One of the most common drug resistance mutations in tuberculosis creates subtle metabolic weaknesses that could be exploited with future combination therapies.
RNA polymerase, the enzyme that synthesizes RNA from DNA during transcription, has been captured mid-reaction for the first time. The findings provide a universal blueprint for gene expression.
The two scientists are the 35th and 36th members of Rockefeller's current faculty to be honored with membership in the prestigious academy founded by Abraham Lincoln.
Long thought to serve as cellular scaffolding, microtubules also reshape the proteins that bind to them—guiding enzyme activity to prevent genetic errors linked to cancer.
A new cell-free genomics framework isolates the primary impacts of transcription factors and establishes tuberculosis as a model for understanding how genes are regulated.
Researchers discovered that a crucial first step in the signaling system operates differently than previously thought, an insight that could lead to the next generation of treatments.
Researchers found that pairing the antibiotic rifampicin with a second compound turned multidrug resistance into a weakness—providing proof of concept for using basic science to design life-saving dual-drug strategies.
Their newest technique has already uncovered hundreds of hidden bacterial genomes and two promising antibiotics. Now, the same approach could unlock an entire microbial universe—reshaping drug discovery and our understanding of how bacteria shape our environment.
Newly identified compounds appear effective against drug-resistant bacteria. The technique used to reveal them could uncover many more antibiotics, as well as help illuminate a previously hidden microbial world.
New research demonstrates that a previously published structure and mechanism for RNA capping at work in coronaviruses is incorrect, with potentially sweeping implications for the quest to develop drugs targeting these pathogens.
Mojsov is recognized for her discovery of the peptide hormone GLP-1, research that led to a new class of safe and highly effective drugs for type 2 diabetes as well as the treatment of obesity.
A collaboration between Rockefeller, MSK, and Weill Cornell answers a longstanding
mystery about the basic biology of the hepatitis B virus, while also proposing a novel therapy.
Male fruit flies don’t just sing to their mates; they also use sound-cancelling wing-flicks to jockey with rivals. This new understanding of how male flies compete for female partners could shed light on how the brain balances cooperation and competition.
Researchers discovered a vulnerability in viral enzymes that could lead to novel treatments for diseases as diverse as COVID and Ebola, while also minimizing side effects and reducing the odds of drug resistance.
Thomas Tuschl has devoted his career to making discoveries that bridge the gap between bench and business—and have resulted in entirely new classes of drugs.
