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Found 34923 matches. Displaying 51-60
Roeder RG
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50+years of eukaryotic transcription: an expanding universe of factors

NATURE STRUCTURAL & MOLECULAR BIOLOGY 2019 SEP; 26(9):783-791
The landmark 1969 discovery of nuclear RNA polymerases I, II and III in
Puel A
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The nature of human IL-6

JOURNAL OF EXPERIMENTAL MEDICINE 2019 SEP; 216(9):1969-1971
Nasca C
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Multidimensional Predictors of Susceptibility and Resilience to Social

BIOLOGICAL PSYCHIATRY 2019 SEP 15; 86(6):483-491
BACKGROUND: Previous studies identified several separate risk factors
Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S
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Force-induced conformational changes in PIEZO1

NATURE 2019 SEP 12; 573(7773):230-234
PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals. Partial molecular structures show that PIEZO1 is a bowl-shaped trimer with extended arms. Here we use cryo-electron microscopy to show that PIEZO1 adopts different degrees of curvature in lipid vesicles of different sizes. We also use high-speed atomic force microscopy to analyse the deformability of PIEZO1 under force in membranes on a mica surface, and show that PIEZO1 can be flattened reversibly into the membrane plane. By approximating the absolute force applied, we estimate a range of values for the mechanical spring constant of PIEZO1. Both methods of microscopy demonstrate that PIEZO1 can deform its shape towards a planar structure. This deformation could explain how lateral membrane tension can be converted into a conformation-dependent change in free energy to gate the PIEZO1 channel in response to mechanical perturbations
Krueger JG
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IL-17A inhibition by secukinumab induces early clinical,

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2019 SEP; 144(3):750-763
Background: Hyperactivity of the IL-23/IL-17 axis is central to plaque
Alushin G
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Early Career Advisory Board

JOURNAL OF CELL BIOLOGY 2019 SEP; 218(9):2813-2814
Pisa R
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Analyzing Resistance to Design Selective Chemical Inhibitors for AAA

CELL CHEMICAL BIOLOGY 2019 SEP 19; 26(9):1263-1273.e5
Drug-like inhibitors are often designed by mimicking cofactor or
Laurin M
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An RNAi screen unravels the complexities of Rho GTPase networks in skin

ELIFE 2019 SEP 25; 8(?):? Article e50226
During mammalian embryogenesis, extensive cellular remodeling is needed
McEwen BS
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The good side of "stress"

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 2019 SEP 3; 22(5):524-525
Stress has both a good and bad side which are discussed in terms of the
Duvall LB
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Mosquito Host-Seeking Regulation: Targets for Behavioral Control

TRENDS IN PARASITOLOGY 2019 SEP; 35(9):704-714
Female Aedes aegypti mosquitoes require protein from blood to develop