The Fisher Center is a nexus for Alzheimer’s disease research at Rockefeller. The center’s scientists use state-of-the-art technologies to expand and accelerate Alzheimer’s research and lay the foundation for new treatment strategies.
The center’s investigations build on Alzheimer’s studies conducted in Rockefeller University labs, particularly research focused on how the cells of the brain process the amyloid precursor protein (APP). Faulty regulation of APP processing — in which APP is chopped into smaller pieces during normal brain cell metabolism — is believed to contribute to the development of Alzheimer’s. Scientists in the Fisher Center work on understanding why APP can sometimes produce protein fragments that are safely secreted from the cell and at other times produce a protein called amyloid-ß, a major component of the brain plaques that are a hallmark of Alzheimer’s disease.