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Found 34923 matches. Displaying 31-40
Laurin M
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An RNAi screen unravels the complexities of Rho GTPase networks in skin

ELIFE 2019 SEP 25; 8(?):? Article e50226
During mammalian embryogenesis, extensive cellular remodeling is needed
Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S
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Force-induced conformational changes in PIEZO1

NATURE 2019 SEP 12; 573(7773):230-234
PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals. Partial molecular structures show that PIEZO1 is a bowl-shaped trimer with extended arms. Here we use cryo-electron microscopy to show that PIEZO1 adopts different degrees of curvature in lipid vesicles of different sizes. We also use high-speed atomic force microscopy to analyse the deformability of PIEZO1 under force in membranes on a mica surface, and show that PIEZO1 can be flattened reversibly into the membrane plane. By approximating the absolute force applied, we estimate a range of values for the mechanical spring constant of PIEZO1. Both methods of microscopy demonstrate that PIEZO1 can deform its shape towards a planar structure. This deformation could explain how lateral membrane tension can be converted into a conformation-dependent change in free energy to gate the PIEZO1 channel in response to mechanical perturbations
Nasca C
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Multidimensional Predictors of Susceptibility and Resilience to Social

BIOLOGICAL PSYCHIATRY 2019 SEP 15; 86(6):483-491
BACKGROUND: Previous studies identified several separate risk factors
Martyn I
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Mapping cell migrations and fates in a gastruloid model to the human

DEVELOPMENT 2019 SEP 1; 146(17):? Article UNSP dev179564
Although fate maps of early embryos exist for nearly all model
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INTRACELLULAR ORGANIZATION Getting ready for DNA duplication

ELIFE 2019 SEP 27; 8(?):? Article e51291
The discovery of a biomolecular condensate involved in DNA replication
Hernandez N
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Inherited IFNAR1 deficiency in otherwise healthy patients with adverse

Vaccination against measles, mumps, and rubella (MMR) and yellow fever
Islam MS
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Application of a Phage Cocktail for Control of Salmonella in Foods and

VIRUSES-BASEL 2019 SEP; 11(9):? Article 841
Salmonella contamination in foods and their formation of biofilms in
Kim GB, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Abbasi Akhtar A, Linesch PW, Kobritz N, Chandra SS, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau DS, Filbin MG, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva ML, Chen B, Danielpour M, Breunig JJ
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Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements

CELL 2019 SEP 19; 179(1):251-267.e24
In situ transgenesis methods such as viruses and electroporation can rapidly create somatic transgenic mice but lack control over copy number, zygosity, and locus specificity. Here we establish mosaic analysis by dual recombinase-mediated cassette exchange (MADR), which permits stable labeling of mutant cells expressing transgenic elements from precisely defined chromosomal loci. We provide a toolkit of MADR elements for combination labeling, inducible and reversible transgene manipulation, VCre recombinase expression, and transgenesis of human cells. Further, we demonstrate the versatility of MADR by creating glioma models with mixed reporter-identified zygosity or with "personalized" driver mutations from pediatric glioma. MADR is extensible to thousands of existing mouse lines, providing a flexible platform to democratize the generation of somatic mosaic mice
Duvall LB
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Mosquito Host-Seeking Regulation: Targets for Behavioral Control

TRENDS IN PARASITOLOGY 2019 SEP; 35(9):704-714
Female Aedes aegypti mosquitoes require protein from blood to develop
Green J
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A neural heading estimate is compared with an internal goal to guide

NATURE NEUROSCIENCE 2019 SEP; 22(9):1460-1468
Goal-directed navigation is thought to rely on the activity of