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Displaying 136 of 2936 articles.
Building the machinery that makes proteins
Scientists have used cryo-electron microscopy to capture the very first snapshots of the large ribosomal subunit—part of the ribosome responsible for forging bonds between amino acids, the building blocks of proteins—coming together.
Molecule discovered in dirt could help against multi-resistant bacteria
In mining soil for natural drugs, scientists have discovered a brand-new antibiotic potent against many bacteria. They hope it could be used to treat infections that cannot be stopped with existing drugs.
In brief: Tweaking RNA protects cells from harmful inflammation
New research has helped explain what goes wrong in Aicardi-Goutières syndrome, a rare brain disorder. Patients with the disease have genetic abnormalities that may put their cells at risk of accidentally triggering an antiviral response.
Günter Blobel, a Nobel laureate who redefined cell biology, has died
Günter Blobel, a Nobel Prize-winning Rockefeller biologist who discovered the mechanisms by which proteins are targeted for delivery to specific locations within cells, died February 18 at 81.
New images reveal how the ear’s sensory hairs take shape
Our ability to hear relies on tiny bundles of hair-like sensors inside the inner ear. Scientists have identified a key component of the machinery that makes these bundles grow in an orderly fashion.
New immunotherapy approach boosts body’s ability to destroy cancer cells
A new treatment may help cancer patients who don't respond to traditional immunotherapy. Findings from the first-ever clinical trial reveal that it is effective in activating immune cells that kill cancer cells.
3D imaging of fat reveals potential targets for new obesity treatments
With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.
Neuroscientist Vanessa Ruta promoted to associate professor
Ruta, who explores how brains produce such flexible responses to fixed stimuli, has been promoted to Gabrielle H. Reem and Herbert J. Kayden associate professor.
New study points the way to therapy for rare cancer that targets the young
Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They’ve used it to clarify what drives these tumors at the molecular level, and discover new drug concepts.
Targeting a single protein might treat a broad range of viruses
Scientists have identified a protein that many viruses require to spread within a host—a discovery that could lead to fighting diseases as varied as parainfluenza, West Nile, and Zika with a single drug. This finding could also lead to the development of treatments for emerging viruses.
Potential new treatment for Fragile X targets one gene to affect many
Scientists found that inhibiting a regulatory protein alters the intricate signaling chemistry that is responsible for many of the disease’s symptoms. The findings provide a path to possible therapeutics for disorders associated with Fragile X.
Titia de Lange to receive 2017 Rosenstiel Award
de Lange is honored for her elucidation of the mechanism of telomere protection and the maintenance of genome stability.
Gut bacteria that “talk” to human cells may lead to new treatments
Scientists developed a method to genetically engineer gut bacteria to produce molecules that have the potential to treat certain disorders by altering human metabolism.
In brief: How a microRNA protects against liver cancer
New insights about gene regulation in liver cells could lead to better treatments for a common tumor type.
New animal models for hepatitis C could pave the way for a vaccine
In the rats that roam New York City’s streets and tunnels, scientists have found a virus that resembles hepatitis C. They have used it to create the first animal model of the human disease, a breakthrough that potentially could yield a much-needed vaccine.
In brief: A glimpse into the origins of antibiotic resistance
Scientists have identified several genetic mechanisms by which antibiotic resistance may have arisen in a bacterium that causes deadly infections.
A hidden movement in the molecule that makes RNA
Researchers have uncovered new details about the molecular machine that separates DNA strands before copying a gene's sequence into RNA.
In brief: Mapping the errors that disrupt heartbeat
By determining the structure of a protein linked to a deadly form of arrhythmia, scientists have gained new insights about the condition.
In brief: A closer look at why some drugs cause arrhythmia
Scientists have identified the features that render a potassium channel in the heart vulnerable to interference by a range of drugs.
C. David Allis wins 2017 March of Dimes Prize in Developmental Biology
Allis has received the March of Dimes Prize in Developmental Biology. The award, given to investigators whose research offers hope for the prevention and treatment of birth defects and other infant diseases, honors Allis for his groundbreaking work on gene regulation.
Discovery of a Zika antibody offers hope for a vaccine
Searching for a way to thwart Zika, scientists have discovered an antibody with a potent ability to neutralize the virus.
Shooting the messenger: how one protein allows germ cells to develop
Researchers have identified a molecule that guides the formation of eggs and sperm by preventing a host of factors related to cell death and inflammation from killing the precursors to these cells. Their findings reveal new knowledge about how a mutation in this molecule leads to male sterility.
New study resolves the structure of the human protein that causes cystic fibrosis
In order to better understand how genetic mutations give rise to cystic fibrosis, researchers need to map the protein responsible for the disorder. The new structure has led to new insights on how this molecular channel functions.
A new way to reset gene expression in cancer cells shows promise for leukemia treatment
New findings from Rockefeller University researchers could guide the development of potent combination therapies that deliver more effective and durable treatment of leukemia. In recent work published in Nature, they show it’s possible to deactivate cellular programs involved in tumor growth by d...
New structural studies reveal workings of a molecular pump that ejects cancer drugs
Sometimes cells resist medication by spitting it back out. Cancer cells, in particular, have a reputation for defiantly expelling the chemotherapy drugs meant to kill them. Researchers at The Rockefeller University have shed new light on a molecular pump that makes this possible, by determining i...
Howard C. Hang receives 2017 Eli Lilly Award in Biological Chemistry
Howard C. Hang, Richard E. Salomon Family Associate Professor and head of the Laboratory of Chemical Biology and Microbial Pathogenesis, has won the 2017 Eli Lilly Award in Biological Chemistry. The prize, given by the American Chemical Society, recognizes outstanding research in biological chemi...
Atomic-scale view of bacterial proteins offers path to new tuberculosis drugs
With the first detailed analysis of a cellular component from a close relative of the pathogen that causes tuberculosis, Rockefeller scientists are suggesting strategies for new drugs to curb this growing health problem. Each year, nearly half a million people around the world are infected with m...
Study reveals the structure of a protein crucial for DNA replication
Our DNA contains instructions crucial for virtually all forms of life on this planet. But for life to propagate, this blueprint must be copied and passed on to future generations. New findings describing the structure of a key molecule involved in DNA replication place another piece in the puzzle...
MacKinnon lab charts the anatomy of three molecular channels
Using a state-of-the-art imaging technology in which molecules are deep frozen, scientists in Roderick MacKinnon’s lab at Rockefeller University have reconstructed in unprecedented detail the three-dimensional architecture of three channels that provide a path for specific types of ions to travel...
Biophysicist Gregory M. Alushin receives White House honor for early career scientists
Gregory M. Alushin, assistant professor and head of the Laboratory of Structural Biophysics and Mechanobiology, has been chosen by President Obama as one of 102 researchers to receive the Presidential Early Career Award for Scientists and Engineers, the highest honor given by the U.S. government ...
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