Ravetch receives the award for his groundbreaking work analyzing the immune system’s antibody response. He has worked for decades on the Fc fragment of the antibody molecule and its binding partners, known as Fc receptors.
Scientists have developed a new strategy to study the cells that host hidden reserves of dormant HIV, a step that may lead to new treatments that go beyond controlling the infection and instead aim to eradicate the virus entirely.
A chemical inhibitor targeting basal cell carcinoma, originating from Tarun Kapoor’s lab, is graduating from the Tri-Institutional Therapeutics Discovery Institute into Bridge Medicines.
Among other superpowers, stem cells have a knack for fending off viruses like dengue and zika. Scientists have gained new insight into these curious defense strategies—knowledge they say could fuel the development of drugs against a range of diseases.
Thorne is recognized for his deft explanations that have drawn readers into the space-, time-, and mind-bending realm of Einstein’s ideas. The prize, which honors scientists as inspirational authors, will be presented on April 17.
Scientists have discovered a curious way for cells to die. In studying it, they are learning about how remnants of diseased cells are normally chewed up and removed.
The gateway to cellular headquarters has 552 components. A new map that shows how all these pieces fit together could help scientists study numerous diseases.
A new report details three cases of secondary brain tumors in people with fibrolamellar hepatocellular carcinoma. The researchers say imaging tests could improve treatment for patients whose cancer spreads to the brain from the liver.
In discovering how an antibiotic kills the bacteria that cause tuberculosis, scientists open the door to new treatments for the disease—and possibly others, as well.
Scientists have used cryo-electron microscopy to capture the very first snapshots of the large ribosomal subunit—part of the ribosome responsible for forging bonds between amino acids, the building blocks of proteins—coming together.
In mining soil for natural drugs, scientists have discovered a brand-new antibiotic potent against many bacteria. They hope it could be used to treat infections that cannot be stopped with existing drugs.
New research has helped explain what goes wrong in Aicardi-Goutières syndrome, a rare brain disorder. Patients with the disease have genetic abnormalities that may put their cells at risk of accidentally triggering an antiviral response.
Günter Blobel, a Nobel Prize-winning Rockefeller biologist who discovered the mechanisms by which proteins are targeted for delivery to specific locations within cells, died February 18 at 81.
A new study illuminates the biology that guides behavior across different stages of life in worms, and suggests how variations in specific neuromodulators in the developing nervous system may lead to occasional variations.
After figuring out the functions of two proteins involved in the rare genetic condition ICF, scientists pieced together the molecular process that is altered in the disease.
Our ability to hear relies on tiny bundles of hair-like sensors inside the inner ear. Scientists have identified a key component of the machinery that makes these bundles grow in an orderly fashion.
Virtually all aspects of life and disease depend of brief exchanges between cells. A new technique to study cell-to-cell contacts lets interacting cells “smear” one another with the biological equivalent of lipstick.
The symptoms of Huntington’s typically appear in middle age, but the disease may in fact originate much earlier. New research shows that a patient’s neural abnormalities may arise already during embryonic development—suggesting that treating the disease early may be beneficial.
A new treatment may help cancer patients who don't respond to traditional immunotherapy. Findings from the first-ever clinical trial reveal that it is effective in activating immune cells that kill cancer cells.
New research shows that subtle differences between bacterial strains may cause dramatic differences in outcome between people infected with the same microbe.
As inaugural Sanders Director Dr. Michael Foley is set to depart the Tri-Institutional Therapeutics Discovery Institute later this year, two projects from a portfolio of 57 that the Tri-I TDI has supported are now ready for the next phase of therapeutic development—a phase intended to lead to inv...
With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.
Scientists found that immune cells called intraepithelial lymphocytes act as a surveillance force at the intestine, helping to generate an appropriate immune response to both friendly bacteria and dangerous pathogens.
Scientists studying the cell’s DNA-copying machinery have discovered a molecular mechanism that helps reactivate it should it stop prematurely. Its function may prevent genetic errors like those that cause cancer.
Scientists have discovered a group of brain cells that may play a role in keeping smokers addicted to nicotine. Their work could ultimately lead to new drugs to help people conquer their tobacco dependence.
Ruta, who explores how brains produce such flexible responses to fixed stimuli, has been promoted to Gabrielle H. Reem and Herbert J. Kayden associate professor.
Kronauer has been promoted to associate professor. He has dedicated his laboratory to investigating the molecular basis underlying complex social behavior among insects.
A protein transferred from male to female mosquitoes during sex influences female mating behavior—a phenomenon that could be exploited to limit the spread of mosquito-borne illnesses like Zika and dengue.
Nussenzweig was honored at a ceremony today at the Institut Pasteur in Paris.The award recognizes investigators for past or ongoing work demonstrating real scientific progress in the life sciences.
Young was honored for his discoveries of molecular mechanisms controlling the circadian rhythm. He accepted the Nobel medal and diploma from King Carl XVI Gustaf of Sweden.
Researchers have found that the cells directing the very first steps of brain formation are not other neurons, as scientists have long assumed. They've also uncovered previously hidden molecular pathways that attract neurons into the brain.
Hatten is awarded for her significant contributions to neuroscience. She studies the mechanisms of neuronal differentiation and migration during the early stages of embryonic development.
Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They’ve used it to clarify what drives these tumors at the molecular level, and discover new drug concepts.
Scientists have discovered a peculiarity in the genetic code of HIV that might explain how this and other viruses evolved ways to dodge our immune system. The findings could make it possible to develop safer vaccines.
Scientists have identified a protein that many viruses require to spread within a host—a discovery that could lead to fighting diseases as varied as parainfluenza, West Nile, and Zika with a single drug. This finding could also lead to the development of treatments for emerging viruses.
Scientists found that inhibiting a regulatory protein alters the intricate signaling chemistry that is responsible for many of the disease’s symptoms. The findings provide a path to possible therapeutics for disorders associated with Fragile X.
Scientists have found that stem cells in the skin remember an injury, helping them close recurring wounds faster. The discovery could advance research and treatment of psoriasis and other inflammatory diseases.
Bargmann is honored for her research exploring how genes and the environment interact to generate a variety of behaviors, and how behavioral decisions are modified by context and experience.
Cohen was an emeritus faculty member at The Rockefeller University and leader in statistical physics and nonequilibrium statistical mechanics. He died September 24 at the age of 94.
One of the most prestigious funding programs in the world, the MacArthur fellows program awards grants to exceptionally creative individuals as an investment in their potential.
Scientists have found unexpected differences in how male and female mice respond to stress. Their findings are raising big questions about sex discrepancies in the brain and their impact on neuropsychiatric disease.
Stubbe is being recognized for illuminating the processes that drive DNA replication and repair. Her research has led to the development of several cancer therapies.
Rockefeller University biologist Michael W. Young, who studies the biological clocks that regulate sleep, metabolism, and response to disease, is this year’s recipient of the Nobel Prize in Physiology or Medicine.
To keep up with evasive flu viruses, new vaccines must be developed each year. Scientists are devising a strategy to better prevent the disease without annual shots.
Zabriskie was a leader in the investigation of streptococcal infections and their long-term side effects, including rheumatic fever and autoimmune disorders. He died August 17 at the age of 88.
Scientists developed a method to genetically engineer gut bacteria to produce molecules that have the potential to treat certain disorders by altering human metabolism.
Scientists have located two areas in the brain that help us recognize familiar faces. The discovery will help them delve deeper into the relationship between face recognition, memory, and social knowledge.
Scientists disrupted a gene essential for sensing pheromones, resulting in severe deficiencies in the ants’ social behaviors and their ability to survive within a colony.
Within the oldest part of the brain, scientists have found cells in charge of controlling appetite and eating. The discovery could revitalize efforts to develop drugs for obesity that make us less hungry.
Neuroscientists have taken a major step toward answering longstanding questions about how Prozac and similar drugs act in the brain. Their findings could lead to better antidepressants that don't take weeks to kick in.
