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Found 34923 matches. Displaying 41-50
Braunberger TL
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Hemoglobin as an indicator of disease activity in severe hidradenitis

INTERNATIONAL JOURNAL OF DERMATOLOGY 2019 SEP; 58(9):1090-1091
Wang MX
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Contributions of Rare Gene Variants to Familial and Sporadic FSGS

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2019 SEP; 30(9):1625-1640
Background Over the past two decades, the importance of genetic factors
Puel A
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The nature of human IL-6

JOURNAL OF EXPERIMENTAL MEDICINE 2019 SEP; 216(9):1969-1971
Attner MA
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HLH-2/E2A Expression Links Stochastic and Deterministic Elements of a

CURRENT BIOLOGY 2019 SEP 23; 29(18):3094-3100.e4
Stochastic mechanisms diversify cell fate in organisms ranging from
Weitzenfeld P
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Antibodies targeting sialyl Lewis A mediate tumor clearance through

JOURNAL OF CLINICAL INVESTIGATION 2019 SEP 3; 129(9):3952-3962
Sialyl Lewis A (sLeA, also known as CA19-9), a tetrasaccharide
Alushin G
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Early Career Advisory Board

JOURNAL OF CELL BIOLOGY 2019 SEP; 218(9):2813-2814
Wang TT
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Functional diversification of IgGs through Fc glycosylation

JOURNAL OF CLINICAL INVESTIGATION 2019 SEP 3; 129(9):3492-3498
IgG antibodies are secreted from B cells and bind to a variety of
Marat A
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Early Career Advisory Board: Q&A on career and publishing

JOURNAL OF CELL BIOLOGY 2019 SEP; 218(9):2815-2818
We interviewed our Early Career Advisory Board to learn about their
Laurin M
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An RNAi screen unravels the complexities of Rho GTPase networks in skin

ELIFE 2019 SEP 25; 8(?):? Article e50226
During mammalian embryogenesis, extensive cellular remodeling is needed
Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S
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Force-induced conformational changes in PIEZO1

NATURE 2019 SEP 12; 573(7773):230-234
PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals. Partial molecular structures show that PIEZO1 is a bowl-shaped trimer with extended arms. Here we use cryo-electron microscopy to show that PIEZO1 adopts different degrees of curvature in lipid vesicles of different sizes. We also use high-speed atomic force microscopy to analyse the deformability of PIEZO1 under force in membranes on a mica surface, and show that PIEZO1 can be flattened reversibly into the membrane plane. By approximating the absolute force applied, we estimate a range of values for the mechanical spring constant of PIEZO1. Both methods of microscopy demonstrate that PIEZO1 can deform its shape towards a planar structure. This deformation could explain how lateral membrane tension can be converted into a conformation-dependent change in free energy to gate the PIEZO1 channel in response to mechanical perturbations