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Displaying 126 of 2857 articles.
Science News

A compound that stops cells from making protein factories could lead to new antifungal drugs

Tiny, abundant biological factories, known as ribosomes, produce the cell’s most fundamental building material: protein. If ribosomes don’t work, cells can’t divide—and this can be an advantage for scientists seeking to develop drugs that target invading organisms, such as pathogenic fungi. ...
Awards and Honors

Four Rockefeller scientists named 2016 HHMI Faculty Scholars

Four Rockefeller University scientists—Daniel Kronauer, Luciano Marraffini, Agata Smogorzewska, and Sohail Tavazoie—have been named Howard Hughes Medical Institute Faculty Scholars. The Faculty Scholars program, a new collaboration between HHMI, the Simons Foundation, and the Bill & Melinda Gate...
Awards and Honors

Charles M. Rice wins Lasker Award for groundbreaking work on the hepatitis C virus

Charles M. Rice, Maurice R. and Corinne P. Greenberg Professor in Virology and head of the Laboratory of Virology and Infectious Disease, has been honored with the 2016 Lasker-DeBakey Clinical Medical Research Award, the country’s most prestigious science prize. Rice shares the award with Ralf F....
Science News

Four postdocs honored with 2016 Tri-Institutional Breakout Awards

NEW YORK, NY—Four young life scientists from Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medicine are the winners of the 2016 Tri-Institutional Breakout Awards for Junior Investigators. The awards, established last year by three winners of the 2013 Breakt...
Science News

Structural images shed new light on a cancer-linked potassium channel

    Most cells in the body carry on their surface tiny pores through which potassium ions travel. In controlling the flow of these positively charged ions, the channel helps the cell maintain its electrical balance. One particular type of potassium channel, called Eag1, has been found...
Awards and Honors

Postdoc John Maciejowski wins 2016 Regeneron Prize for Creative Innovation

John Maciejowski, a postdoctoral fellow in Titia de Lange’s Laboratory of Cell Biology and Genetics, has received the 2016 Regeneron Prize for Creative Innovation. The award, given by Regeneron Pharmaceuticals, Inc., recognizes innovative young scientists based on proposals they submit that have ...
Campus News

New faculty member investigates how cells respond to mechanical forces

Whether maneuvering about under their own power, or being pushed and pulled by the surrounding tissue, cells both give and receive mechanical force. The newest addition to Rockefeller University’s faculty, Gregory Alushin, is a biophysicist who investigates how cells use their structural filament...
Campus News

New faculty member investigates how cells respond to mechanical forces

by Wynne Parry, science writer Whether maneuvering about under their own power, or being pushed and pulled by the surrounding tissue, cells both give and receive mechanical force. The newest addition to Rockefeller University’s faculty, Gregory Alushin, is a biophysicist who investigates ...
Science News

Do artificial sweeteners live up to the promise of sweetness without harm? An ongoing clinical study investigates

There was a time when Thomas Huber, a molecular biologist at The Rockefeller University, was drinking about 36 ounces of diet cola a day. More than a year ago, Huber, a research assistant professor in Thomas P. Sakmar’s Laboratory of Chemical Biology and Signal Transduction, became curious about ...
Science News

Researchers uncover how “silent” genetic changes drive cancer

At any given moment, the human genome spells out thousands of genetic words telling our cells which proteins to make. Each word is read by a molecule known as a tRNA. “We’ve long thought of these molecules as little more than middle men participating in the process of translating proteins...
Science News

New method gives scientists a better look at how HIV infects and takes over its host cells

Viruses attack cells and commandeer their machinery in a complex and carefully orchestrated invasion. Scientists have long probed this process for insights into biology and disease, but essential details still remain out of reach. A new approach, developed by a team of researchers led by The Rock...
Campus News

35 labs and counting: How the Robertson Therapeutic Development Fund speeds translational research at Rockefeller

by Alexandra MacWade, assistant editor Developing a new medical product is a complex, high-risk endeavor. Of the thousands of clinically promising concepts scientists formulate each year, only a small fraction move beyond the lab. The Robertson TDF was created to advance work that has gone beyon...
Science News

Scientists find evidence that cancer can arise from changes in the proteins that package DNA

A mutation that affects the proteins that package DNA—without changing the DNA itself—can cause a rare form of cancer, according to new findings in this week’s Science from researchers at Rockefeller University. The mutation is present in histones, the protein scaffolding around which DNA w...
Awards and Honors

C. David Allis receives the 2016 Gruber Genetics Prize

C. David Allis, Joy and Jack Fishman Professor and head of the Laboratory of Chromatin Biology and Epigenetics, has won the 2016 Gruber Genetics Prize. He shares the $500,000 award with Michael Grunstein of the University of California, Los Angeles. The award, given by The Gruber Foundation, reco...
Awards and Honors

Charles Rice wins Belgium’s highest scientific prize

Charles M. Rice, Maurice R. and Corinne P. Greenberg Professor in Virology and head of the Laboratory of Virology and Infectious Disease, has been honored with the 2016 InBev-Baillet Latour Health Prize for his work on the hepatitis C virus. Queen Mathilde of Belgium presented Rice with the prize...

In the News - The New Yorker - Allis

Same but Different: How epigenetics can blur the line between nature and nurture "Allis walked me to his lab, a fluorescent-lit space overlooking the East River, divided by wide, polished-stone benches. A mechanical stirrer, whirring in a corner, clinked on the edge of a glass beaker. 'Two featur...
Science News

Parasites reveal how evolution has molded an ancient nuclear structure

Long before animals evolved from sponges, and before plants evolved out of algae, there was a pivotal event that allowed complex, multicellular organisms to arise: the development of the nucleus in single-celled organisms. Eukaryotes, one of the three main branches of living organisms, are define...
Campus News

Awards, arrivals, and promotions

Congratulations to our latest award winners: Cori Bargmann has won the 2016 Edward M. Scolnick Prize in Neuroscience, an award given by the McGovern Institute for Brain Research at MIT to recognize outstanding advances in the field. She is being honored for her work on the genetic and neural mech...
Science News

A virus common among livestock depends on a microRNA to replicate

In the ongoing arms race between pathogenic viruses and the cells they infect, each side needs every advantage it can get. One way wily viruses can get a leg up is by subverting the microRNAs (miRNAs) of their host. These miRNAs are small stretches of RNA made by host cells to regulate gene expre...
Campus News

Awards, arrivals, and promotions

Congratulations to our latest award winners: Jean-Laurent Casanova has been recognized with the Stanley J. Korsmeyer Award for his work investigating the genetic basis of pediatric infectious diseases. The award is given by the American Society for Clinical Investigation, an honor society of phys...
Science News

Study reveals how herpes virus tricks the immune system

With over half the U.S. population infected, most people are familiar with the pesky cold sore outbreaks caused by the herpes virus. The virus outsmarts the immune system by interfering with the process that normally allows immune cells to recognize and destroy foreign invaders. How exactly the h...
Science News

Experiments explain the events behind molecular ‘bomb’ seen in cancer cells

Since scientists have begun sequencing the genome of cancer cells, they have noticed a curious pattern. In many different types of cancers, there are cells in which a part of a chromosome looks like it has been pulverized, then put back together incorrectly, leading to multiple mutations. For yea...
Science News

New research explores how the fly brain reroutes odor information to produce flexible behavior

Some responses come automatically, like reflexes. Others vary with circumstance and experience. A once-delicious smell can be easily overlooked during a stressful moment or when it calls to mind a bout of food poisoning, for instance. This happens because, within the brain, molecules known as neu...
Science News

Researchers discover new aspect of gene regulation and a possible target for cancer drugs

There are about 20,000 genes in the human genome, but not all are used in all cells at all times. At any given moment, a cell is converting only roughly half its genes into proteins. And of those active genes, about 75 percent are regulated by a process known as “RNA polymerase pausing.” This...
Science News

Study suggests new way to help the immune system fight off sleeping sickness parasite

Some infectious diseases are particularly difficult to treat because of their ability to evade the immune system. One such illness, African sleeping sickness, is caused by the parasite Trypanosoma brucei, transmitted by the tsetse fly, and is fatal if left untreated. The trypanosome parasite is t...
Science News

Mutations in key cancer protein suggest new route to treatments

For years, scientists have struggled to find a way to block a protein known to play an important role in many cancers. The protein, STAT3, acts as a transcription factor—it performs the crucial task of helping convert DNA into the RNA instructions used to make new proteins. But when overly acti...
Science News

DNA strands often “wiggle” as part of genetic repair

Sometimes, the molecules that make up life exhibit strange behavior. For instance, in simple organisms such as yeast, when genetic material becomes damaged, the affected DNA strands increase their motion, waving about inside the cell like a sail unfurled. Over the years, scientists have seen more...

In the News - Newsday - O'Donnell

  Researchers at Brookhaven lab, Stony Brook and Rockefeller universities make new discoveries about double helix copying   "In Manhattan, Michael O'Donnell, who heads Rockefeller's Laboratory of DNA Replication, said the finding will change how students understand DNA replication. 'It's a pa...
Science News

Study reveals the architecture of the molecular machine that copies DNA

DNA replication is essential to all life, yet many basic mechanisms in that process remain unknown to scientists. The structure of the replisome—a block of proteins responsible for unwinding the DNA helix and then creating duplicate helices for cell division—is one such mystery. Now, for the ...
Science News

Discovery of genes involved in inner ear development hints at a way to restore hearing and balance

Loud noise, trauma, infections, plain old aging—many things can destroy hair cells, the delicate sensors of balance and sound within the inner ear. And once these sensors are gone, that’s it; the delicate hair cells don’t grow back in humans, leading to hearing loss and problems with balance. ...
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