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Scientists discovered a protein that plays a crucial role in regulating fatty acids, the molecules that make up body fat. This research could lead to new options for treating people with diseases associated with fatty acid buildup.

New research on leptin, a hormone that regulates appetite, reveals a previously unknown mechanism that may be responsible for at least 10 percent of obesity cases. The findings could help identify individuals with treatable forms of the condition.

Researchers have identified a rare type of cancer cell that cannot make cholesterol, a key nutrient. By targeting this deficiency, scientists may be able to develop new strategies for treating the disease.

Increasingly, bacteria do not succumb to antibiotics. Rockefeller researchers have developed a new class of antimicrobial drug, lysin, with one compound showing promising results in a clinical trial—suggesting that an alternative to antibiotics may be on the horizon.

Scientists have made the first comprehensive inventory of cells present in the human placenta of the first trimester, a stage when many pregnancy complications are thought to arise. The findings could fuel new research on conditions such as preeclampsia and pre-term birth.

Researchers have uncovered the genetic factors that make some people susceptible to Whipple's disease, an intestinal inflammatory disorder that causes diarrhea, pain, and weight loss.

Sohail Tavazoie, a physician-scientist who studies the genes that regulate a tumor’s ability to metastasize, has been promoted to professor.

Among other superpowers, stem cells have a knack for fending off viruses like dengue and zika. Scientists have gained new insight into these curious defense strategies—knowledge they say could fuel the development of drugs against a range of diseases.

A new report details three cases of secondary brain tumors in people with fibrolamellar hepatocellular carcinoma. The researchers say imaging tests could improve treatment for patients whose cancer spreads to the brain from the liver.

New research has helped explain what goes wrong in Aicardi-Goutières syndrome, a rare brain disorder. Patients with the disease have genetic abnormalities that may put their cells at risk of accidentally triggering an antiviral response.

Scientists identified mutations in a single gene that impair immunity to viruses in a region of the brain called the brain stem.

Günter Blobel, a Nobel Prize-winning Rockefeller biologist who discovered the mechanisms by which proteins are targeted for delivery to specific locations within cells, died February 18 at 81.

The symptoms of Huntington’s typically appear in middle age, but the disease may in fact originate much earlier. New research shows that a patient’s neural abnormalities may arise already during embryonic development—suggesting that treating the disease early may be beneficial.

A new treatment may help cancer patients who don't respond to traditional immunotherapy. Findings from the first-ever clinical trial reveal that it is effective in activating immune cells that kill cancer cells.

New research shows that subtle differences between bacterial strains may cause dramatic differences in outcome between people infected with the same microbe.

With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.

Scientists studying the cell’s DNA-copying machinery have discovered a molecular mechanism that helps reactivate it should it stop prematurely. Its function may prevent genetic errors like those that cause cancer.

A new study sheds light on how the body fights back against HIV by mutating the viral DNA.

Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They’ve used it to clarify what drives these tumors at the molecular level, and discover new drug concepts.

Scientists have discovered a peculiarity in the genetic code of HIV that might explain how this and other viruses evolved ways to dodge our immune system. The findings could make it possible to develop safer vaccines.

Scientists have identified a protein that many viruses require to spread within a host—a discovery that could lead to fighting diseases as varied as parainfluenza, West Nile, and Zika with a single drug. This finding could also lead to the development of treatments for emerging viruses.

Scientists found that inhibiting a regulatory protein alters the intricate signaling chemistry that is responsible for many of the disease’s symptoms. The findings provide a path to possible therapeutics for disorders associated with Fragile X.

Scientists have found unexpected differences in how male and female mice respond to stress. Their findings are raising big questions about sex discrepancies in the brain and their impact on neuropsychiatric disease.

de Lange is honored for her elucidation of the mechanism of telomere protection and the maintenance of genome stability.

Within the oldest part of the brain, scientists have found cells in charge of controlling appetite and eating. The discovery could revitalize efforts to develop drugs for obesity that make us less hungry.

Neuroscientists have taken a major step toward answering longstanding questions about how Prozac and similar drugs act in the brain. Their findings could lead to better antidepressants that don't take weeks to kick in.

New insights about gene regulation in liver cells could lead to better treatments for a common tumor type.

In the rats that roam New York City’s streets and tunnels, scientists have found a virus that resembles hepatitis C. They have used it to create the first animal model of the human disease, a breakthrough that potentially could yield a much-needed vaccine.

Jeremy M. Rock uses genetics to investigate how the microbe causes disease. He will join Rockefeller’s faculty on January 1, 2018.

Allis has received the March of Dimes Prize in Developmental Biology. The award, given to investigators whose research offers hope for the prevention and treatment of birth defects and other infant diseases, honors Allis for his groundbreaking work on gene regulation.