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Enzyme structure helps to explain how protein factories are constructed

Researchers characterized the structure of Mdn1, an enzyme key to making ribosomes.

Sohail Tavazoie promoted to professor

Sohail Tavazoie, a physician-scientist who studies the genes that regulate a tumor’s ability to metastasize, has been promoted to professor.

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Structural studies help explain how cancer cells resist chemotherapy

New research sheds light on how some cancer cells use molecular pumps to expel chemotherapy drugs before they have a chance to work.

Scientists map the portal to the cell’s nucleus

The gateway to cellular headquarters has 552 components. A new map that shows how all these pieces fit together could help scientists study numerous diseases.

Scientists caution that a rare childhood liver cancer can spread to the brain

A new report details three cases of secondary brain tumors in people with fibrolamellar hepatocellular carcinoma. The researchers say imaging tests could improve treatment for patients whose cancer spreads to the brain from the liver.

Molecular doorstop could be key to new tuberculosis drugs

In discovering how an antibiotic kills the bacteria that cause tuberculosis, scientists open the door to new treatments for the disease—and possibly others, as well.

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Building the machinery that makes proteins

Scientists have used cryo-electron microscopy to capture the very first snapshots of the large ribosomal subunit—part of the ribosome responsible for forging bonds between amino acids, the building blocks of proteins—coming together.

Molecule discovered in dirt could help against multi-resistant bacteria

In mining soil for natural drugs, scientists have discovered a brand-new antibiotic potent against many bacteria. They hope it could be used to treat infections that cannot be stopped with existing drugs.

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In brief: Tweaking RNA protects cells from harmful inflammation

New research has helped explain what goes wrong in Aicardi-Goutières syndrome, a rare brain disorder. Patients with the disease have genetic abnormalities that may put their cells at risk of accidentally triggering an antiviral response.

Günter Blobel, a Nobel laureate who redefined cell biology, has died

Günter Blobel, a Nobel Prize-winning Rockefeller biologist who discovered the mechanisms by which proteins are targeted for delivery to specific locations within cells, died February 18 at 81.