Researchers discovered that a crucial first step in the signaling system operates differently than previously thought, an insight that could lead to the next generation of treatments.
Researchers found that pairing the antibiotic rifampicin with a second compound turned multidrug resistance into a weakness—providing proof of concept for using basic science to design life-saving dual-drug strategies.
Their newest technique has already uncovered hundreds of hidden bacterial genomes and two promising antibiotics. Now, the same approach could unlock an entire microbial universe—reshaping drug discovery and our understanding of how bacteria shape our environment.
Newly identified compounds appear effective against drug-resistant bacteria. The technique used to reveal them could uncover many more antibiotics, as well as help illuminate a previously hidden microbial world.
New research demonstrates that a previously published structure and mechanism for RNA capping at work in coronaviruses is incorrect, with potentially sweeping implications for the quest to develop drugs targeting these pathogens.
Mojsov is recognized for her discovery of the peptide hormone GLP-1, research that led to a new class of safe and highly effective drugs for type 2 diabetes as well as the treatment of obesity.
A collaboration between Rockefeller, MSK, and Weill Cornell answers a longstanding
mystery about the basic biology of the hepatitis B virus, while also proposing a novel therapy.
Male fruit flies don’t just sing to their mates; they also use sound-cancelling wing-flicks to jockey with rivals. This new understanding of how male flies compete for female partners could shed light on how the brain balances cooperation and competition.
Researchers discovered a vulnerability in viral enzymes that could lead to novel treatments for diseases as diverse as COVID and Ebola, while also minimizing side effects and reducing the odds of drug resistance.
Thomas Tuschl has devoted his career to making discoveries that bridge the gap between bench and business—and have resulted in entirely new classes of drugs.
By focusing on the emergent features of cell collectives, instead of individual cells, scientists forge a new path for understanding how organs develop their architecture.
In developing bird skin, immature cells move around and form intricate patterns. Scientists are zeroing in on the mechanical forces guiding the process.
Linker histone H1 appears capable of distinguishing between single-stranded and double-stranded DNA, suggesting that its role in maintaining our genomes extends far beyond that of keeping chromosomes compact.
The compound attacks MRSA, C. diff, and several other deadly pathogens. Its discovery demonstrates the power of combining computational biology, genetic sequencing, and synthetic chemistry to study bacterial evolution.
