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Noninfectious versions of SARS-CoV-2 provide powerful research tools
The new experimental system will facilitate efforts to study different coronavirus variants and develop new drugs for
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    • A mission to end metastasis 
    Not all cancer cells are killers. One lab is focusing its energy on only those that enable tumors to spread—and it may have found their kryptonite.
    Small molecule may prevent metastasis in colorectal cancer

    The compound works by hindering a key pathway that cancer cells rely upon to hoard energy, and is already undergoing clinical trials.

    Study detects origins of Huntington's disease in two-week-old human embryos
    The findings shed new light on the root causes of this disease, which leads to the degeneration of neurons in midlife.
    Seth A. Darst honored with Gregori Aminoff Prize
    Darst receives the honor for pioneering research on RNA polymerase, the molecular machine that transcribes RNA from DNA. His work is leading to new knowledge about the transcription process, as well as to insights enabling development of urgent antibiotic and antiviral treatments.
    Katalin Karikó named the 2022 recipient of the Pearl Meister Greengard Prize
    Katalin Karikó discovered how to keep synthetic RNA from activating the innate immune system, paving the way for RNA vaccines including two for SARS-CoV-2.
    Novel method for trapping HIV inside its host may give rise to new antivirals
    Human cells can be coaxed into preventing certain enveloped viruses (including HIV, Ebola, and parainfluenza) from escaping their membranes in the lab, a finding that could lead to novel treatments for many viral diseases.
    Linker histones tune the length and shape of chromosomes
    A new study finds that proteins known as linker histones control the complex coiling process that determines whether DNA will wind into long and thin chromosomes, made up of many small loops, or short and thick chromosomes with fewer large loops.
    Hospital hallway installation honors 11 women scientists at Rockefeller
    Uncovering the chemical composition of histones and innovating addiction treatment are only two of the accomplishments of the women scientists featured in a new photographic display.
    A refurbished pharmacy supports research trials at Rockefeller
    A new pharmacy with clean room and other features makes it possible for pharmacists to prepare highly specialized compounds and sterile injectable drugs for use in clinical research.
    Three Rockefeller researchers are named HHMI investigators
    Daniel Kronauer, who studies evolution in insect societies, Daniel Mucida, who examines mucosal immunology, and Vanessa Ruta, who investigates neural circuits that underlie innate and learned behaviors, are among 33 scientists nationwide to receive this designation.
    Rockefeller leads global university ranking in measure of top cited publications
    An international ranking of research institutions by U-Multirank placed Rockefeller first in a measure of its impact based on citations.
    Rockefeller postdoc, Luka Mesin, named a Blavatnik Regional Award Finalist
    Mesin, a member of the Victora Lab, receives the honor for developing novel techniques to better understand how B cells in the immune system mature and evolve to create antibodies to fight off pathogens.
    Could future coronavirus variants fully dodge our immune system?
    Studying dozens of naturally occurring and laboratory-selected mutations in SARS-CoV-2, researchers found that the virus will need to pull off a genetic feat to become fully resistant to antibodies.
    Rockefeller faculty member, Leslie B. Vosshall, named vice president and chief scientific officer of the Howard Hughes Medical Institute
    Vosshall will join the leadership team at HHMI, a major philanthropy that supports basic biomedical scientists and educators.
    Pamela Björkman wins the 2021 Pearl Meister Greengard Prize
    Pamela J. Björkman, who discovered key aspects of the immune system that are helping to direct better treatment for infection from viruses and other diseases, will receive the prize in a virtual ceremony hosted by Rockefeller on September 30.
    Frames of Mind 
    We think of brains as computers—stimulus in, action out. But they’re far more finicky than any iMac. Easily swayed by underlying internal states such as hunger, aggression, or arousal, our neurons are capable of incredible flexibility. For neuroscientists, it’s yet another wrinkle in understandin...
    Rockefeller saliva test for COVID-19 outperforms commercial swab tests
    The DRUL saliva assay is safer, more comfortable, and less expensive than comparable COVID screening tools. Now a new study demonstrates that it is at least as sensitive as swab tests, too.
    Study reveals how ribosomes are assembled in human cells
    Three-dimensional images of human small ribosomal subunits offer the most detailed explanation for how the cell's protein-making machines are assembled.
    Missing immune molecule may explain why some HPV patients sprout giant horn-like growths
    Scientists identified a mutation that affects one’s reaction to HPV by decreasing the production of CD28, a vital molecule within the immune system.
    Guido Guidotti, a biochemist and one of Rockefeller’s early graduates, has died
    Guido Guidotti, who made contributions to biochemistry and performed pioneering work during his study in the lab of Lyman Craig, has died at the age of 87.
    New microscopy technique reveals activity of one million neurons across the mouse brain
    Using light beads microscopy, researchers can now capture images of a vast number of cells across different depths in the brain at high speed, with unprecedented clarity.
    The physics behind a water bear's lumbering gait
    Animals as small and soft as tardigrades seldom have legs and almost never bother walking. But a new study finds that water bears propel themselves through sediment and soil on eight stubby legs, in a manner resembling that of insects 500,000 times their size.
    Natural infection versus vaccination: Differences in COVID antibody responses emerge
    People who recover from COVID-19 may have better protection than those who received a vaccine, but the benefits of natural immunity do not outweigh the very real risk of disability and death from contracting the disease.
    Emeritus Professor Te Piao King, expert on allergens, has died
    Te Piao King, a Rockefeller biochemist whose pioneering research greatly advanced the science and treatment of allergic reactions, died August 18 at the age of 90.  
    The common thread in severe COVID-19 
    New studies point to a single molecular explanation for 20 percent of critical COVID-19 cases: insufficient or defective type I interferons.
    Lonely flies, like many humans, eat more and sleep less
    If COVID-19 lockdowns scrambled your sleep schedule and stretched your waistline, you're not alone. Fruit flies quarantined in test tubes sleep too little and eat too much after only one week of social isolation.
    Study reveals how smell receptors work
    The first-ever molecular images of an olfactory receptor at work answer decades-old questions about odor recognition.
    When ant colonies get bigger, new foraging behavior emerges
    By increasing the size of ant colonies bit by bit, scientists identified the mechanism responsible for the evolution of mass raiding behavior.
    How cells draw on memories of past inflammation to respond to new threats
    A new study uncovers a near-universal mechanism behind this phenomenon, known as inflammatory memory.
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