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Proceedings of the National Academy of Sciences USA online: August 26, 2013

Proceedings of the National Academy of Sciences USA online: August 26, 2013 H3R42me2a is a histone modification with positive transcriptional effects Fabio Casadio, Xiangdong Lu,  Samuel B. Pollock, Gary LeRoy, Benjamin A. Garcia, Tom W. Muir, Robert G. Roeder and C. David  Allis

Journal of Experimental Medicine 210: 1,871-1,888 (8-26-13)

Journal of Experimental Medicine 210: 1,871-1,888 Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract Darren Ruane, Lucas Brane, Bernardo Sgarbi Reis, Cheolho Cheong, Jordan Poles, Yoonkyung Do, Hongfa Zhu, Klara Velinzon, Jae-Hoon Choi, Natalie Studt, Lloyd ...

Immunity 39: 245-258 (8-22-13)

Immunity 39: 245-258 Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies Tongqing Zhou, Jiang Zhu, Xueling Wu, Stephanie Moquin, Baoshan Zhang, Priyamvada Acharya, Ivelin S. Georgiev, Han R. Altae-Tran, G...

Cell online: August 20, 2013

Cell online: August 20, 2013 Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans Steven W. Flavell, Navin Pokala, Evan Z. Macosko, Dirk R. Albrecht, Johannes Larsch and Cornelia I. Bargmann

Cell 154: 748-762 (8-15-13)

Cell 154: 748-762 Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA Pu Gao, Manuel Ascano, Thomas Zillinger, Weiyi Wang, Peihong Dai, Artem A. Serganov, Barbara L. Gaffney, Stewart  Shuman, Roger A. Jones, Liang Deng, Gunther Hartmann, Winfr...
Science News

New technique in RNA interference cuts time and cost in genetic screens

There is a new contender in the field of gene discovery, and it’s giving knockout mice a run for their money. Researchers at The Rockefeller University have shown that a new technique using RNA interference is able to find genes that cause epidermal tumor growth in months rather than the decades ...
Campus News

Structural biologist, interested in ribosome assembly, to join Rockefeller faculty

At the heart of the central dogma of biology — that DNA makes RNA and RNA makes proteins — is the ribosome. Ribosomes serve as a cell’s protein factories, linking amino acids together into complex proteins according to instructions encoded in the cell’s messenger RNAs. It’s a process that ...

Nature online: August 14, 2013

Nature online: August 14, 2013 RNAi screens in mice identify physiological regulators of oncogenic growth Slobodan Beronja, Peter Janki, Evan Heller, Wen-Hui Lien, Brice E. Keyes, Naoki Oshimori and Elaine Fuchs

Proceedings of the National Academy of Sciences USA online: August 8, 2013

Proceedings of the National Academy of Sciences USA online: August 8, 2013 UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling Carlene Moore, Ferda Cevikbas, H. Amalia Pasolli, Yong Chen, Wei Kong, Cordula Kempkes,...
Science News

Researchers find molecule that causes sunburn pain

The painful, red skin that comes from too much time in the sun is caused by a molecule abundant in the skin’s epidermis, a new study published in the Proceedings of the National Academy of Sciences shows. Blocking the molecule, called TRPV4, greatly protects against the painful effects of sunburn...

Nature Immunology online: August 4, 2013

Nature Immunology online: August 4, 2013 Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens Ansuman T. Satpathy, Carlos G. Briseño, Jacob S. Lee, Dennis Ng, Nicholas A. Manieri, Wumesh K.C., Xiaodi Wu, Stephanie R. Thomas, Wan-...

In the News

Engineering in Service of a Dark Art   "Biology graduate student Tom McDonagh, of Rockefeller University, likes working with light. For his Ph.D. he built a spinning microscope that uses centrifugal force to test the gripping power of different molecules. McDonagh also innovates with light outsid...

Nature online: July 31, 2013

Nature online: July 31, 2013 Completion of the entire hepatitis C virus life cycle in genetically humanized mice Marcus Dorner, Joshua A. Horwitz, Bridget M. Donovan, Rachael N. Labitt, William C. Budell, Tamar Friling, Alexander Vogt, Maria Teresa Catanese, Takashi Satoh, Taro Kawai, Shizuo Akir...

Proceedings of the National Academy of Sciences USA online: July 29, 2013

Proceedings of the National Academy of Sciences USA online: July 29, 2013 Behavioral diversity in microbes and low-dimensional phenotypic spaces David Jordan, Seppe Kuehn, Eleni Katifori and Stanislas Leibler  

Proceedings of the National Academy of Sciences USA online: July 29, 2013

Proceedings of the National Academy of Sciences USA online: July 29, 2013 Behavioral diversity in microbes and low-dimensional phenotypic spaces David Jordan, Seppe Kuehn, Eleni Katifori and Stanislas Leibler  

Journal of Experimental Medicine online: July 29, 2013

Journal of Experimental Medicine online: July 29, 2013 Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood Minji Byun, Cindy S. Ma, Arzu Akçay, Vincent Pedergnana, Umaimainthan  Palendira, Jinjong Myoung, Danielle T. Avery, Yifang Liu, Avinash Abhyankar, Lazaro Lorenzo,...

Journal of Experimental Medicine online: July 29, 2013

Journal of Experimental Medicine online: July 29, 2013 Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood Minji Byun, Cindy S. Ma, Arzu Akçay, Vincent Pedergnana, Umaimainthan  Palendira, Jinjong Myoung, Danielle T. Avery, Yifang Liu, Avinash Abhyankar, Lazaro Lorenzo,...
Campus News

Convocation 2013

The 2013 Convocation awarded 17 Ph.Ds to Rockefeller graduate fellows, bringing the total number of Rockefeller alumni to 1,127. Although rain in the early afternoon forced the cancellation of the traditional academic procession from Weiss to Caspary Auditorium, it did not dampen spirits. Followi...
Campus News

David Rockefeller Fellowship awarded to neuroscientist Jason Pitts

by LESLIE CHURCH Jason Pitts wasn’t entirely sure what to do with his life after graduating from college, back in 2008. So like any good scientist facing a big question, he came up with a series of experiments. Mr. Pitts tested out several careers — from medicine to teaching to pharmaceuticals ...
Campus News

Coming soon, to The David Rockefeller Graduate Program

As the graduating class of 2013 moves on to the next stages of life and career, the Rockefeller community welcomes the incoming group of graduate fellows. There were 719 applications received this year, and after careful consideration by the admissions committee, 69 applicants were offered admiss...
Campus News

Four leaders in science and philanthropy given honorary degrees

by LESLIE CHURCH At this year’s Convocation ceremony, honorary degrees were awarded to four proponents of basic science who have made invaluable contributions to science, through research and philanthropy. Günter Blobel, John D. Rockefeller Jr. Professor at Rockefeller; Paul Greengard, Vincent A...
Campus News

Marraffini and Tavazoie recognized for excellence in teaching

Two Rockefeller faculty members were honored at the Convocation luncheon with this year’s Distinguished Teaching Awards: Assistant Professor Luciano Marraffini and Leon Hess Assistant Professor Sohail Tavazoie. It is the 10th year that the awards, which recognize excellence in and dedication to t...
Campus News

Pinar Ayata

Pinar Ayata Presented by Nathaniel Heintz B.S., Sabanci University Decoding 5hmC as an Active Chromatin Mark in the Brain and its Link to Rett Syndrome           As I stand here before you, I feel a real sense of pride in Pinar Ayata’s achievements. This young woman has so many facets ...
Campus News

Nicole Bowles

Nicole Bowles Presented by Bruce S. McEwen B.A., New York University Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation           Nicole Bowles graduated from New York University in May 2008 with a B.S. in chemistry and minor in m...
Campus News

Fabio Casadio

Fabio Casadio Presented by C. David Allis B.S., M.S., University of Bologna Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone  Modification with Positive Transcriptional Effects           Fabio Casadio came to my lab from Italy, which is relevant...
Campus News

Emily Conn Gantman

Emily Conn Gantman Presented by Robert B. Darnell B.A., University of Pennsylvania RNA Dynamics in T Cell Activation             Emily Conn Gantman came to The Rockefeller University as an extraordinarily promising young talent and emerged an outstanding multi-disciplined scientist, huma...
Campus News

Teresa Davoli

Teresa Davoli Presented by Sidney Strickland on behalf of Titia de Lange B.S., University of Pisa M.S., San Raffaele University Telomere-driven Tetraploidy and its Relevance to Cancer           I will read remarks prepared by Titia de Lange who unfortunately couldn’t be here today: It ...
Campus News

Paul Daniel Dossa

Paul Daniel Dossa Presented by Howard C. Hang B.S., Harvey Mudd College Analysis of Small Molecule Inhibitors Aimed at Bacterial Virulence             Humans are constantly exposed to bacteria. The colonization of our tissues with beneficial microbes after birth can help our metabolism...
Campus News

Amy Grunbeck

Amy Grunbeck Presented by Thomas P. Sakmar B.S., Dickinson College Application of Genetically-encoded Photoactivatable Crosslinkers to Map Ligand-binding Sites on G Protein Coupled Receptors           It is a privilege to present to you Amy Grunbeck. Before coming to New York, Amy receiv...
Campus News

Adam Michael Knepp

Adam Michael Knepp Presented by Thomas P. Sakmar B.S., Stanford University Studies of G Protein Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches           It is a privilege to present to you Adam Knepp. Adam’s thesis research focused on h...
Campus News

Suchit H. Patel

Suchit H. Patel * Presented by Sidney Strickland of behalf of A. James Hudspeth B.S., New York Institute of Technology Frequency Selectivity of Synaptic Exocytosis in Hair Cells of the Bullfrog’s Amphibian Papilla           I will read remarks prepared by Jim Hudspeth who unfortunately ...
Campus News

Dennis Justin Spencer

Dennis Justin Spencer * Presented by Vincent A. Fischetti B.S., Morehouse College Determining the Phenotypic and Genotypic Response Exhibited by Streptococcus Pyogenes at the Human Palatine Tonsil           A child that gets a group A streptococcal infection that is adequately treated wil...
Campus News

Chan Lek Tan

Chan Lek Tan Presented by Paul Greengard B.A., Christ’s College, University of Cambridge Tuning of Neuronal Excitation by a Brain Specific MicroRNA miR-128: From Targets to Behavior           Chan Lek Tan is a brave young traveler on a historic path to conquer the Wild West. Born in Mal...
Campus News

Sarah Van Driesche

Sarah Van Driesche Presented by Robert B. Darnell on behalf of himself and Jennifer C. Darnell B.A., Wellesley College Mechanism of Translational Control by the Fragile X Mental Retardation Protein and Creation of the FMRP cTAG Mouse           Sarah Van Driesche came to The Rockefeller Un...
Campus News

Amy Wells Quinkert

Amy Wells Quinkert Presented by Bruce S. McEwen on behalf of Donald W. Pfaff B.S., Rhodes College Deep Brain Stimulation to Increase Generalized Arousal in Intact Mice and a Mouse Model of Traumatic Brain Injury           Don Pfaff had an obligation that prevents him from being here. As a...
Campus News

Laura Winzenread

Laura Winzenread Presented by Leslie B. Vosshall on behalf of Cori Bargmann B.S., University of Kansas An Analysis of Synaptotagmins in Caenorhabditis elegans             Cori Bargmann was unable to be here today and I am pleased to present Laura Winzenread on her behalf. To me, Laura ...

Science online: July 25, 2013

Science online: July 25, 2013 T follicular helper cell dynamics in germinal centers Ziv Shulman, Alexander D. Gitlin, Sasha Targ, Mila Jankovic, Giulia Pasqual, Michel C. Nussenzweig and Gabriel D. Victora

Proceedings of the National Academy of Sciences USA online: July 23, 2013

Proceedings of the National Academy of Sciences USA online: July 23, 2013 Cost of rNTP/dNTP pool imbalance at the replication fork Nina Y. Yao, Jeremy W. Schroeder, Olga Yurieva, Lyle A. Simmons and Mike E. O’Donnell

Proceedings of the National Academy of Sciences USA online: July 22, 2013

Proceedings of the National Academy of Sciences USA online: July 22, 2013 Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1 Craig S. Pace, Ruijiang Song, Christina Ochsenbauer, Chasity D. Andrews, David  Franco, Jian Yu...

Nature Biotechnology online: July 21, 2013

Nature Biotechnology online: July 21, 2013 DNA targeting specificity of RNA-guided Cas9 nucleases Patrick D. Hsu, David A. Scott, Joshua A. Weinstein, F. Ann Ran, Silvana Konermann, Vineeta  Agarwala, Yinqing Li, Eli J. Fine, Xuebing Wu, Ophir Shalem, Thomas J. Cradick, Luciano A. Marraffini, Gan...

The EMBO Journal online: July 19, 2013

The EMBO Journal online: July 19, 2013 SAMHD1-dependent retroviral control and escape in mice Jan Rehwinkel, Jonathan Maelfait, Anne Bridgeman, Rachel Rigby, Bruce Hayward, Rachel A. Liberatore, Paul D. Bieniasz, Greg J. Towers, Luis F. Moita, Yanick J. Crow, David T. Bonthron and Caetano Reis e ...

Cell 154: 377-390 (7-18-13)

Cell 154: 377-390 Marking and measuring single microtubules by PRC1 and kinesin-4 Radhika Subramanian, Shih-Chieh Ti, Lei Tan, Seth A. Darst and Tarun M. Kapoor

Cell 154: 297-310 (7-18-13)

Cell 154: 297-310 SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53 Zhanyun Tang, Wei-Yi Chen, Miho Shimada, Uyen T.T. Nguyen, Jaehoon Kim, Xiao-Jian Sun, Toru Sengoku, Robert K. McGinty, Joseph P. Fernandez, Tom W. Muir and Robert G. R...

Proceedings of the National Academy of Sciences USA 110: 11,797-11,802 (7-16-13)

Proceedings of the National Academy of Sciences USA 110: 11,797-11,802 Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products Jeremy G. Owen, Boojala Vijay B. Reddy, Melinda A. Ternei, Zachary Charlop-Powers, Paula Y...

Cell online: July 16, 2013

Cell online: July 16, 2013 KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors Joshua C. Black, Amity L. Manning, Capucine Van Rechem, Jaegil Kim, Brendon Ladd, Juok Cho, Cristiana M. Pineda, Nancy Murphy, Danette L. Daniels, Cristina Montagna...

Genes and Development 27: 1596-1609 (7-15-13)

Genes and Development 27: 1596-1609 A TAF4 coactivator function for E proteins that involves enhanced TFIID binding Wei-Yi Chen, Jinsong Zhang, Huimin Geng, Zhimei Du, Tomoyoshi Nakadai and Robert G. Roeder

Proceedings of the National Academy of Sciences USA online: July 15, 2013

Proceedings of the National Academy of Sciences USA online: July 15, 2013 Structure and function of CarD, an essential mycobacterial transcription factor Devendra B. Srivastava, Katherine Leon, Joseph Osmundson, Ashley L. Garner, Leslie A.  Weiss, Lars F. Westblade, Michael S. Glickman, Robert La...

Molecular Psychiatry online: July 9, 2013

Molecular Psychiatry online: July 9, 2013 Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition J. Wei, E.Y. Yuen, W. Liu, X. Li, P. Zhong, I.N. Karatsoreos, B.S. McEwen and Z. Yan

Immunity online: July 9, 2013

Immunity online: July 9, 2013 T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response Eugenio A. Carrera Silva, Pamela Y. Chan, Leonel Joannas, Andrea E. Errasti, Nicola Gagliani, Lidia Bosurgi, Maurice Jabbour, Anthony Perry, Fay...

Proceedings of the National Academy of Sciences USA online: July 8, 2013

Proceedings of the National Academy of Sciences USA online: July 8, 2013 Stochastic expression and epigenetic memory at the yeast HO promoter Qian Zhang, Youngdae Yoon, Yaxin Yu, Emily J. Parnell, Juan Antonio Raygoza Garay, Michael M. Mwangi, Frederick R. Cross, David J. Stillman and Lu Bai

In the News

U.S. university heads in Israel to establish academic ties   “I was amazed to watch two paraplegics walk independently using the ReWalk robotic device and moved when they showed how leaving their wheelchairs has transformed their lives,” said Rockefeller University President Marc Tessier-Lavig...

PLoS Biology online: July 2, 2013

PLoS Biology online: July 2, 2013 Quantitative control of protein s-palmitoylation regulates meiotic entry in fission yeast Mingzi M. Zhang, Pei-Yun Jenny Wu, Felice D. Kelly, Paul Nurse and Howard C. Hang

Proceedings of the National Academy of Sciences USA online: July 1, 2013

Proceedings of the National Academy of Sciences USA online: July 1, 2013 Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II Xin Liu, Tarun M. Kapoor, James K. Chen and Morgan Huse
Proceedings of the National Academy of Sciences USA online: July 1, 2013 Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells Sonja C. Stadler, C. Theresa Vincent, Victor D. Fedorov, Antoni...

In the news

All the buzz about mosquitoes   "[Leslie Vosshall's] dedication to her work seems jaw-droppingly insane, especially at feeding times."

Nature online: June 30, 2013

Nature online: June 30, 2013 A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis Xiao-Jian Sun, Zhanxin Wang, Lan Wang, Yanwen Jiang, Nils Kost, T. David Soong, Wei-Yi Chen, Zhanyun Tang, Tomoyoshi Nakadai, Olivier Elemento, Wolfgang Fischle, Ari Melnic...
Campus News

Rockefeller president joins U.S. university leaders in Israel to explore collaborative opportunities

A delegation of presidents and chancellors from top U.S. universities, including Rockefeller’s Marc Tessier-Lavigne, travel to Israel this week to explore opportunities for bilateral academic partnerships and collaboration. The visit has been arranged by Project Interchange, a non-profit educatio...
Awards and Honors

James E. Darnell Jr. elected to membership in American Philosophical Society

James E. Darnell Jr., Vincent Astor Professor Emeritus, has been elected to the American Philosophical Society in the biological sciences. The American Philosophical Society is an honorary society that elects new members each year who have shown extraordinary accomplishments in their fields. Foun...

Proceedings of the National Academy of Sciences USA 110: 10,598-10,603 (6-25-13)

Proceedings of the National Academy of Sciences USA 110: 10,598-10,603 Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues Anthony P. West, Jr., Louise Scharf, Joshua Horwitz, Florian Klein, Michel C.  Nussenzweig and Pamela J....
Science News

Scientists identify gene that regulates stem cell death and skin regeneration

Stem cells, known for their ability to self-renew and differentiate into any kind of tissue, are considered by many scientists in the field to be immortal. But there are signs that programmed death of stem cells is important for their regulation. New research from scientists at Rockefeller Univer...
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