A new molecular structure explains how cells hold an alarm-triggering protein captive during cell division, preventing cells from targeting their own DNA.
How do primitive cells “know” where to go during development? Scientists studying the fish equivalent of inner-ear hair cells have shown that biochemical and mechanical cues work together to orchestrate a highly complex arrangement.
Using atomic-resolution technology, scientists have constructed the most detailed view yet of the molecular complex that decides where microtubules form.
Over 130 scientists in 18 labs are conducting research to advance the development of new, urgently needed approaches for the prevention and treatment of COVID-19.
Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.
Scientists have found that many receptors with high potential for drug discovery take a different configuration inside the body than in the test tube. The findings could explain why some promising drugs fail in clinical trials, and potentially open doors to new drug-development approaches.
