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The rockefeller university

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Displaying 150 of 2909 articles.
Rockefeller issues license for the development of novel anti-inflammatory drug
The novel compound, discovered in Jan L. Breslow’s lab and now licensed to Bridge Medicines, will be designed to treat immune-mediated diseases without harming the rest of the immune system.
Rockefeller's Charles M. Rice honored with Nobel Prize for research that contributed to a cure for hepatitis C
Rice will receive the 2020 Nobel Prize in Physiology or Medicine for research that led to a cure for hepatitis C, a viral disease affecting 170 million people worldwide. His lab worked on the virus for three decades and became the first to produce a version of it that could be grown and studied i...
Cancer cells use nerve-cell tricks to spread from one organ to the next
New research suggests that breast and lung tumors metastasize by hijacking a neural signaling pathway, potentially opening the door to better diagnostics and treatments.
Microbes in the gut may influence metabolism
A growing number of studies find that microbes in the gut directly influence biological processes from bowel movements to behavior. New research reveals how they impact levels of glucose in the blood.
Scientists uncover antiviral protein that blocks coronavirus infection
New research identifies a protein that blocks infection by SARS-CoV-2, the coronavirus that causes COVID-19, along with several other types. The findings could inform treatment strategies and help us better prepare for future outbreaks.
Study uncovers the molecular events by which popular antidepressants work
Scientists have outlined a molecular program by which serotonin reuptake inhibitors reshape the brain to alleviate depression. Their findings provide clues for how to make better and faster-acting versions of these drugs.
Will SARS-CoV-2 escape future drugs by mutating? The answer may be a nuanced “no.”

Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potent...

How toothless mock viruses could advance research on COVID-19
Scientists have engineered four viruses resembling SARS-CoV-2 to enable faster and safer research on vaccines and treatments.
How neurons in body fat grow to boost calorie-burning capacity
Scientists have found that a hormone tells the brain to dramatically restructure neurons embedded in fat tissue.  Their work widens our understanding of how the body regulates its energy consumption, and how obesity might be treated in the future.
Why memory-forming neurons are vulnerable to Alzheimer's
Scientists have used advanced technology to “micro-dissect” the first brain cells to perish in Alzheimer’s disease. The result is a short list of genes that could represent new drug targets.
How antibodies from llamas may lead to COVID-19 treatment
Llamas make antibodies that are much smaller than their human counterparts, yet still potent. Scientists hope that future drugs based on these molecules could provide new weapons against SARS-CoV-2.
Unique mutation reveals a new role for well-known DNA-repair gene
The discovery of a rare mutation in BRCA2, commonly known as the breast cancer gene, has shed new light on how cells safeguard their genetic material.
 
Study reveals first evidence inherited genetics can drive cancer’s spread
Scientists have long struggled to understand what drives a tumor to seed itself elsewhere in the body. New research implicates our own pre-existing genetics.
Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19
The condition resembles a rare childhood illness, Kawasaki disease. Researchers are analyzing blood samples to find genetic clues to what might be causing it.
The gene hunt to explain why some young, healthy people die from COVID-19
People under 50 without preexisting conditions typically develop mild symptoms of coronavirus infection—but there are exceptions. Researchers are working to identify rare genetic variations that may explain why some in this group have succumbed to the disease.
Rockefeller scientists launch a broad range of studies into novel coronavirus
Over 130 scientists in 18 labs are conducting research to advance the development of new, urgently needed approaches for the prevention and treatment of COVID-19.
Small containers inside cells might offer new targets for cancer treatment
For reasons that have long been unclear, cells stop dividing when the pH rises inside tiny cellular compartments called lysosomes. Now scientists have found an explanation for this phenomenon, with potential implications for drug development.
Researchers discover a new mechanism in childhood kidney cancer
A problem in reader proteins that identify which gene is up for expression may cause normal cells to turn malignant during development.
Scientists develop new method that predicts vulnerability to stress
Researchers have identified a set of biological factors in mice that seem to determine one's ability to bounce back from a traumatic event, and provide preliminary evidence that a naturally-occurring substance may help boost resiliency in the face of stressful situations.
Study sheds new light on how epigenetic events might spur disease
Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
The pathway to Parkinson’s takes a surprising twist
A new study finds that neurons affected in Parkinson’s disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wreaks havoc in the brain, as well as ideas for new treatments.
C. David Allis elected to the National Academy of Medicine
Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.
New research raises prospect of better anti-obesity drugs
Scientists have found a group of brain cells that influence body mass in two ways, by controlling how much we eat as well as how much energy we burn. The findings could lead to new drugs to help people shed weight.
New molecular diagnostics test could help guide lupus treatments
A tool that detects glitches in gene expression could help doctors tailor treatments for lupus-related kidney damage.
New compounds could be used to treat autoimmune disorders
In autoimmune disorders, the body’s defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions.
Researchers find genetic link to tuberculosis
Rockefeller scientists have identified a genetic condition that makes people prone to developing tuberculosis. In a British population, they found that the condition underlies one percent of cases of the disease—a finding that may ultimately lead to new treatment options.
New hope for treating a childhood brain cancer
Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors.
New approach to treating gastrointestinal disease patches up leaky intestines
Researchers have discovered a new compound that helps fortify the intestine's inner lining, which becomes porous in inflammatory bowel diseases.  
Scientists find brain mechanism that naturally combats overeating
Studying a brain region involved in memory, researchers discovered a set of neurons that help mice control their appetite.
Researchers discover a common link among diverse cancer types
Some cancers have been traced to changes in histones, proteins responsible for packaging DNA and regulating genes. Now, research from Rockefeller scientists shows that, among tumors, mutations to these proteins are a lot more common than previously suspected.
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