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Hundreds of new drug targets to combat tuberculosis

The study highlights genes that, when silenced, render Mycobacterium tuberculosis vulnerable to antibiotics, and identifies existing drugs that may be effective against one prominent strain.

One protein's surprising partnership with single-stranded DNA

Linker histone H1 appears capable of distinguishing between single-stranded and double-stranded DNA, suggesting that its role in maintaining our genomes extends far beyond that of keeping chromosomes compact.

A synthetic antibiotic may help turn the tide against drug-resistant bacteria

The compound attacks MRSA, C. diff, and several other deadly pathogens. Its discovery demonstrates the power of combining computational biology, genetic sequencing, and synthetic chemistry to study bacterial evolution.

The genetic underpinnings of severe staph infections

A mutated gene may explain why some Staphylococcus aureus infections turn lethal, a finding with significant implications for people living with 5p- syndrome.

Titia de Lange elected to the Royal Society

She receives the honor for elucidating mechanisms of telomere protection and genome maintenance.

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Antibody therapy controls HIV for months in new clinical trial

Unlike conventional antiretroviral drugs, treatment with broadly neutralizing antibodies does not rely on vigilant daily dosing and could potentially reduce the body’s reservoir of latent viruses.

Shixin Liu, expert in single-molecule studies of biological machines, is promoted to associate professor

Liu’s pioneering research on nano-scale molecular events is furthering our knowledge of how DNA replication and gene expression are regulated.

Kivanç Birsoy, expert on cancer cell metabolism, is promoted to associate professor 

Birsoy's groundbreaking research has highlighted key nutrients that cancer cells need to survive, while shedding light on debilitating mitochondrial diseases and rare genetic disorders.

Richard P. Lifton to be honored with 2023 Kober Medal

Lifton, who pioneered the use of genomics to identify the basis for diseases, is recognized for a lifetime of contributions in science and mentorship.

How a narrow-spectrum antibiotic takes aim at C. diff

A new study reveals how the drug fidaxomicin selectively targets a dangerous pathogen without causing harm to beneficial bacteria. The findings could inform the development of new narrow-spectrum antibiotics for treating other types of infection.

The human genome is, at long last, complete

Even after 20 years of upgrades, eight percent of the human genome was still left unsequenced and unstudied. Until now.

The Board of Trustees has eight new members

With a breadth and depth of experience across academia, the pharmaceutical industry, technology, healthcare, and the financial sector, this latest cohort of trustees brings new skill sets and perspectives to the community.

How bacteria "self-vaccinate" against viral invaders

In studying how bacteria respond to viral infection, scientists are learning that their defense strategies cooperate in ways reminiscent of the elaborate immune systems of animals.

Social psychologist Jennifer L. Eberhardt to be awarded the 2022 Lewis Thomas Prize

The author of Biased: Uncovering the Hidden Prejudice That Shapes What We See, Think, and Do will be presented with Rockefeller’s prestigious science writing award on April 7.

Rockefeller president Richard P. Lifton releases statement on Russian invasion of Ukraine

In response to the Russian invasion of Ukraine on February 24, 2022, Rockefeller University President Richard P. Lifton today released the following statement: The Rockefeller University is a vibrant, international community. Our scientists, students, and staff come from all over the world, inclu...

Rockefeller Nobelists co-sign open letter condemning Ukraine invasion

Read the letter signed by 168 Nobel Prize winners, including five Rockefeller scientists.

Stavros Niarchos Foundation–David Rockefeller River Campus receives LEED gold certification

One of only a handful of laboratory settings in New York City to receive the designation, the new river campus is recognized for its numerous energy efficient features.

Scientists discover new mechanism involved in learning and memory

FMRP, a protein whose loss causes intellectual disability, may regulate a neuron's synaptic response by establishing a feedback loop between the cell's nucleus and its faraway dendrites.

Insights into a cystic fibrosis treatment may herald a novel class of drugs 

Protein folding diseases, from Alzheimer's to Gaucher's, may one day be treated by a unique class of protein corrector molecules that are already helping manage cystic fibrosis.  

IT upgrades bolster university’s defenses against cybercriminals

Rockefeller’s Information Security team has implemented one of the most substantial upgrades in its history. As backend protections are strengthened, community members also have a critical role to play.

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New comprehensive map of the portal to the cell’s nucleus

The findings, which may have implications for a wide range of human diseases, suggest that nuclear pore complexes vary in structure and function even within a single nucleus.

A novel compound might defeat multidrug-resistant bacteria common in hospitals

Increasingly, hospitalized patients contract infections that evade current antibiotics including colistin, long used as a last treatment option. The discovery of a new colistin variant might make it possible to outmaneuver these pathogens.

Ashton Murray is named chief diversity officer

Murray will become Rockefeller’s inaugural chief diversity officer and vice president for diversity, equity, and inclusion on January 10.

Waddling water bears, grandmother neurons, and other memorable science stories of 2021

This year's scientific endeavors included multiple attacks on SARS-CoV-2—and a lot more. Here are the most memorable science stories to come out of Rockefeller labs in 2021, from the benefits of brown fat to the pitfalls of modern IVF screening techniques.

Sid Strickland will step down from role of dean of graduate and postdoctoral studies

After 21 years, Sidney Strickland will exit his administrative role, returning full time to his laboratory research at Rockefeller.

New evidence that boosters may be crucial in protecting against Omicron

Researchers found that the antibodies present in people who have had COVID or taken two doses of mRNA vaccine are inadequate against Omicron. But their protective ability increases significantly after a booster dose.

How a fly's brain calculates its position in space

New research reveals how neurons in a fly's brain signal the direction in which the body is traveling. The cells appear to literally perform vector math in order to act as a biological compass.

Llama antibodies could help fight SARS-CoV-2 variants

Scientists have identified hundreds of llama-derived antibodies that potentially could be developed into a COVID treatment. They hope such a drug would be potent against different variants of the coronavirus, including Omicron.

How cells feel their way 

A single cell has no nerves, yet it can feel and respond to mechanical forces such as pressure. Armed with new technologies, scientists are making headway in understanding how this sensory system operates.

Stem cell memories may drive wound repair—and chronic disease

Epidermal stem cells that hail from the hair follicle retain memories of their journey to the skin's surface. Those memories are a boon for wound repair, but may also contribute to chronic diseases and cancer.