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Proceedings of the National Academy of Sciences USA online: April 28, 2014

Proceedings of the National Academy of Sciences USA online: April 28, 2014 Structure of the branched intermediate in protein splicing Zhihua Liu, Silvia Frutos, Matthew J. Bick, Miquel Vila-Perelló, Galia T. Debelouchina, Seth A. Darst and Tom W. Muir

Cell 157: 636-650 (14-4-24)

Cell 157: 636-650 Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function Ender Karaca, Stefan Weitzer, Davut Pehlivan, Hiroshi  Shiraishi, Tasos Gogakos, Toshikatsu Hanada, Shalini N. Jhangiani, Wojciech Wiszniewski, Marjorie Withers, Ian M. Camp...

Proceedings of the National Academy of Sciences USA online: April 24, 2014

Proceedings of the National Academy of Sciences USA online: April 24, 2014 A model for the generation and transmission of variations in evolution Olivier Rivoire and Stanislas Leibler
Science News

Friction harnessed by proteins helps organize cell division

A football-shaped structure, known as the mitotic spindle, makes cell division possible for many living things. This piece of cellular architecture, responsible for dividing up genetic material, is in constant flux. The filaments that form it grow and shrink, while motor-like molecules burn energ...
Science News

A new web tool effectively prioritizes disease-causing genes by biological distance

A new tool, essentially a genetic navigation system that can help biologists identify connections and measure distances between human genes, has received an upgrade. Now, just as with Google Maps, anyone can access the Human Gene Connectome, without training in computational biology or the need t...
Science News

Genetically identical ants help unlock the secrets of larval fate

A young animal’s genes are not the only genes that determine its fate. The genetic identity of its caretakers matters too. Researchers suspect the interaction between the two can sway the fate of the young animal, but this complex dynamic is difficult to pin down in lab experiments. However, soci...

Cell 157: 420-432 (14-4-10)

Cell 157: 420-432 Asymmetric friction of nonmotor MAPs can lead to their directional motion in active microtubule networks Scott Forth, Kuo-Chiang Hsia, Yuta Shimamoto and Tarun M. Kapoor

Proceedings of the National Academy of Sciences USA 111: 1393-1401 (14-4-8)

Proceedings of the National Academy of Sciences USA 111: 1393-1401 Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line Aaron B. Steiner, Taeryn Kim, Victoria Cabot and A. J. Hudspeth

Nature Genetics online: April 6, 2014

Nature Genetics online: April 6, 2014 Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations Pawel Buczkowicz, Christine Hoeman, Patricia Rakopoulos, Sanja Pajovic, Louis Letourneau, Misko Dzamba, Andrew Morrison, Peter ...
Science News

Drug is identified that could block the spread of melanoma

Cancer is at its most curable when it’s caught before it spreads. That’s especially true in the case of melanoma, where survival rates can be as high as 97 percent when caught early — and as low as 15 percent if it’s not. New research at Rockefeller has now identified a promising route to sl...
Awards and Honors

Surgeon and writer Atul Gawande awarded Lewis Thomas Prize

Atul Gawande, a surgeon who has written several highly regarded books on public health, has been awarded the 2014 Lewis Thomas Prize for Writing about Science from The Rockefeller University. Gawande was honored at a ceremony in Rockefeller’s Caspary Auditorium in March. The Lewis Thomas Prize wa...
Science News

Discovery reveals protons sneak through the sodium-potassium pump

Located in the surface membrane of all animals’ cells, sodium-potassium pumps keep cells and the animals that contain them in working order. Among other things, their efforts underlie nerve signals, heart beats and muscle contractions. But as ubiquitous and essential as these pumps are, new resea...

Nature Chemical Biology online: March 30, 2014

Nature Chemical Biology online: March 30, 2014 Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark Lunzhi Dai, Chao Peng, Emilie Montellier, Zhike Lu, Yue Chen, Haruhiko Ishii, Alexandra Debernardi, Thierry Buchou, Sophie Rousseaux, Fulai Jin, Benjamin R. Sabari, Zhiyou De...

In the News

Science for the Benefit of Parents at The Rockefeller University   "Where can you find dozens of parents in a room with Nobel prize-winning scientists? At The Rockefeller University's one-of-a-kind Parents and Science initiative. Launched in 2007, the initiative helps parents learn more about res...
Awards and Honors

Titia de Lange to receive Canada Gairdner International Award

Titia de Lange, a cell biologist who studies how the ends of chromosomes are protected from damage, will be honored with the Canada Gairdner International Award, given for significant discoveries in medical science. de Lange, who is Leon Hess Professor and head of the Laboratory of Cell Biology a...

Science 343: 1370-1372 (14-3-21)

Science 343: 1370-1372 Humans can discriminate more than 1 trillion olfactory stimuli C. Bushdid, M. O. Magnasco, L. B. Vosshall and A. Keller

In the news

Your nose can smell at least 1 trillion scents   "As [Leslie] Vosshall put it: 'The world is always changing. Plants are evolving new smells. Perfume companies are making new scents. You might move to some part of the world where you’ve never encountered the fruits and vegetables and flowers tha...
Science News

Sniff study suggests humans can distinguish more than 1 trillion scents

The human sense of smell does not get the respect it deserves, new research suggests. In an experiment led by Andreas Keller, of Rockefeller’s Laboratory of Neurogenetics and Behavior, researchers tested volunteers’ ability to distinguish between complex mixtures of scents. Based on the sensitiv...

In the news

51%: The Women’s Perspective   "Dr. Cori Bargmann of Rockefeller University studies how biology, our genes and the environment we live in can affect the way we act. She is especially interested in understanding social behaviors. Believe it or not, she studies worms to examine the underlying biol...

Molecular Psychiatry online: March 11, 2014

Molecular Psychiatry online: March 11, 2014 Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram P. Svenningsson, L. Berg, D. Matthews, D. F. Ionescu, E. M. Richards, M. J. Niciu, A. ...
Awards and Honors

Nora Pencheva wins 2014 Weintraub Graduate Student Award

Nora Pencheva, a graduate fellow in Sohail Tavazoie’s Laboratory of Systems Cancer Biology, will receive a Harold M. Weintraub Graduate Student Award, one of the country’s most prestigious graduate student prizes. The award is given by the Fred Hutchinson Cancer Research Center and recognizes ou...

Science 343: 1151-1154 (14-3-7)

Science 343: 1151-1154 Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus Chasity D. Andrews, William R. Spreen, Hiroshi Mohri, Lee Moss, Susan Ford, Agegnehu Gettie, Kasi Russell-Lodrigue, Rudolf P. Bohm, Cecilia Cheng-Mayer, Zhi Hong, Martin M...

Proceedings of the National Academy of Sciences USA online: March 5, 2014

Proceedings of the National Academy of Sciences USA online: March 5, 2014 Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia Myriam Heiman, Adrian Heilbut,Veronica Francardo, Ruth Kulicke, Robert J.  Fenster, Eric D. Kolaczyk, Jill P. Mesirov, Dalton J. ...

in the news

Injections providing protection against AIDS in monkeys, studies find   "Two studies [one by David Ho, director of the Aaron Diamond AIDS Research Center at Rockefeller University] each found 100 percent protection in monkeys that got monthly injections of antiretroviral drugs, and there was evid...

Proceedings of the National Academy of Sciences USA 111: 3614-3619 (14-3-4)

Proceedings of the National Academy of Sciences USA 111: 3614-3619 Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels Stephen G. Brohawn, Zhenwei Su and Roderick MacKinnon
Awards and Honors

Adjunct faculty member Kayo Inaba receives L'Oréal-UNESCO Women in Science award

Kayo Inaba, known for her work on dendritic cells, is being honored as the Asia-Pacific recipient of the L’Oréal-UNESCO Women in Science award, which supports eminent women in science throughout the world who are working in the life and physical sciences. Inaba is an adjunct faculty member in Mic...
Awards and Honors

Elaine Fuchs receives prestigious award from American Association for Cancer Research

In recognition of her contributions to the understanding of skin, skin stem cells and skin-related disease, Rockefeller’s Elaine Fuchs will receive the 2014 Pezcoller Foundation-AACR International Award for Cancer Research from the American Association for Cancer Research. The award, announced to...

Proceedings of the National Academy of Sciences USA online: March 3, 2014

Proceedings of the National Academy of Sciences USA online: March 3, 2014 microRNAs are biomarkers of oncogenic human papillomavirus infections Xiaohong Wang, Hsu-Kun Wang, Yang Li, Markus Hafner, Nilam Sanjib  Banerjee, Shuang Tang, Daniel Briskin, Craig Meyers, Louise T. Chow, Xing Xie, Thomas ...

Current Biology 24: 494-508 (14-3-3)

Current Biology 24: 494-508 FLRT3 is a robo1-interacting protein that determines netrin-1 attraction in developing axons Eduardo Leyva-Díaz, Daniel del Toro, Maria José Menal, Serafi Cambray, Rafael Susín, Marc Tessier-Lavigne, Rüdiger Klein, Joaquim Egea and Guillermina López-Bendito

Science 343: 1010-1014 (14-2-28)

Science 343: 1010-1014 Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma Joshua N. Honeyman, Elana P. Simon, Nicolas Robine, Rachel Chiaroni-Clarke, David G. Darcy, Irene Isabel P. Lim, Caroline E. Gleason, Jennifer M. Murphy, Brad R. Rosenberg, ...
Science News

Researchers discover unusual genetic mutation linked to adolescent liver cancer

In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center (NYGC), an unusual mutation has been found that is strongly linked to o...

In the news

Teen helps scientists study her own rare disease   "Making that idea work required a lot of help from real scientists: Her father, [Sanford Simon], who runs a cellular biophysics lab at The Rockefeller University; her surgeon at Memorial Sloan-Kettering Cancer Center; and gene specialists at the ...
Science News

Research shows combination of sensory signals draw mosquitoes in for a bite

It may seem like mosquitoes will bite anything with a pulse, but they’re actually quite strategic in picking their victims. A new study from The Rockefeller University looked at the interaction of different sensory cues — carbon dioxide, heat and odor — that attract mosquitoes to humans, and f...
Cell 156: 1060-1071 Multimodal integration of carbon dioxide and other sensory cues drives mosquito attraction to humans Conor J. McMeniman, Román A. Corfas, Benjamin J. Matthews, Scott A. Ritchie and Leslie B. Vosshall

Cell 156: 986-1001 (14-2-27)

Cell 156: 986-1001 Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation Nora Pencheva, Colin G. Buss, Jessica Posada, Taha Merghoub and Sohail F. Tavazoie
Awards and Honors

Sebastian Klinge awarded Sloan Research Fellowship

Rockefeller’s Sebastian Klinge, who joined the faculty in September, will be the recipient of one of the most distinguished awards for early-career scientists from the United States and Canada, the Alfred P. Sloan Research Fellowship. Klinge is among 126 scholars from a range of scientific discip...

Molecular Cell 53: 655-662 (14-2-20)

Molecular Cell 53: 655-662 Replication origin selection regulates the distribution of meiotic recombination Pei-Yun Jenny Wu and Paul Nurse

Proceedings of the National Academy of Sciences USA online: February 18, 2014

Proceedings of the National Academy of Sciences USA online: February 18, 2014 Chemical-biogeographic survey of secondary metabolism in soil Zachary Charlop-Powers, Jeremy G. Owen, Boojala Vijay B. Reddy, Melinda A. Ternei and Sean F. Brady

Proceedings of the National Academy of Sciences USA 111: 2770-2775 (14-2-18)

Proceedings of the National Academy of Sciences USA 111: 2770-2775 Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels Navin Pokala, Qiang Liu, Andrew Gordus and Cornelia I. Bargmann

Current Biology 24: 451-458 (14-2-17)

Current Biology 24: 451-458 The genome of the clonal raider ant Cerapachys biroi Peter R. Oxley, Lu Ji, Ingrid Fetter-Pruneda, Sean K. McKenzie, Cai Li, Haofu Hu, Guojie Zhang and Daniel J.C. Kronauer

Genes and Development 28: 328-341 (14-2-15)

Genes and Development 28: 328-341 SOX9: a stem cell transcriptional regulator of secreted niche signaling factors Meelis Kadaja, Brice E. Keyes, Mingyan Lin, H. Amalia Pasolli, Maria Genander, Lisa Polak, Nicole Stokes, Deyou Zheng and Elaine Fuchs

Cell Host Microbe 15: 190-202 (14-2-12)

Cell Host Microbe 15: 190-202 Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness Timothy Sheahan, Naoko Imanaka, Svetlana Marukian, Marcus Dorner, Peng Liu,  Alexander Ploss and Charles M. Rice

Proceedings of the National Academy of Sciences USA online: February 12, 2014

Proceedings of the National Academy of Sciences USA online: February 12, 2014 Structure of a myosin adaptor complex and pairing by cargo Hang Shi, Nimisha Singh, Filipp Esselborn and Günter Blobel

Nature online: February 9, 2014

Nature online: February 9, 2014 L-Myc expression by dendritic cells is required for optimal T-cell priming Wumesh KC, Ansuman T. Satpathy, Aaron S. Rapaport, Carlos G.  Briseño, Xiaodi Wu, Jörn C. Albring, Emilie V. Russler-Germain, Nicole M. Kretzer, Vivek Durai, Stephen P. Persaud, Brian T. Ede...
Science News

Psoriasis researchers identify molecular changes responsible for skin discoloration

Itchy, painful rashes — such as those that occur with psoriasis — are uncomfortable, but at least they fade when the flare-up subsides. Mostly. Evidence often remains in the form of dark, discolored areas of skin, serving as a reminder of the disease. A new study supported by the Milstein Medica...

Neuron 81: 616-628 (2-5-14)

Neuron 81: 616-628 Temporal responses of C. elegans chemosensory neurons are preserved in behavioral dynamics Saul Kato, Yifan Xu, Christine E. Cho, L.F. Abbott and Cornelia I. Bargmann

Proceedings of the National Academy of Sciences USA 111: E537-545 (14-2-4)

Proceedings of the National Academy of Sciences USA 111: E537-545 Hydrodynamics and collective behavior of the tethered bacterium Thiovulum majus Alexander Petroff and Albert Libchaber

Journal of Clinical Investigation 124: 725-729 (2-3-14)

Journal of Clinical Investigation 124: 725-729 Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity Stylianos Bournazos, Siu-Kei Chow, Nareen Abboud, Arturo Casadevall and Jeffrey V. Ravetch
Campus News

Announcements

Registration to be required for bicycles. In an effort to encourage safe bicycle use and eliminate abandoned bikes, the university is implementing a bicycle registration program. Required permits will be issued at the security desk in Founder’s Hall for no charge. Beginning February 3, any bike t...
Campus News

"River Building" is approved by community board

by ZACH VEILLEUX The university’s formal application for city zoning approval to build a 160,000 square foot laboratory building over the FDR Drive has been approved by Community Board 8, a key step in the city’s multi-agency review of the project. The “River Building” proposal grew out ...
Campus News

Tim O’Connor named VP and chief of staff

by ZACH VEILLEUX When Timothy P. O’Connor left his faculty position in the department of genetic medicine at Weill Cornell Medical College in 2009, it was for an opportunity he couldn’t pass up — to be associate provost for science and technology at Yale University. He would be a key part of ...
Campus News

New faculty member studies ribosome structure

by ZACH VEILLEUX Sebastian Klinge, named to Rockefeller’s faculty in June as its newest tenure-track member, is a biochemist and structural biologist interested in understanding the ribosome, the cell’s protein factory. Dr. Klinge’s laboratory, the Laboratory of Protein and Nucleic Acid Chemi...
Campus News

John Tooze, VP of scientific and facility operations, retires

by LESLIE CHURCH John Tooze, known as much for his wry British wit as for the immense role he’s had in shaping the university’s scientific infrastructure over the last eight years, retired from his position as vice president of scientific and facility operations in May 2013. Dr. Tooze leaves a...
Campus News

Events celebrate longtime employee service at Rockefeller

Several ceremonies were held last year to commemorate years of service to the university by Rockefeller employees. In November, 33 members of the university were celebrated for 10 years of service. And in May, an Employee Recognition Reception was held to honor 31 employees who have worked at Roc...
Campus News

New university Board members have backgrounds in medicine and finance

by LESLIE CHURCH The university’s Board of Trustees elected three new members in 2013: Anna Chapman, a psychiatrist in private practice in New York; Elizabeth Rivers Curry, founder and managing director of Eagle Capital Management, an investment firm; and Jonathan M. Nelson, chief executive offi...
Campus News

James Simons honored with Life Trusteeship; Pat Rosenwald voted Emeritus Trustee

by LESLIE CHURCH The Rockefeller Board of Trustees has conferred its highest honor — one that has been given only twice previously — on James Simons, the philanthropist, mathematician and investment manager who has served on the univeristy’s Board since 2000. For his exceptional service to Roc...
Campus News

Psychologist and author Kay Redfield Jamison awarded 2012 Lewis Thomas Prize

by LESLIE CHURCH There has always been a fine line between madness and genius. As a clinical psychologist, Kay Redfield Jamison has been able to examine that line from a scientific perspective; and as a writer, she has shared both her scientific and personal findings on mental illness with the pu...
Campus News

Obituaries

Grant Martin Grant Martin, a research assistant in Paul Greengard’s lab, died unexpectedly at age 26 on July 26. Mr. Martin joined the Greengard lab in 2010 and worked under the supervision of Yong Kim, where he managed the lab’s microscopy facilities. His research interests were in Alzheimer...
Campus News

Milestones

Awarded: Titia de Lange, the 2013 Jill Rose award from the Breast Cancer Research Foundation, in recognition of her fundamental contributions to research on telomeres and their relationship to aging and cancer. The award was presented at the foundation’s annual symposium and awards luncheon in Ne...

Cell 156: 522-536 (January 30, 2014)

Cell 156: 522-536 Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit Todd E. Anthony, Nick Dee, Amy Bernard, Walter Lerchner, Nathaniel Heintz and David J. Anderson
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