News & HighlightsNews
New mechanism for maintaining genome stability discovered
New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli.
A new class of antivirals could help prevent future pandemics
Researchers discovered a vulnerability in viral enzymes that could lead to novel treatments for diseases as diverse as COVID and Ebola, while also minimizing side effects and reducing the odds of drug resistance.
Why a promising breast cancer drug doesn’t work—and how to improve it
A treatment that appears effective in cancers such as myelofibrosis consistently fails in breast cancer clinical trials. A new study explains why.
This technique for studying cell receptors could have sweeping implications for drug development
Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors.
New insight into the protein mutations that cause Rett syndrome
Findings bolster the idea that the functions of this protein—MeCP2—are more centered on nucleosomes, rather than other forms of DNA.
Second genetic sensor for DNA methylation discovered
CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA.
Researchers capture never-before-seen view of gene transcription
New tech reveals findings that address long-standing theories about how bacteria begin the process of making RNA from DNA.
Elizabeth Campbell launches Laboratory of Molecular Pathogenesis
The infectious disease specialist will continue her groundbreaking work on the transcriptomes of the pathogens behind tuberculosis and Covid.
How one scientist's fascination with RNA changed medicine forever
Thomas Tuschl has devoted his career to making discoveries that bridge the gap between bench and business—and have resulted in entirely new classes of drugs.
New Mtb study offers a novel paradigm for understanding bacterial transcription
A novel sequencing technique reveals a genetic trick TB may be using to evade the immune system and resist antibiotics.
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