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In the News

How testosterone may alter the brain after exercise   “The exercise in this experiment was quite mild,” [Bruce S. McEwen] says — the equivalent of jogging at a pace at which someone could speak (or squeak) to a companion. “That’s achievable for most people,” he concludes, “and the ev...

In the News

Defusing the war of words over organic food   "Is there a less polarized way to think about the future of farming? Jesse H. Ausubel, an environmental scientist who directs the Program for the Human Environment at Rockefeller University, thinks he’s found one... His claim is that high-yield farmi...
Science News

Pearl Meister Greengard Prize to be awarded to pioneering RNA researcher Joan Steitz

Joan A. Steitz, a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases, will be awarded the 2012 Pearl Meister Greengard Prize from The Rockefeller University. The prize, which honors female scientists who have made extraordinary contributi...

Nature online: September 9, 2012

Nature online: September 9, 2012 Initiation of transcription-coupled repair characterized at single-molecule resolution Kévin Howan, Abigail J. Smith, Lars F. Westblade, Nicolas Joly, Wilfried Grange, Sylvain  Zorman, Seth A. Darst, Nigel J. Savery and Terence R. Strick
Science News

Vitamin D supplements do not improve cholesterol as previous research suggested

Vitamin D has been touted for its beneficial effects on a range of human systems, from enhancing bone health to reducing the risk of developing certain cancers. But it does not improve cholesterol levels, according to a new study conducted at The Rockefeller University Hospital. A team of scienti...

In the News

A Redoubt of Learning Holds Firm   "More broadly, [Paul Nurse] doesn’t fret about American dominance. That is just the way it is. Perhaps some cultural differences even accrue to the British side of the ledger. 'The U.S.A. has a very strong work ethic, and you keep a very close eye to the cutti...
Science News

Researchers demonstrate how ‘interfering’ RNA can block bacterial evolution

Bacteria may be simple creatures, but unlike “higher” organisms they have a neat evolutionary trick. When the going gets tough, they can simply pick up and incorporate a loose bit of genetic material from their environment. It’s instant evolution, no time-consuming mutations required. This pro...
Awards and Honors

Michael W. Young receives Massry Prize

Michael W. Young, Richard and Jeanne Fisher Professor and head of the Laboratory of Genetics, is being honored with the 2012 Massry Prize for his groundbreaking work on the molecular biology of circadian rhythms. Established by the Meira and Shaul G. Massry Foundation, the prize recognizes outsta...

Neuron 75: 585-592 (August 23, 2012)

Neuron 75: 585-592 Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans Heeun Jang, Kyuhyung Kim, Scott J. Neal, Evan Macosko, Dongshin Kim, Rebecca A. Butcher, Danna M. Zeiger, Cornelia I. Bargmann and Piali Sengupta

Proceedings of the National Academy of Sciences USA online: August 20, 2012

Proceedings of the National Academy of Sciences USA online: August 20, 2012 Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro John W. Schoggins, Marcus Dorner, Michael Feulner, Naoko Imanaka, Mary  Y. Murphy, Alexa...

Cell 150: 764-779 (August 17, 2012)

Cell 150: 764-779 The BMP inhibitor coco reactivates breast cancer cells at lung metastatic sites Hua Gao, Goutam Chakraborty, Ai Ping Lee-Lim, Qianxing Mo, Markus  Decker, Alin Vonica, Ronglai Shen, Edi Brogi, Ali H. Brivanlou and Filippo G. Giancotti

Cell Host & Microbe 12: 177-186 (August 16, 2012)

Cell Host & Microbe 12: 177-186 CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection David Bikard, Asma Hatoum-Aslan, Daniel Mucida and Luciano A. Marraffini

Proceedings of the National Academy of Sciences USA online: August 13, 2012

Proceedings of the National Academy of Sciences USA online: August 13, 2012 Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry Anastasia A. Aksyuk, Valorie D. Bowman, Bärbel Kaufmann, Christopher  Fields, Thomas Klose, Heather A. Holda...
Science News

Protein proves vital in immune response to bacteria

A team of researchers led by scientists at Rockefeller University have discovered that a protein once thought to be mainly involved in antiviral immunity is in fact more important in fighting bacterial infections and could provide new mechanisms for treating diseases like tuberculosis, which is i...

Neuron 75: 437-450 (August 9, 2012)

Neuron 75: 437-450 Muscleblind-like 2-Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy Konstantinos Charizanis, Kuang-Yung Lee, Ranjan Batra, Marianne  Goodwin, Chaolin Zhang, Yuan Yuan, Lily Shiue, Melissa Cline, Marina M. Scotti, Guangbin Xia, Ashok ...
Awards and Honors

Jean-Laurent Casanova to receive 2012 Milstein Award

Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has been named the Seymour and Vivian Milstein Award for Excellence in Interferon and Cytokine Research 2012 laureate. He will receive the prize at the annual meeting of the International Society of ...
Science News

Collaboration finds kidney disease tied to DNA damage

A research collaboration involving Rockefeller University and more than two dozen other institutions has found a link between a gene mutation and chronic kidney failure. The study, published in Nature Genetics in July, found patients who had a specific kind of kidney disease — called karyomegalic...

In the News

Growing Pains: Nations Balance Growth, Power Needs   "These days electricity is so important to industrial society that providing adequate power isn't good enough. For example, businesses that rely on the Internet simply can't afford to be without power, even for a minute. Sure, it was a nuisance...

The Journal of Experimental Medicine online: August 7, 2012

The Journal of Experimental Medicine online: August 7, 2012 Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood Melina Herman, Michael Ciancanelli, Yi-Hung Ou, Lazaro Lorenzo, Maja Klaudel-Dreszler, Elodie Pauwels, Vanessa Sancho-Shimizu, Rebeca ...

In the News

Technology: Problem or Solution?   "On the other hand, ask [Jesse Ausubel] about climate change (a subject he helped make the hot topic it is today), or overpopulation, or deforestation and you’ll get a surprisingly reassuring answer: things are getting better, we’re on the right track. It’s...
Science News

Cell 150: 533-548 (August 3, 2012)

Cell 150: 533-548 (August 3, 2012) Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling Moumita Chaki, Rannar Airik, Amiya K. Ghosh, Rachel H. Giles, Rui Chen, Gisela G. Slaats, Hui Wang, Toby W. Hurd, Weibin Zhou, Andrew Cluckey, Heon Yun...

Science online: August 2, 2012

Science online: August 2, 2012 Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency Dusan Bogunovic, Minji Byun, Larissa A. Durfee, Avinash Abhyankar, Ozden Sanal, Davood Mansouri, Sandra Salem, Irena Radovanovic, Audrey V. Grant, Parisa Adimi, Nahal Mansour...

The Journal of Clinical Investigation online: August 1, 2012

The Journal of Clinical Investigation online: August 1, 2012 Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections Amandine Crequer, Anja Troeger, Etienne Patin, Cindy S. Ma, Capucine Picard, Vincent Pedergnana, Claire Fieschi, Annick Lim, Avinash Abhyankar, Laure Gi...

Molecular Cell online: July 26, 2012

Molecular Cell online: July 26, 2012 DNA methylation dynamics during in vivo differentiation of blood and skin stem cells Christoph Bock, Isabel Beerman, Wen-Hui Lien, Zachary D. Smith, Hongcang Gu, Patrick Boyle, Andreas Gnirke, Elaine Fuchs, Derrick J. Rossi and Alexander Meissner
Science News

Starr collaboration illuminates mysterious pathway to immortality in cancer cells

Cancer cells are immortal because they circumvent failsafe mechanisms that stop out-of-control cell proliferation. One of these mechanisms – the progressive shortening of chromosomes – is prevented by replenishment of telomeres, the protective elements at the ends of chromosomes. Most cancer cel...

Journal of Experimental Medicine 209: 1469-1479 (July 23, 2012)

Journal of Experimental Medicine 209: 1469-1479 Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein Florian Klein, Christian Gaebler, Hugo Mouquet, D. Noah Sather, Clara Lehmann, Johannes F. Scheid, Za...
Awards and Honors

Jeffrey Ravetch wins 2012 Sanofi – Institut Pasteur Award

Jeffrey V. Ravetch, head of the Leonard Wagner Laboratory of Molecular Genetics and Immunology at Rockefeller University, has been given the 2012 Sanofi – Institut Pasteur Award for discovering mechanisms by which antibodies carry out their diverse biological functions. He is one of four scientis...

In the News

Could Bacteria-Fighting Viruses Replace Overused Antibiotics?   "The first trials for patient safety are expected to start this year. It is a moment that Vincent Fischetti, a 71-year-old microbiologist at the Rockefeller University, has been approaching for decades. A child of working-class paren...

Proceedings of the National Academy of Sciences USA online: July 17, 2012

Proceedings of the National Academy of Sciences USA online: July 17, 2012 Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis Masahiro Okamoto, Yasushi Hojo, Koshiro Inoue, Takashi Matsui, Suguru Kawato, Bruce S. McEwen and Hideak...

Proceedings of the National Academy of Sciences USA online: July 17, 2012

Proceedings of the National Academy of Sciences USA online: July 17, 2012 Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis Masahiro Okamoto, Yasushi Hojo, Koshiro Inoue, Takashi Matsui, Suguru Kawato, Bruce S. McEwen and Hideak...

Proceedings of the National Academy of Sciences USA 109: 11699-11704 (July 17, 2012)

Proceedings of the National Academy of Sciences USA 109: 11699-11704 Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters Liang Feng, Ernest B. Campbell and Roderick MacKinnon

Genes & Development 26: 1626-1642 (July 15, 2012)

Genes & Development 26: 1626-1642 Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain Donny D. Licatalosi, Masato Yano, John J. Fak, Aldo Mele, Sarah E. Grabinski, Chaolin Zhang and Robert B. Darnell

Nature Structural & Molecular Biology online: July 15, 2012

Nature Structural & Molecular Biology online: July 15, 2012 Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events Stamatios Liokatis, Alexandra Stützer, Simon J Elsässer, Francois-Xavier Theillet, Rebecca Klingberg, Barth van Rossum, Dirk Sc...
Campus News

Convocation 2012

  The 2012 Convocation honored one of the largest graduating classes in Rockefeller history with 40 Ph.Ds awarded, bringing the total number of Rockefeller alumni to 1,110. Celebrations included an evening reception for the graduates and their families, a luncheon, the traditional cap-and-gown p...
Campus News

Honorary degree recipients advanced knowledge of RNA function

by LESLIE CHURCH  Two pioneers in the field of molecular biology were recipients of the honorary doctor of science degree at the June 14 Convocation ceremony: Rockefeller’s own James E. Darnell Jr., Vincent Astor Professor Emeritus and head of the Laboratory of Molecular Cell Biology, and Yale U...
Campus News

Daniel Gilmer awarded David Rockefeller Fellowship

by LESLIE CHURCH Daniel Gilmer, a graduate fellow in Vincent A. Fischetti’s lab, has been awarded the 2012 David Rockefeller Fellowship, given each year to an outstanding third-year student for demonstrating exceptional promise in science and leadership. A native of Central Florida, Mr. Gilmer...
Campus News

Teaching awards honor Brivanlou and Fuchs

Ali H. Brivanlou (right), head of the Laboratory of Molecular Vertebrate Embryology, and Elaine Fuchs, head of the Laboratory of Mammalian Cell Biology and Development, were this year’s recipients of Distinguished Teaching Awards. The awards were established in 2005 to recognize outstanding indiv...
Campus News

Moritz Armbruster

B.S.E., The Cooper Union Dissecting Synaptic Vesicle Endocytosis presented by Timothy A. Ryan Moritz Armbruster was born in Stuttgart, Germany, and moved to the desert in Tempe, Arizona, when he was seven years old. Coming from a mathematically inclined family, he moved to New York and studied ...
Campus News

Pablo Ariel

Pablo Ariel Licenciado, Universidad de Buenos Aires Exploring Synaptic Vesicle Exocytosis presented by Timothy A. Ryan Pablo Ariel was born in Buenos Aires and grew up in part in the Netherlands and in part in Saudi Arabia and returned to Buenos Aires for his college work. His Ph.D. work focused ...
Campus News

Coming soon, to The David Rockefeller Graduate Program

As the Rockefeller community says goodbye to the graduating class of 2012, a new group of talented students is set to join the campus in the fall. Approximately 700 applications of potential new students were received this year, and after much deliberation by the admissions committee, that list w...

Proceedings of the National Academy of Sciences USA online: July 11, 2012

Proceedings of the National Academy of Sciences USA online: July 11, 2012 Speed, dissipation, and error in kinetic proofreading Arvind Murugana, David A. Huse and Stanislas Leibler    

Molecular Psychiatry online: July 10, 2012

Molecular Psychiatry online: July 10, 2012 Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure MN Hill, SA Kumar, SB Filipski, M Iverson, KL Stuhr, JM Keith, BF Cravatt, CJ Hillard, S Chattarji and BS McEwen

In the News

In Dieting, Magic Isn’t a Substitute for Science   "We asked Dr. Jules Hirsch, emeritus professor and emeritus physician in chief at Rockefeller University, who has been researching obesity for nearly 60 years, about the state of the research. Dr. Hirsch...wrote some of the classic papers descri...

Nature Genetics online: July 8, 2012

Nature Genetics online: July 8, 2012 FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair Weibin Zhou, Edgar A Otto, Andrew Cluckey, Rannar Airik, Toby W Hurd, Moumita Chaki, Katrina Diaz, Francis P Lach,  Geoffrey R Bennett, Heon...

Nature Neuroscience online: July 8, 2012

Nature Neuroscience online: July 8, 2012 Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth Erik Mire, Cecilia Mezzera, Eduardo Leyva-Díaz, Ana V  Paternain, Paola Squarzoni, Lisa Bluy, Mar Castillo-Paterna, María José López, Sandra Peregrín, ...

Cell 150: 136-150 (July 6, 2012)

Cell 150: 136-150 Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Catherine P. Lu, Lisa Polak, Ana Sofia Rocha, H. Amalia Pasolli, Shann-Ching Chen, Neha Sharma, Cedric Blanpain and Elaine Fuchs

Cell 150: 39-52 (July 6, 2012)

Cell 150: 39-52 Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST Peng Wu, Hiroyuki Takai and Titia de Lange
Science News

Sweat glands grown from newly identified stem cells

To date, few fundamentals have been known about the most common gland in the body, the sweat glands that are essential to controlling body temperature, allowing humans to live in the world’s diverse climates. Now, in a tour de force, researchers at The Rockefeller University and the Howard Hughes...

In the News

Waging a losing war against mosquitoes   "We had no winter in the Northeast this year, and so there's a lot of predictions from mosquito control experts that we're going to have a really huge season of high populations of mosquitoes, and so with that, more disease transmission," said Leslie Vossh...

The Lancet 379: 2500 (June 30, 2012)

The Lancet 379: 2500 Herpes in STAT1 deficiency Beáta Tóth, Leonóra Méhes, Szilvia Taskó, Zsuzsanna Szalai, Zsolt  Tulassay, Sophie Cypowyj, Jean-Laurent Casanova, Anne Puel and László Maródi

Proceedings of the National Academy of Sciences USA 109: 10564-10569 (June 26, 2012)

Proceedings of the National Academy of Sciences USA 109: 10564-10569 Scale invariance in the dynamics of spontaneous behavior Alex Proekt, Jayanth R. Banavar, Amos Maritan and Donald W. Pfaff

Proceedings of the National Academy of Sciences USA 109: 10352-10357 (June 26, 2012)

Proceedings of the National Academy of Sciences USA 109: 10352-10357 Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels Daniel Schmidt, Josefina del Mármol and Roderick MacKinnon

Proceedings of the National Academy of Sciences USA online: June 25, 2012

Proceedings of the National Academy of Sciences USA online: June 25, 2012 Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior Jennifer L. Warner-Schmidt, Eric F. Schmidt, John J. Marshall, Amanda J. Rubin, Margarita Arango-Lievano, Michael G. Kaplitt, Ines Ibañez-T...
Campus News

Board approves nine-year strategic plan

Following nearly a year of development, the university’s strategic plan titled “Transforming Biomedicine” has been approved by the Board of Trustees. The plan, which will guide the university’s activities over a nine-year period ending in 2020, was authored by a 13-member strategic planning ...
Campus News

New $600 million campaign launches

by LESLIE CHURCH With the introduction of an ambitious new strategic plan, The Rockefeller University is also embarking on a fundraising initiative, to be called the Campaign for Transforming Biomedicine. The campaign seeks to raise at least $600 million in nine years to facilitate the university...
Campus News

Nobel winnings to fund Cohn-Steinman professorship

by ZACH VEILLEUX Ralph M. Steinman, head of the Laboratory of Cellular Physiology and Immunology, died just three days before winning the Nobel Prize last year. But his legacy at the university will live on: with a gift from the Steinman family and the support of over 120 donors including many of...
Campus News

Recent computer attacks on campus target Macs, e-mail

by LESLIE CHURCH It’s not just biologists who are studying infection at Rockefeller. Computer security experts based in the IT Pavilion have been kept busy in recent months managing outbreaks of viruses and other malware on campus computers.     In June more than a dozen people on campus fe...

Cell 149: 1565-1577 (June 22, 2012)

Cell 149: 1565-1577 Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation Xinjun Zhang, Jose Garcia Abreu, Chika Yokota, Bryan T. MacDonald, Sasha Singh, Karla Loureiro Almeida Coburn, Seong-Moon Cheong, Mingzi M. Zhang, Qi-Zhuang Ye, Howard C. Hang, Hanno Steen and Xi He
Campus News

Employees honored for longtime service to university

Members of the Rockefeller faculty and staff were recognized for their service to the university with two recent events. The Employee Recognition Cocktail Reception in February honored employees who had worked at the university for 20 and 25 years. Fifty-nine employees celebrated 20 years of serv...
Campus News

Genome Center to operate at Rockefeller in interim

by LESLIE CHURCH The New York Genome Center (NYGC), the nonprofit institution set to become one of the largest bioinformatics and genomics facilities in North America, is launching its pilot lab operations at The Rockefeller University while a search is conducted for a permanent facility. Rockef...
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