Skip to main content
!
Phase III+: The University is open for expanded research operations; only authorized personnel will be admitted on campus. More info here.
!
Phase III+: The University is open for expanded research operations; only authorized personnel will be admitted on campus. More info here.
!
Phase III+: The University is open for expanded research operations; only authorized personnel will be admitted on campus. More info here.

A summer program that gives undergraduates the tools to ask big scientific questions

Madeleine Delbeau, who spent 10 weeks in the lab of Seth A. Darst, improves a method for cryo-electron microscopy.

Zoran Jankovic, a member of the Nussenzweig lab for nearly two decades, dies at 60

Zoran Jankovic, known for his generous spirit and unassuming manner, worked in the Nussenzweig lab for nearly 20 years.

>

Study sheds new light on how epigenetic events might spur disease

Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.

The pathway to Parkinson’s takes a surprising twist

A new study finds that neurons affected in Parkinson’s disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wreaks havoc in the brain, as well as ideas for new treatments.

Lymphatic system found to play key role in hair regeneration

To grow new hair, stem cells throughout the skin must work in sync. Researchers have discovered the molecular communication tool, part of the lymphatic system, that the cells use to synchronize their activities.  

The Abby Dining Room turns a page

Earlier this month, the Abby reopened with table service, libations, and new menus.

Xiaowei Zhuang will receive the 2019 Pearl Meister Greengard Prize

Zhuang, who pioneered the development of super-resolution and genome-scale imaging techniques, will be given the prize during a ceremony on the Rockefeller campus on November 19.

Study pinpoints rare genetic change that may boost risk of HPV-related illness

The human papilloma virus is usually kept in check by the immune system, but scientists identified a genetic variant that makes some infected children prone to developing warts in the throat.

C. David Allis elected to the National Academy of Medicine

Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.

Biologist and ant paparazzo Daniel Kronauer recognized in Wildlife Photographer of the Year competition

An expert on ant biology, Kronauer found himself in the right place at the right time to capture a cathedral-shaped bivouac, or ants’ nest, in Costa Rica. The photo is now part of an international exhibit by the prestigious Wildlife Photographer of the Year competition.

Research on cell division provides new clues to how a common cancer treatment works

In studying cell division, scientists happened upon a new way of understanding how a chemotherapy compound works. The findings could make it possible to predict which patients are most likely to benefit from the drug.

Shapeshifting receptors may explain mysterious drug failures

Scientists have found that many receptors with high potential for drug discovery take a different configuration inside the body than in the test tube. The findings could explain why some promising drugs fail in clinical trials, and potentially open doors to new drug-development approaches.

Tips for a greener lab

Even the most routine scientific experiment may come with a hefty environmental footprint. Here are several best practices to reduce waste, save energy, and cultivate more planet-friendly lab habits.

Vanessa Ruta named a 2019 MacArthur Fellow

Ruta, who investigates how the brain is modified by experience, has received a MacArthur Fellowship, an award intended to encourage people of outstanding talent to pursue their own creative, intellectual, and professional inclinations.

>

Study gives clues to the origin of Huntington’s disease, and a new way to find drugs

Using a new technique to study brain development, scientists were able to trace the causes of Huntington's back to early developmental stages when the brain has only just begun to form.

Jeffrey M. Friedman to receive 2020 Breakthrough Prize in Life Sciences

Friedman's discovery of the hormone leptin has transformed our understanding of obesity.

Recent donations establish centers for computational science and for metabolism, and renew resources for faculty recruitment

The university’s Campaign for Transforming Biomedicine—which raised $1.17 billion over eight years—closed this summer with a bang: three significant capstone gifts, made in the campaign’s final months, to directly support Rockefeller science.

Becoming a Scientist: Priya Rajasethupathy 

Memories are inherently shifty. A neuroscientist with a new lab of her own, Rajasethupathy likens the brain’s memory function to Wikipedia—always evolving, occasionally unreliable.

From the tiny testes of flies, new insight into how genes arise

A common birthplace of new genes, the male testes are a hotspot for biological innovation. Within these organs, scientists have found a trove of virgin genetic sequences—and a better understanding of how evolution moves forward.

Findings shed new light on why Zika causes birth defects in some pregnancies

Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.

With tiny technological tweezers, researchers uncover new aspects of cell division

Cell division is critical to creating and sustaining life. It’s also incredibly difficult to study. Now, advanced technology is enabling researchers to take their understanding of this process to the next level.

Interview: Ali H. Brivanlou 

With science constantly advancing, ethical boundaries need regular recalibration. It’s a task scientists cannot do alone, says Brivanlou; all of society needs to engage.

Exploring genetic “dark matter,” researchers gain new insights into autism and stroke

For the brain to function smoothly, its cells must carefully regulate which proteins are produced and when. By studying gene regulation, researchers are now shedding light on complex brain conditions like autism and stroke.

Fruit flies find their way by setting navigational goals

Navigating fruit flies do not have the luxury of GPS, but they do have a kind of neural compass. In a new study, researchers found that the animals decide which way to turn by comparing this internal compass needle to a fixed goal.

David Rockefeller Fellowships awarded to graduate students Stephanie Marcus and Zachary Mirman

The fellowships recognize their research and leadership within the student community.

Sebastian Klinge promoted to associate professor

Klinge studies the mechanisms by which ribosomes—the intricate machines that manufacture every cell’s proteins—are assembled.

Hinge-like protein may open new doors in cystic fibrosis treatment

Drugs known as potentiators alleviate some symptoms of cystic fibrosis. Researchers recently figured out how these compounds work—a finding that may lead to better drugs that patients can more easily afford.

Celebrating and remembering Mitchell Feigenbaum, physicist who pioneered chaos theory

A mathematical physicist, Feigenbaum's groundbreaking work on deterministic chaos influenced fields ranging from cardiology to cartography. He died on June 30, at age 74.

Three-dimensional model illuminates key aspects of early development

Researchers have created a new 3D model of human embryonic tissue that promises to shed light on critical components of development—including processes that go awry during pregnancy complications.

New research raises prospect of better anti-obesity drugs

Scientists have found a group of brain cells that influence body mass in two ways, by controlling how much we eat as well as how much energy we burn. The findings could lead to new drugs to help people shed weight.

Learning from experience is all in the timing

Animals learn the hard way which sights, sounds, and smells are relevant to survival. New research in flies shows that the timing of these cues plays an important role in how mental associations arise, and elucidates brain pathways involved in this process.

The future of TB is TBD 

Deadly and elusive, M. tuberculosis has ravaged the world for centuries. Armed with new technologies to study the pathogen, scientists may finally be poised to intervene.

The River Campus is open for business

After four years of construction, the Stavros Niarchos Foundation–David Rockefeller River Campus has opened its doors to the community, with several labs already installed in its new research building.

>

New molecular diagnostics test could help guide lupus treatments

A tool that detects glitches in gene expression could help doctors tailor treatments for lupus-related kidney damage.

Rockefeller tops global ranking of research excellence

An extensive international ranking of research institutions by U-Multirank gave Rockefeller top scores in several categories related to scientific impact and knowledge transfer.

>

New research shows that mosquitoes sense repellent through their legs

Scientists made the surprising discovery that the insects’ displeasure for touching DEET, the active ingredient in many repellents, helps prevent bites.

Small brains, big decisions 

Life is full of binary choices, even for small animals like fruit flies. With new technologies, scientists can now dissect the mechanisms of decision making in the simplest of brains, at the levels of individual molecules, cells, and networks.

To curb infection, bacteria direct their defenses against themselves

To fight off invading viruses, bacteria have evolved a slew of creative defense tactics. New research shows that in some cases, microbes go to great lengths to keep an infection from spreading, even destroying bits of their own genetic material.

New compounds could be used to treat autoimmune disorders

In autoimmune disorders, the body’s defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions.

New study reveals gut segments organized by function, and opportunities for better drug design

New findings provide insights about how the intestine maximizes nutrient uptake, while at the same time protecting the body from potentially dangerous microbes.

An accreditation renewal, and the campus-wide endeavor to ensure continued safeguarding of research participants

Rockefeller's reaccreditation from the Association for the Accreditation of Human Research Protection Programs marks the end of an extensive application process. The AAHRPP sets the gold standard in safeguarding volunteers participating in clinical research.

A new sculpture, donated by Torsten N. Wiesel, is perched in front of Flexner Hall

The cast-iron parrot is an architectural ornament from the late 19th or early 20th century.

Cellular rivalry promotes healthy skin development

Scientists have discovered a curious phenomenon taking place in mouse skin: cells compete with one another for the chance to develop into mature tissue. The findings indicate that this antagonism is key to creating healthy skin.

>

Researchers find genetic link to tuberculosis

Rockefeller scientists have identified a genetic condition that makes people prone to developing tuberculosis. In a British population, they found that the condition underlies one percent of cases of the disease—a finding that may ultimately lead to new treatment options.

>

Study explores genetic differences among people’s gut microbes, and their health consequences

Scientists have found that small genetic differences can cause the same gut microbe to behave differently in different people, and affect the overall health of their human hosts.

Research on repetitive worm behavior may have implications for understanding human disease

Studying microscopic worms, Rockefeller scientists have identified a brain circuit that drives repetitive behavior—providing potential clues for understanding some human psychiatric conditions.

Jue Chen and Luciano Marraffini elected to National Academy of Sciences

Election to the National Academy of Sciences is one of the most prestigious honors a scientist can receive; including Chen and Marraffini, the number of current Rockefeller scientists who are members of the elite organization stands at 38, or nearly half the faculty.

Drugs from dirt 

Therapeutics has gone underground. From one bag of soil, chemists can now procure millions of microbial molecules. Any one could be tomorrow’s lifesaving medicine.

Study pinpoints what causes relapse after cancer immunotherapy

In many cancer patients who have been treated with immunotherapy, the tumor comes back. New research identifies the cells responsible for thwarting the treatment and offers new insights into how they do it.

>

Gene-editing technique opens door for HIV vaccine

Researchers successfully modified immune cells to produce antibodies that fight HIV. This strategy could eventually be used to develop a vaccine against the virus, among other conditions.

Rockefeller creativity on display at the 21st annual employee art show

This year’s show featured portraiture, travel photography, collage, and other mediums.

Celebrating and remembering Paul Greengard, a pioneering neuroscientist and Nobel laureate

Greengard revolutionized our understanding of how brain cells communicate with each other and contributed to major advances in the treatment of a wide range of neurological and psychiatric diseases. He died April 13 at the age of 93.

New microscopy technique peers deep into the brain

Using new imaging technology, researchers can now record the activity of large populations of brain cells with unprecedented speed, and at new depths.

New hope for treating a childhood brain cancer

Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors.

New approach to treating gastrointestinal disease patches up leaky intestines

Researchers have discovered a new compound that helps fortify the intestine's inner lining, which becomes porous in inflammatory bowel diseases.  

Scientists find brain mechanism that naturally combats overeating

Studying a brain region involved in memory, researchers discovered a set of neurons that help mice control their appetite.

>

New tool allows scientists to catch elusive protein in action

Scientists still have a lot to learn about the processes that trigger cell division, partly because they happen so quickly. A new chemical probe will make it possible to capture the workings of one of the key players.

Physician-writer Siddhartha Mukherjee will be awarded the 2019 Lewis Thomas Prize

The author of The Emperor of all Maladies, a best-selling book about cancer, will be presented with Rockefeller’s science writing award at a free, public ceremony on Rockefeller's campus next month.

>

Researchers discover a common link among diverse cancer types

Some cancers have been traced to changes in histones, proteins responsible for packaging DNA and regulating genes. Now, research from Rockefeller scientists shows that, among tumors, mutations to these proteins are a lot more common than previously suspected.

The face-recognition puzzle 

For the brain, seeing a face is very different from seeing a teacup. In studying a mysterious ailment, face blindness, scientists are getting a rare glimpse into the biology of the mind.