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Why a promising breast cancer drug doesn’t work—and how to improve it
A treatment that appears effective in cancers such as myelofibrosis consistently fails in breast cancer clinical trials. A new study explains why.
Cancer cells may be using lipids to hide from the immune system
New study demonstrates that one type of lipid is so critical for immune evasion that certain cancers cannot proliferate without them. Modulating intake of dietary lipids could open up an avenue for treatment.
New findings on TB could change how we treat inflammatory disorders    
The study explains why treatments for many autoimmune and inflammatory diseases raise the risk of contracting TB—and also upends long-held assumptions about what kicks off an immune response.      
This technique for studying cell receptors could have sweeping implications for drug development
Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors.
New insight into the protein mutations that cause Rett syndrome
Findings bolster the idea that the functions of this protein—MeCP2—are more centered on nucleosomes, rather than other forms of DNA.
Second genetic sensor for DNA methylation discovered
CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA.
Surprising mechanism for removing dead cells identified
A tandem signaling process turns ordinary cells into an efficient cleanup crew.
Peter Chin, a computer support specialist and authority on Apple technology, has died
A Rockefeller employee since 2001, Chin will be missed by many in the community who came to rely on his deep technical expertise and graceful approach to problem solving.
Knocking out one key gene leads to autistic traits
Hyperactivity, repetitive behavior, and language deficits all appeared in the mice, highlighting an unexpected role the cerebellum seems to play in autism.
Many people with severe brain injuries are far more cognitively aware than they seem
Rockefeller University Hospital developed a model clinical infrastructure for the study, as well as helped conduct it.
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