One of the most common drug resistance mutations in tuberculosis creates subtle metabolic weaknesses that could be exploited with future combination therapies.
RNA polymerase, the enzyme that synthesizes RNA from DNA during transcription, has been captured mid-reaction for the first time. The findings provide a universal blueprint for gene expression.
The two scientists are the 35th and 36th members of Rockefeller's current faculty to be honored with membership in the prestigious academy founded by Abraham Lincoln.
Long thought to serve as cellular scaffolding, microtubules also reshape the proteins that bind to them—guiding enzyme activity to prevent genetic errors linked to cancer.
A new cell-free genomics framework isolates the primary impacts of transcription factors and establishes tuberculosis as a model for understanding how genes are regulated.
Researchers discovered that a crucial first step in the signaling system operates differently than previously thought, an insight that could lead to the next generation of treatments.
Researchers found that pairing the antibiotic rifampicin with a second compound turned multidrug resistance into a weakness—providing proof of concept for using basic science to design life-saving dual-drug strategies.
