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Displaying 148 of 2857 articles.
A mouse lung with metastases
Science News

Cancer cells use nerve-cell tricks to spread from one organ to the next

New research suggests that breast and lung tumors metastasize by hijacking a neural signaling pathway, potentially opening the door to better diagnostics and treatments.
A cross section of the colon with enteric neurons highlighted
Science News

Microbes in the gut may influence metabolism

A growing number of studies find that microbes in the gut directly influence biological processes from bowel movements to behavior. New research reveals how they impact levels of glucose in the blood.
Science News
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In Brief

Scientists uncover antiviral protein that blocks coronavirus infection

New research identifies a protein that blocks infection by SARS-CoV-2, the coronavirus that causes COVID-19, along with several other types. The findings could inform treatment strategies and help us better prepare for future outbreaks.
Mouse cortical neurons
Science News

Study uncovers the molecular events by which popular antidepressants work

Scientists have outlined a molecular program by which serotonin reuptake inhibitors reshape the brain to alleviate depression. Their findings provide clues for how to make better and faster-acting versions of these drugs.
coronavirus-escape-study-Bieniasz
Science News

Will SARS-CoV-2 escape future drugs by mutating? The answer may be a nuanced “no.”

Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potent...

A neutralizing antibody blocks the entry of a surrogate virus
Science News

How toothless mock viruses could advance research on COVID-19

Scientists have engineered four viruses resembling SARS-CoV-2 to enable faster and safer research on vaccines and treatments.
sympathetic innervation of adipose tissue
Science News

How neurons in body fat grow to boost calorie-burning capacity

Scientists have found that a hormone tells the brain to dramatically restructure neurons embedded in fat tissue.  Their work widens our understanding of how the body regulates its energy consumption, and how obesity might be treated in the future.
Memory-forming neurons (green) in the brain
Science News

Why memory-forming neurons are vulnerable to Alzheimer's

Scientists have used advanced technology to “micro-dissect” the first brain cells to perish in Alzheimer’s disease. The result is a short list of genes that could represent new drug targets.
llamas participating in research
Science News

How antibodies from llamas may lead to COVID-19 treatment

Llamas make antibodies that are much smaller than their human counterparts, yet still potent. Scientists hope that future drugs based on these molecules could provide new weapons against SARS-CoV-2.
BRCA2 mutation
Science News

Unique mutation reveals a new role for well-known DNA-repair gene

The discovery of a rare mutation in BRCA2, commonly known as the breast cancer gene, has shed new light on how cells safeguard their genetic material.
 
Immune cell clusters
Science News

Study reveals first evidence inherited genetics can drive cancer’s spread

Scientists have long struggled to understand what drives a tumor to seed itself elsewhere in the body. New research implicates our own pre-existing genetics.
Kawasaki disease
Science News

Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19

The condition resembles a rare childhood illness, Kawasaki disease. Researchers are analyzing blood samples to find genetic clues to what might be causing it.
DNA code on screen
Science News

The gene hunt to explain why some young, healthy people die from COVID-19

People under 50 without preexisting conditions typically develop mild symptoms of coronavirus infection—but there are exceptions. Researchers are working to identify rare genetic variations that may explain why some in this group have succumbed to the disease.
Biosafety Level 3
Science News

Rockefeller scientists launch a broad range of studies into novel coronavirus

Over 130 scientists in 18 labs are conducting research to advance the development of new, urgently needed approaches for the prevention and treatment of COVID-19.
Image of lysosomes
Science News

Small containers inside cells might offer new targets for cancer treatment

For reasons that have long been unclear, cells stop dividing when the pH rises inside tiny cellular compartments called lysosomes. Now scientists have found an explanation for this phenomenon, with potential implications for drug development.
Wilms tumor
Science News

Researchers discover a new mechanism in childhood kidney cancer

A problem in reader proteins that identify which gene is up for expression may cause normal cells to turn malignant during development.
Hippocampus microscopy
Science News

Scientists develop new method that predicts vulnerability to stress

Researchers have identified a set of biological factors in mice that seem to determine one's ability to bounce back from a traumatic event, and provide preliminary evidence that a naturally-occurring substance may help boost resiliency in the face of stressful situations.
Science News
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In Brief

Study sheds new light on how epigenetic events might spur disease

Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
dopamine neurons
Science News

The pathway to Parkinson’s takes a surprising twist

A new study finds that neurons affected in Parkinson’s disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wreaks havoc in the brain, as well as ideas for new treatments.
C. David Allis
Campus News, Awards and Honors

C. David Allis elected to the National Academy of Medicine

Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.
Brainstem neurons
Science News

New research raises prospect of better anti-obesity drugs

Scientists have found a group of brain cells that influence body mass in two ways, by controlling how much we eat as well as how much energy we burn. The findings could lead to new drugs to help people shed weight.
Science News
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In Brief

New molecular diagnostics test could help guide lupus treatments

A tool that detects glitches in gene expression could help doctors tailor treatments for lupus-related kidney damage.
Newly-developed molecules bind to a key enzyme pocket to inhibit its activity, and possibly prevent autoimmune responses.
Science News

New compounds could be used to treat autoimmune disorders

In autoimmune disorders, the body’s defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions.
Science News
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In Brief

Researchers find genetic link to tuberculosis

Rockefeller scientists have identified a genetic condition that makes people prone to developing tuberculosis. In a British population, they found that the condition underlies one percent of cases of the disease—a finding that may ultimately lead to new treatment options.
DIPG cells, pictured here, are generally resilient and replicate rapidly. With a dose of MI-2, however, the cells abruptly die.
Science News

New hope for treating a childhood brain cancer

Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors.
Intestine
Science News

New approach to treating gastrointestinal disease patches up leaky intestines

Researchers have discovered a new compound that helps fortify the intestine's inner lining, which becomes porous in inflammatory bowel diseases.  
Activation of hD2R neurons
Science News

Scientists find brain mechanism that naturally combats overeating

Studying a brain region involved in memory, researchers discovered a set of neurons that help mice control their appetite.
Science News
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In Brief

Researchers discover a common link among diverse cancer types

Some cancers have been traced to changes in histones, proteins responsible for packaging DNA and regulating genes. Now, research from Rockefeller scientists shows that, among tumors, mutations to these proteins are a lot more common than previously suspected.
Science News
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In Brief

Scientists find new clues about how the body stores fat

Scientists discovered a protein that plays a crucial role in regulating fatty acids, the molecules that make up body fat. This research could lead to new options for treating people with diseases associated with fatty acid buildup.
Leptin mouse
Science News

Scientists identify genetic factors that may cause some people to become obese

New research on leptin, a hormone that regulates appetite, reveals a previously unknown mechanism that may be responsible for at least 10 percent of obesity cases. The findings could help identify individuals with treatable forms of the condition.
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