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Brain disease transmitted by tick bites may be treatable

The virus that causes tick-borne encephalitis appears to trick the immune system, misdirecting it into producing inferior antibodies. But new research shows some people produce more potent antibodies, providing hope for treatment.

Immunologist Katharine Hsu is named director of the Tri-Institutional M.D.-Ph.D. program

The joint program between Weill Cornell Medicine, The Rockefeller University, and Memorial Sloan Kettering Cancer Center will be lead by Hsu, an accomplished physician-scientist who specializes in immunology research and treatment of blood cancers.

Paul Cohen, expert on fat, is promoted to associate professor

Cohen, a physician-scientist exploring obesity and metabolic disease, has conducted groundbreaking research on the complex inner workings of fat tissue.

Immunologist Daniel Mucida promoted to professor

A pioneer in the field of mucosal immunology, Mucida is unlocking the secrets of the digestive system and answering fundamental questions about the origins of human disease.

Mary Jeanne Kreek, pioneer in studies of addiction, has died

Kreek conducted landmark studies that led to the establishment of methadone as a treatment for heroin addiction. Her work not only yielded new treatments for addiction disorders, but also influenced societal attitudes toward them. She was 84.

Paula Volent is named chief investment officer

The university has named its next vice president and chief investment officer. Volent, who for decades oversaw investments at Bowdoin College, will assume stewardship of Rockefeller's endowment in August.

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How one patient’s rare mutation helped solve a mycobacterial mystery

The discovery may explain why some patients suffer more severe reactions than others—putting us one step closer to understanding how our DNA influences our susceptibility to a wide range of infectious diseases.

Financial crashes, pandemics, Texas snow: How math could predict "black swan" events

Statistical modeling may one day help scientists anticipate and manage a wide range of extreme occurrences, according to a new study.

An old antibiotic may combat drug-resistant tuberculosis

Drug-resistant strains of tuberculosis bacteria affect half a million people a year. A compound first discovered in the 1980s may be able to help.

Why male mosquitoes leave humans alone

Unlike their female counterparts, male mosquitoes have no desire to bite us. But the hardware for host-seeking is hidden in the male mosquito brain, locked behind a simple genetic switch. 

This fish is about to flip 

An elaborate set of zebrafish experiments is shining light on one of neuroscience’s greatest enigmas: How brains make decisions. By tracking neural activity, scientists can now predict a fish’s next move before it happens.

Rockefeller grants commercial license for the development of monoclonal antibodies for treatment of COVID-19

The treatment, a combination of two antibodies, has been shown highly capable of neutralizing SARS-CoV-2 in preclinical studies. Researchers hope it will give countries around the world, including developing countries, a way to control the rampant disease.

COVID-19 vaccines may need regular updates for emerging variants

Lab experiments suggest that the new strains reported in Britain, South Africa, and Brazil may blunt the potency of the Pfizer and Moderna COVID-19 vaccines. This could mean that the vaccines will need updates as the virus mutates.

Neurophysiologist Victor Wilson, 92, has died

Victor Wilson, a neurophysiologist who traced the intricate neural mechanisms that govern our balance and posture, died on January 20 at the age of 92.

Synthetic “micro lungs” could take COVID-19 research to the next level

Scientists have developed stem-cell technology to mass-produce tissue cultures resembling our breathing organs. These tissues offer a powerful model in which to study how SARS-CoV-2 wreaks havoc in the lungs and to screen for new drugs.

The immune system mounts a lasting defense after recovery from COVID-19

The study participants continued to improve their antibodies months after initial infection, potentially due to exposure to remnants of the virus hidden in the gut.

The blood may hold clues to some of COVID-19’s most mysterious symptoms

COVID-19 causes a host of diverse complications, from lung inflammation to blood clots, heart failure, and brain fog. A team of scientists believes these attributes may have a single culprit—and that findings from research on Alzheimer’s disease might give them a leg up in finding it.

Rockefeller begins testing of new COVID-19 antibody drug in people

Patients in the clinical trial will receive two highly potent antibodies against SARS-CoV-2 discovered at the university. Designed to prevent people with early COVID-19 from developing severe disease, the treatment is urgently needed as hospitals continue to be inundated by repeated surges of inf...

What Darwin never guessed 

Scientists have found that evolution isn’t always a one-way street toward specialization.

Scientists capture the moving parts of the portal to the cell’s nucleus

The proteins of the nuclear pore complex flip-flop rapidly between two orientations as they let cargo through.

Study of 50,000 people finds brown fat may protect against many diseases

People with brown fat tissue tend to burn calories more quickly, but do they also enjoy better health? Now the largest study of its kind shows that brown fat is indeed linked to reduced risk of heart disease, type 2 diabetes, and several other conditions.

Llamas immune to coronavirus, what zebrafish are thinking, and other memorable science stories of 2020 

This year's scientific endeavors included multiple attacks on SARS-CoV-2—and a lot more. Here are the most memorable science stories to come out of Rockefeller labs, from cracking the code behind specific skin cancer subtypes to understanding what goes on inside a fish brain.

As COVID-19 vaccines emerge, the search for antiviral drugs continues

Scientists are digging through drug libraries of 430,000 compounds, in pursuit of an antiviral drug that can stop the novel coronavirus in its tracks.

A mediocre mutator 

Scientists developed a method to safely examine the ability of SARS-CoV-2 to escape future drugs or vaccines by mutating. Their initial results are reassuring.

Royalty Pharma and Pablo and Almudena Legorreta Support Development of Antibody-Based COVID-19 Therapy at The Rockefeller University

Royalty Pharma and The Rockefeller University announced generous gifts totaling $5,760,000 from Royalty Pharma and Pablo and Almudena Legorreta.

Scientists map the network of SARS-CoV-2’s helpers inside human cells

The virus must hijack a more than a hundred human proteins to replicate inside a cell. One of them stands out because it is an absolute requirement for infection by four different coronaviruses as well as by viruses that cause Zika, yellow fever, and other diseases.

Charles M. Rice formally receives 2020 Nobel Prize in a virtual ceremony

Rice was honored for research that contributed to a cure for hepatitis C. He accepted the Nobel medal and diploma at the Swedish Consulate in New York City.

Marina Caskey is promoted to professor of clinical investigation

Caskey, a clinician in the lab of Michel Nussenzweig, has spent the last decade working on clinical studies of experimental immune-based vaccines and therapies.

New five-year fundraising campaign has already received $200 million in gifts

The $675 million Campaign for the Convergence of Science and Medicine, launched July 1, 2019, aims to fulfill the priorities identified in the university’s 2020-2024 strategic plan.

What bats can teach us about COVID-19

Unlike most humans, bats are naturally resistant to coronavirus infection. Researchers are now searching their genomes for clues that might explain why SARS-CoV-2 can cause devastating disease in our own species.