Proteomics Resource Center
COVID-19 Update: As of July 6 The University has entered Phase III..
- PRC will continue to accept requests for all services. Expect longer turn-around for some specialized requests.
- The PRC continues to use 0-contact sample drop-off. DO NOT prepare samples and DO NOT come to the PRC before carefully reading the protocol for sample drop-off .
- User instruments (GCMS, LC based Fractionation and Typhoon scanner) are available for users proficient in operating the needed instrument. Instruments are available 24/7. Scheduling is currently only available by contacting firstname.lastname@example.org.
The Proteomics Resource Center (PRC) at The Rockefeller University offers analysis of biomolecules and peptide synthesis for The Rockefeller University community on a subsidized, cost-recovery basis. The Center is also available to other not-for-profit institutions. The Center is located in the south eastern part of The Rockefeller University campus in The Rockefeller Research Building: RRB157. The Center is guided by and reports to a Scientific Advisory Committee (SAC) on a regularly basis.
The PRC team members are analytical chemists with expertise in proteomics, metabolomics and peptide chemistry. The corner stone of the Center is liquid chromatography (LC) and mass spectrometry (MS) which we apply to proteomics, metabolomics, lipid and small molecule analysis – see examples of projects analyzed by the Center.
The Center is equipped with nano-flow as well as higher flow LC. The majority of our instruments are of the Orbitrap type which offer high mass accuracy and high resolution. A triple quadrupole mass spectrometer is also available. The Center is equipped with, and has expertise in using, a wide array of software for data analysis. A full list of hardware and software are available here. Selected instruments housed in the Center are available for walk-up use.
Peptide synthesis is also offered by the Center. The peptide synthesis laboratory synthesizes unique custom peptides with or without a variety of standard PTM additions, dyes and/or stable isotope labeled residues, as well as peptide sets for epitope mapping projects or screening.
The goal of the Proteomics Resource Center is to extend the limits of sensitivity and broaden the range of tools provided to investigators by implementing and developing novel and useful analytical techniques. To achieve the above we operate in a boutique style, encouraging the PRC scientists and users to collaborate to create a tailored approach to fit the many unique questions that can be answered using our tools and expertise. On a yearly basis, the Center is working with approximately 200 individual users and handles 500+ sample requests making the Center the to-go-to place to discuss proteomic concepts, experiments and data analysis
A short text describing the Proteomics Resource Center for e.g. grant applications is available here.