Linker histone H1 appears capable of distinguishing between single-stranded and double-stranded DNA, suggesting that its role in maintaining our genomes extends far beyond that of keeping chromosomes compact.
The compound attacks MRSA, C. diff, and several other deadly pathogens. Its discovery demonstrates the power of combining computational biology, genetic sequencing, and synthetic chemistry to study bacterial evolution.
A new study reveals how the drug fidaxomicin selectively targets a dangerous pathogen without causing harm to beneficial bacteria. The findings could inform the development of new narrow-spectrum antibiotics for treating other types of infection.
Increasingly, hospitalized patients contract infections that evade current antibiotics including colistin, long used as a last treatment option. The discovery of a new colistin variant might make it possible to outmaneuver these pathogens.
A new study finds that proteins known as linker histones control the complex coiling process that determines whether DNA will wind into long and thin chromosomes, made up of many small loops, or short and thick chromosomes with fewer large loops.