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Hunting for TB's most vulnerable genes

Not every gene that's essential in tuberculosis is also vulnerable to attack. A new study ranks essential genes by vulnerability, allowing researchers to better prioritize future drug targets.

Putting the brakes on immune reactions

Helper T cells may play a dual role in the immune system, both encouraging and suppressing the process by which B cells mature.

Identifying the spark of desire in fruit flies

In Drosophila’s neural circuitry for courtship, researchers discover a configuration that enables a male fruit fly to be persistent, yet flexible in his pursuit of a female.

Purnell Choppin, pioneering virologist, has died

Purnell Choppin, a physician, virologist, and scientific administrator who performed pioneering research on viruses at The Rockefeller University and later exerted a powerful influence on biomedical research as president of the Howard Hughes Medical Institute, has died at the age of 91.

Scientists discover a new class of neurons for remembering faces

Our brains have sensory cells, which process the faces that we see, and memory cells dedicated to storing data from person encounters. But until now, a hybrid neuron capable of linking vision to memory—and explaining how we recall familiar faces—remained elusive.

Robert G. Roeder named the 2021 Kyoto Prize laureate in basic sciences

Roeder, a pioneer in the field of gene regulation and expression, is being honored for revealing the molecular mechanisms of transcriptional regulation.

Convocation 2021 caps a year like no other

For Rockefeller’s class of 2021, it has been a year with both challenges and accomplishments.

Toward the first drug to treat a rare, lethal liver cancer

After scouring more than 5,000 compounds, scientists have identified several new classes of therapeutics that may help treat fibrolamellar carcinoma.

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A missing antibody molecule may indicate when dengue will become deadly

The antibody's altered structure helps explain an enduring mystery of dengue—why only a fraction of those infected will develop severe disease.

How CRISPR promotes antibiotic resistance in bacteria

Whenever a cell uses CRISPR to defend itself, there's a chance of mutations creeping into its genetic code. Some of these mutations are harmless; others kill the cell. But fortuitous mutations can occasionally render major human pathogens, such as Staphylococcus aureus, antibiotic resistant.