience, infectious disease, and drug development were a few of the year's highlights.

Markus Library prepares researchers for new NIH data management policy

The library is offering new tools and training to support researchers operating under an updated NIH policy.

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How a cell's mitochondria make their own protein factories

The findings shed a rare light on mitoribosomes, the unique ribosomes found within the cell's mitochondria.

How antibody therapy impacts COVID vaccines

People who receive monoclonal antibodies before vaccines may benefit from increased coverage, due to antibody feedback inhibition.

Research on rare genetic disease sheds light on a common head and neck cancer

Patients with Fanconi anemia have an elevated risk for squamous cell carcinoma, a highly aggressive head-and-neck cancer. New findings pinpoint the mechanisms linking the two conditions, and also shed new light on how smoking or drinking may elevate anyone’s cancer risk.