Proteomics Resource Center
COVID-19 Update: The Proteomics Resource Center is curtailing activities beginning Monday, March 16, with the goal of full shutdown by Wednesday, March 18. Following that date, the Center will not be staffed to provide any services. Also, user accessible equipment will be shut down and not be accessible even to qualified independent users. PRC team members will still be available by email – please see contact page for appropriate emails.
The Proteomics Resource Center (PRC) at The Rockefeller University offers analysis of biomolecules and peptide synthesis for The Rockefeller University community on a subsidized, cost-recovery basis. The Center is also available to other not-for-profit institutions. The Center is located in the south eastern part of The Rockefeller University campus in The Rockefeller Research Building: RRB157. The Center is guided by and reports to a Scientific Advisory Committee (SAC) on a regularly basis.
The PRC team members are analytical chemists with expertise in proteomics, metabolomics and peptide chemistry. The corner stone of the Center is liquid chromatography (LC) and mass spectrometry (MS) which we apply to proteomics, metabolomics, lipid and small molecule analysis – see examples of projects analyzed by the Center.
The Center is equipped with nano-flow as well as higher flow LC. The majority of our instruments are of the Orbitrap type which offer high mass accuracy and high resolution. A triple quadrupole mass spectrometer is also available. The Center is equipped with, and has expertise in using, a wide array of software for data analysis. A full list of hardware and software are available here. Selected instruments housed in the Center are available for walk-up use.
Peptide synthesis is also offered by the Center. The peptide synthesis laboratory synthesizes single peptides with or without modifications and/or stable isotope labeled residues, as well as peptides for arrays.
The goal of the Proteomics Resource Center is to extend the limits of sensitivity and broaden the range of tools provided to investigators by implementing and developing analytical techniques. To achieve the above the we operated in a boutique style, encouraging the PRC scientists and users to team up to create a tailored approach to fit the many unique questions that can be answered using our tools and expertise. On a yearly basis, the Center is working with approximately 200 individual users and handles 500+ sample requests making the Center the to-go-to place when there is a need to discuss ideas and experiments.
A short text describing the Proteomics Resource Center for e.g. grant applications is available here.