Replicative aging of human cells, the result of telomere shortening, is slower at physiological oxygen than at atmospheric oxygen, a difference now shown to be due to low oxygen impairing the ATM kinase response to withered telomeres.
Researchers have learned that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung.
Kivanç Birsoy is uncovering the hidden metabolic pathways that cancer cells exploit. His work could also optimize strategies for using nutrition to improve human health.
A surprising mix of inherited and de novo mutations in 60 genes contribute to 10 percent of CHD cases. Many of these same mutations also contribute to neurodevelopmental disorders including autism.
New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations.
Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.
A collaboration between Rockefeller, MSK, and Weill Cornell answers a longstanding
mystery about the basic biology of the hepatitis B virus, while also proposing a novel therapy.
