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Displaying 125 of 2850 articles.

Exploring genetic “dark matter,” researchers gain new insights into autism and stroke

For the brain to function smoothly, its cells must carefully regulate which proteins are produced and when. By studying gene regulation, researchers are now shedding light on complex brain conditions like autism and stroke.

Hinge-like protein may open new doors in cystic fibrosis treatment

Drugs known as potentiators alleviate some symptoms of cystic fibrosis. Researchers recently figured out how these compounds work—a finding that may lead to better drugs that patients can more easily afford.

Learning from experience is all in the timing

Animals learn the hard way which sights, sounds, and smells are relevant to survival. New research in flies shows that the timing of these cues plays an important role in how mental associations arise, and elucidates brain pathways involved in this process.

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New molecular diagnostics test could help guide lupus treatments

A tool that detects glitches in gene expression could help doctors tailor treatments for lupus-related kidney damage.

New compounds could be used to treat autoimmune disorders

In autoimmune disorders, the body’s defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions.

New hope for treating a childhood brain cancer

Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors.

New approach to treating gastrointestinal disease patches up leaky intestines

Researchers have discovered a new compound that helps fortify the intestine's inner lining, which becomes porous in inflammatory bowel diseases.  

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New tool allows scientists to catch elusive protein in action

Scientists still have a lot to learn about the processes that trigger cell division, partly because they happen so quickly. A new chemical probe will make it possible to capture the workings of one of the key players.

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Researchers discover a common link among diverse cancer types

Some cancers have been traced to changes in histones, proteins responsible for packaging DNA and regulating genes. Now, research from Rockefeller scientists shows that, among tumors, mutations to these proteins are a lot more common than previously suspected.

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Enzyme structure reveals how DNA is opened up for transcription

DNA’s two strands must be separated before its code can be read, or transcribed. By studying the structure of the enzyme RNA polymerase, researchers have elucidated how DNA unwinds and becomes legible.