Drugs known as potentiators alleviate some symptoms of cystic fibrosis. Researchers recently figured out how these compounds work—a finding that may lead to better drugs that patients can more easily afford.
Scientists have found a group of brain cells that influence body mass in two ways, by controlling how much we eat as well as how much energy we burn. The findings could lead to new drugs to help people shed weight.
Animals learn the hard way which sights, sounds, and smells are relevant to survival. New research in flies shows that the timing of these cues plays an important role in how mental associations arise, and elucidates brain pathways involved in this process.
After four years of construction, the Stavros Niarchos Foundation–David Rockefeller River Campus has opened its doors to the community, with several labs already installed in its new research building.
Life is full of binary choices, even for small animals like fruit flies. With new technologies, scientists can now dissect the mechanisms of decision making in the simplest of brains, at the levels of individual molecules, cells, and networks.
To fight off invading viruses, bacteria have evolved a slew of creative defense tactics. New research shows that in some cases, microbes go to great lengths to keep an infection from spreading, even destroying bits of their own genetic material.
In autoimmune disorders, the body’s defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions.
Rockefeller's reaccreditation from the Association for the Accreditation of Human Research Protection Programs marks the end of an extensive application process. The AAHRPP sets the gold standard in safeguarding volunteers participating in clinical research.
Scientists have discovered a curious phenomenon taking place in mouse skin: cells compete with one another for the chance to develop into mature tissue. The findings indicate that this antagonism is key to creating healthy skin.
Rockefeller scientists have identified a genetic condition that makes people prone to developing tuberculosis. In a British population, they found that the condition underlies one percent of cases of the disease—a finding that may ultimately lead to new treatment options.
Election to the National Academy of Sciences is one of the most prestigious honors a scientist can receive; including Chen and Marraffini, the number of current Rockefeller scientists who are members of the elite organization stands at 38, or nearly half the faculty.
In many cancer patients who have been treated with immunotherapy, the tumor comes back. New research identifies the cells responsible for thwarting the treatment and offers new insights into how they do it.
Greengard revolutionized our understanding of how brain cells communicate with each other and contributed to major advances in the treatment of a wide range of neurological and psychiatric diseases. He died April 13 at the age of 93.
Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors.
Scientists still have a lot to learn about the processes that trigger cell division, partly because they happen so quickly. A new chemical probe will make it possible to capture the workings of one of the key players.
Some cancers have been traced to changes in histones, proteins responsible for packaging DNA and regulating genes. Now, research from Rockefeller scientists shows that, among tumors, mutations to these proteins are a lot more common than previously suspected.
Scientists discovered a protein that plays a crucial role in regulating fatty acids, the molecules that make up body fat. This research could lead to new options for treating people with diseases associated with fatty acid buildup.
New research on leptin, a hormone that regulates appetite, reveals a previously unknown mechanism that may be responsible for at least 10 percent of obesity cases. The findings could help identify individuals with treatable forms of the condition.
When looking for food, the roundworm C. elegans searches the same area for up to 20 minutes before trying its luck at more distant locales. New research on the worm’s brain explains how this behavior arises at the level of molecules and cells.
Researchers have identified a rare type of cancer cell that cannot make cholesterol, a key nutrient. By targeting this deficiency, scientists may be able to develop new strategies for treating the disease.
Scientists have learned new tricks that could be useful in preventing mosquito-borne illnesses such as Zika and yellow fever. A new study shows that some appetite-reducing drugs can curtail the insects’ impulse to feed on warm-blooded hosts.
Increasingly, bacteria do not succumb to antibiotics. Rockefeller researchers have developed a new class of antimicrobial drug, lysin, with one compound showing promising results in a clinical trial—suggesting that an alternative to antibiotics may be on the horizon.
Medical science is holding its breath. For decades, the most it could do for people with HIV was to prevent them from dying of AIDS. Now, new therapies are raising hopes for something more: a world in which the virus will no longer cause suffering or fear.
Bacteria use a multifaceted immune response to get rid of invading DNA. In a new study, researchers identify an enzyme that can destroy foreign genetic material capable of evading a microbe’s first line of defense.
Over 230 attendees from across the country came to campus to learn about a range of topics, such as the federal budget, international science diplomacy, science advocacy, science communication, and careers in science policy.
DNA’s two strands must be separated before its code can be read, or transcribed. By studying the structure of the enzyme RNA polymerase, researchers have elucidated how DNA unwinds and becomes legible.
Attallah Kappas, professor emeritus at The Rockefeller University and physician-in-chief emeritus at The Rockefeller University Hospital, died December 18, 2018 at the age of 92. Kappas was a leading authority in diseases related to liver function and metabolism and in the development of diagnost...
Scientists discovered a genetic variant that greatly increases a person’s likelihood of developing tuberculosis. Their research elucidates how this mutation affects the immune system, and points to a possible treatment for people with the disease.
President Rick Lifton has established a committee to guide the strategic planning process. It will be informed by presentations from administrative departments as well as input from the community at large.