Skip to main content
!
Emergency notification: The campus is closed except to essential personnel and those conducting approved critical lab operations or approved COVID-19 research. Updates here.

Publications search

Found 35038 matches. Displaying 91-100
Kitzler TM
Show All Authors

COL4A1 mutations as a potential novel cause of autosomal dominant CAKUT

HUMAN GENETICS 2019 OCT; 138(10):1105-1115
Congenital anomalies of the kidney and urinary tract (CAKUT) are the
Sirunyan AM
Show All Authors

Evidence for light-by-light scattering and searches for axion-like

PHYSICS LETTERS B 2019 OCT 10; 797(?):? Article UNSP 134826
Evidence for the light-by-light scattering process, gamma gamma -> gamma
Bournazos S
Show All Authors

Differential requirements for Fc gamma R engagement by protective

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 2019 OCT 1; 116(40):20054-20062
Ebola virus (EBOV) continues to pose significant threats to global
Rosain J
Show All Authors

LINE-1-Mediated AluYa5 Insertion Underlying Complete Autosomal Recessive

JOURNAL OF CLINICAL IMMUNOLOGY 2019 OCT; 39(7):739-742
Li Y, Levran O, Kim J, Zhang TJ, Chen XD, Suo C
Show All Authors

Extreme sampling design in genetic association mapping of quantitative trait loci using balanced and unbalanced case-control samples

SCIENTIFIC REPORTS 2019 OCT 29; 9(?):? Article 15504
It is extremely expensive to conduct large sample size array- or sequencing based genome scale association studies. For a quantitative trait, an extreme case-control study design may improve the power and reduce the cost of variant calling. We investigated the performance of extreme study design when various proportions of samples are selected from the tails of phenotype distribution. Using simulations, we show that when risk genotypes become rare in the population and effect size is relatively small, it is beneficial to carry out an extreme sampling study. In particular, the number of selected cases and controls can even be unbalanced such that power is further increased, compared with a balanced selection. Our application to two data sets: methadone dose data and yearling weight data, demonstrated that similar results for full data analysis can be obtained using extreme sampling with only a fraction of the data. Using power analysis with simulated data and an experimental data application, we conclude that when full data is unavailable due to restricted budget, it is rewarding to employ an extreme sampling design in the sense that there can be immense cost reductions and qualitatively similar power as in the full data analysis.
Rostandy B
Show All Authors

Botanical metabolite ions extraction from full electrospray ionization

METABOLOMICS 2019 OCT; 15(10):? Article 136
Introduction Mass spectrometric data analysis of complex biological
Diehl KL, Ge EJ, Weinberg DN, Jani KS, Allis CD, Muir TW
Show All Authors

PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2019 OCT 29; 116(44):22152-22157
A lysine-to-methionine mutation at lysine 27 of histone 3 (H3K27M) has been shown to promote oncogenesis in a subset of pediatric gliomas. While there is evidence that this "oncohistone" mutation acts by inhibiting the histone methyltransferase PRC2, the details of this proposed mechanism nevertheless continue to be debated. Recent evidence suggests that PRC2 must simultaneously bind both H3K27M and H3K27me3 to experience competitive inhibition of its methyltransferase activity. In this work, we used PRC2 inhibitor treatments in a transgenic H3K27M cell line to validate this dependence in a cellular context. We further used designer chromatin inhibitors to probe the geometric constraints of PRC2 engagement of H3K27M and H3K27me3 in a biochemical setting. We found that PRC2 binds to a bivalent inhibitor unit consisting of an H3K27M and an H3K27me3 nucleosome and exhibits a distance dependence in its affinity for such an inhibitor, which favors closer proximity of the 2 nucleosomes within a chromatin array. Together, our data precisely delineate fundamental aspects of the H3K27M inhibitor and support a model wherein PRC2 becomes trapped at H3K27M-H3K27me3 boundaries.
Goncalves BV
Show All Authors

Role of MurT C-Terminal Domain in the Amidation of Staphylococcus aureus

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2019 OCT; 63(10):? Article e00957-19
Glutamate amidation, a secondary modification of the peptidoglycan, was
Dosenovic P
Show All Authors

Anti-idiotypic antibodies elicit anti-HIV-1-specific B cell responses

JOURNAL OF EXPERIMENTAL MEDICINE 2019 OCT; 216(10):2316-2330
Human anti-HIV-1 broadly neutralizing antibodies (bNAbs) protect against
Bubnys A, Kandel H, Kao LM, Pfaff D, Tabansky I
Show All Authors

Hindbrain V2a Neurons Pattern Rhythmic Activity of Motor Neurons in a Reticulospinal Coculture

FRONTIERS IN NEUROSCIENCE 2019 OCT 17; 13(?):? Article 1077
As the capacity to isolate distinct neuronal cell types has advanced over the past several decades, new two- and three-dimensional in vitro models of the interactions between different brain regions have expanded our understanding of human neurobiology and the origins of disease. These cultures develop distinctive patterns of activity, but the extent that these patterns are determined by the molecular identity of individual cell types versus the specific pattern of network connectivity is unclear. To address the question of how individual cell types interact in vitro, we developed a simplified culture using two excitatory neuronal subtypes known to participate in the in vivo reticulospinal circuit: HB9(+) spinal motor neurons and Chx10(+) hindbrain V2a neurons. Here, we report the emergence of cell type-specific patterns of activity in culture; on their own, Chx10(+) neurons developed regular, synchronized bursts of activity that recruited neurons across the entire culture, whereas HB9(+) neuron activity consisted of an irregular pattern. When these two subtypes were cocultured, HB9(+) neurons developed synchronized network bursts that were precisely correlated with Chx10(+) neuron activity, thereby recreating an aspect of Chx10(+) neurons' role in driving motor activity. These bursts were dependent on AMPA receptors. Our results demonstrate that the molecular classification of the neurons comprising in vitro networks is a crucial determinant of their activity. It is therefore possible to improve both the reproducibility and the applicability of in vitro neurobiological and disease models by carefully controlling the constituent mixtures of neuronal subtypes.