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Science News

New structural studies reveal workings of a molecular pump that ejects cancer drugs

Sometimes cells resist medication by spitting it back out. Cancer cells, in particular, have a reputation for defiantly expelling the chemotherapy drugs meant to kill them. Researchers at The Rockefeller University have shed new light on a molecular pump that makes this possible, by determining i...
Awards and Honors

Howard C. Hang receives 2017 Eli Lilly Award in Biological Chemistry

Howard C. Hang, Richard E. Salomon Family Associate Professor and head of the Laboratory of Chemical Biology and Microbial Pathogenesis, has won the 2017 Eli Lilly Award in Biological Chemistry. The prize, given by the American Chemical Society, recognizes outstanding research in biological chemi...
Science News

Atomic-scale view of bacterial proteins offers path to new tuberculosis drugs

With the first detailed analysis of a cellular component from a close relative of the pathogen that causes tuberculosis, Rockefeller scientists are suggesting strategies for new drugs to curb this growing health problem. Each year, nearly half a million people around the world are infected with m...
The structure unveiled that part of the helicase known as the N-tier travels ahead of the C-tier along the leading DNA strand
Science News

Study reveals the structure of a protein crucial for DNA replication

Our DNA contains instructions crucial for virtually all forms of life on this planet. But for life to propagate, this blueprint must be copied and passed on to future generations. New findings describing the structure of a key molecule involved in DNA replication place another piece in the puzzle...
Science News

MacKinnon lab charts the anatomy of three molecular channels

Using a state-of-the-art imaging technology in which molecules are deep frozen, scientists in Roderick MacKinnon’s lab at Rockefeller University have reconstructed in unprecedented detail the three-dimensional architecture of three channels that provide a path for specific types of ions to travel...
Awards and Honors

Biophysicist Gregory M. Alushin receives White House honor for early career scientists

Gregory M. Alushin, assistant professor and head of the Laboratory of Structural Biophysics and Mechanobiology, has been chosen by President Obama as one of 102 researchers to receive the Presidential Early Career Award for Scientists and Engineers, the highest honor given by the U.S. government ...
Science News

New molecular map reveals how cells spew out potassium

New research from Roderick MacKinnon's Laboratory of Molecular Neurobiology and Biophysics at The Rockefeller University has determined, for the first time, the complete structure of an ion channel that plays an important role in cellular electrical signaling by sending potassium ions out of the ...
Campus News

Pels Family Center for Biochemistry and Structural Biology receives new $10 million grant

by Alexandra MacWade, assistant editor A new $10 million endowment gift made by the Donald A. Pels Charitable Trust will provide ongoing support for the university’s chemical and structural biologists through the Pels Family Center for Biochemistry and Structural Biology. Mr. Pels, who was a Roc...
Science News

New structure shows how cells assemble protein-making machinery

Scientists at The Rockefeller University have created the most detailed three-dimensional images to date of an important step in the process by which cells make the nano-machines responsible for producing all-important protein. The results, described December 15 in Science, are prompting the rese...
Science News

First structural map of the cystic fibrosis protein sheds light on how mutations cause disease

Rockefeller scientists have created the first three-dimensional map of the protein responsible for cystic fibrosis, an inherited disease for which there is no cure. This achievement, described December 1 in Cell, offers the kinds of insights essential to better understanding and treating this oft...
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