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germinalcenters
Science News

How the immune system deals with the gut's plethora of microbes

New research suggests that our immune system may play an active role in shaping the digestive-tract flora, which is tightly linked to health and disease.
actin binding
Science News

How cells use mechanical tension sensors to interact with their environment

In a painstaking experiment, scientists suspended a single protein filament between two microscopic beads. Their results have shed light on an elusive process in which cells receive and respond to mechanical cues.
Manish Ponda photo
Science News

Rockefeller issues license for the development of novel anti-inflammatory drug

The novel compound, discovered in Jan L. Breslow’s lab and now licensed to Bridge Medicines, will be designed to treat immune-mediated diseases without harming the rest of the immune system.
Blood taste neurons
Science News

Scientists discover mosquitoes’ unique blood-taste detectors

Female mosquitoes are armed with syringe-like stylets that begin to pump furiously only in the presence of blood. Scientists are now studying the specific neurons that line the stylet, and asking what mosquitoes taste when they bite us.
A mouse lung with metastases
Science News

Cancer cells use nerve-cell tricks to spread from one organ to the next

New research suggests that breast and lung tumors metastasize by hijacking a neural signaling pathway, potentially opening the door to better diagnostics and treatments.
Genetically diverse mice
Science News

A revised map of where working memory resides in the brain

Findings from genetically diverse mice challenge long-held assumptions about how the brain is able to briefly hold onto important information.
Image from Casanova lab
Science News

Scientists trace severe COVID-19 to faulty genes and autoimmune condition

The findings explain why some people are so vulnerable to the infection, and suggest new avenues for treatment.
Science News
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In Brief

How dividing cells avoid setting off false virus alarms

A new molecular structure explains how cells hold an alarm-triggering protein captive during cell division, preventing cells from targeting their own DNA.
A cross section of the colon with enteric neurons highlighted
Science News

Microbes in the gut may influence metabolism

A growing number of studies find that microbes in the gut directly influence biological processes from bowel movements to behavior. New research reveals how they impact levels of glucose in the blood.
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In Brief

Scientists uncover antiviral protein that blocks coronavirus infection

New research identifies a protein that blocks infection by SARS-CoV-2, the coronavirus that causes COVID-19, along with several other types. The findings could inform treatment strategies and help us better prepare for future outbreaks.
Epidermal stem cells
Science News

How mechanical forces nudge tumors toward malignancy

Researchers studying two forms of skin cancer identified a long-overlooked factor determining why some tumors are more likely to metastasize than others: the physical properties of the tissue in which the cancer originates. The findings might set the stage for new ways to monitor and treat the di...
Science News
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In Brief

Newly discovered anti-CRISPR protein gives viruses a leg up against bacteria

Molecular CRISPR-Cas systems, most commonly known for their usefulness as gene editing tools, are ancient defense mechanisms employed by bacteria against viruses. The discovery of a counteracting viral trick could inform scientists' efforts to develop future gene-editing technologies.
Mouse cortical neurons
Science News

Study uncovers the molecular events by which popular antidepressants work

Scientists have outlined a molecular program by which serotonin reuptake inhibitors reshape the brain to alleviate depression. Their findings provide clues for how to make better and faster-acting versions of these drugs.
coronavirus-escape-study-Bieniasz
Science News

Will SARS-CoV-2 escape future drugs by mutating? The answer may be a nuanced “no.”

Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potent...

Structural basis for helicase-polymerase coupling in SARS-CoV-2
Science News

A never-before-seen image of the coronavirus copy machine

The high-resolution 3D image can speed COVID-19 drug discovery.
A neutralizing antibody blocks the entry of a surrogate virus
Science News

How toothless mock viruses could advance research on COVID-19

Scientists have engineered four viruses resembling SARS-CoV-2 to enable faster and safer research on vaccines and treatments.
Microbiota-sympathetic-neurons
Science News

Bacteria in the gut have a direct line to the brain

Scientists find that microbes inside the intestines can control the activities of neurons connecting the gut and brain.
The helicase of the Hepatitis C virus.
Science News

Amid the rush for COVID-19 drugs, a case for the helicase

The enzyme is essential for the virus to replicate itself inside our cells. Scientists already have ideas for how to block it.
sympathetic innervation of adipose tissue
Science News

How neurons in body fat grow to boost calorie-burning capacity

Scientists have found that a hormone tells the brain to dramatically restructure neurons embedded in fat tissue.  Their work widens our understanding of how the body regulates its energy consumption, and how obesity might be treated in the future.
Blood droplet
Science News

Novel cells might act as a warning sign for rheumatoid arthritis flares

A genomics study has identified a previously unknown cell type whose blood levels tend to rise and fall in patients with rheumatoid arthritis. The findings could make it easier to manage the disease and help scientists understand its root causes.
Memory-forming neurons (green) in the brain
Science News

Why memory-forming neurons are vulnerable to Alzheimer's

Scientists have used advanced technology to “micro-dissect” the first brain cells to perish in Alzheimer’s disease. The result is a short list of genes that could represent new drug targets.
SARS-CoV-2 neutralizing antibodies
Science News

COVID-19 immunology study reveals universally effective antibodies

New findings characterize human antibody response to SARS-Cov-2, with implications for convalescent plasma therapy, vaccine design, and antibody-based drugs.

Hair cells in zebrafish organ
Science News

Transparent fish reveal the subtle, cellular dance in which sensory organs take shape

How do primitive cells “know” where to go during development? Scientists studying the fish equivalent of inner-ear hair cells have shown that biochemical and mechanical cues work together to orchestrate a highly complex arrangement.
llamas participating in research
Science News

How antibodies from llamas may lead to COVID-19 treatment

Llamas make antibodies that are much smaller than their human counterparts, yet still potent. Scientists hope that future drugs based on these molecules could provide new weapons against SARS-CoV-2.
Withdapi image
Science News

Brain study finds a molecular “off” switch for nicotine craving

In findings that might lead to better smoking-cessation tools, scientists have shown that manipulating a specific brain receptor can alter a mouse’s nicotine sensitivity.
BRCA2 mutation
Science News

Unique mutation reveals a new role for well-known DNA-repair gene

The discovery of a rare mutation in BRCA2, commonly known as the breast cancer gene, has shed new light on how cells safeguard their genetic material.
 
Immune cell clusters
Science News

Study reveals first evidence inherited genetics can drive cancer’s spread

Scientists have long struggled to understand what drives a tumor to seed itself elsewhere in the body. New research implicates our own pre-existing genetics.
Kawasaki disease
Science News

Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19

The condition resembles a rare childhood illness, Kawasaki disease. Researchers are analyzing blood samples to find genetic clues to what might be causing it.
NFI post wound
Science News

Mice with patchy coats lay bare how stem cells endure

Scientists have discovered how stem cells in the skin maintain their ability to replenish themselves, a process critical for hair growth. The findings suggest that errors in stem cell maintenance might contribute to permanent hair-loss conditions.
DNA code on screen
Science News

The gene hunt to explain why some young, healthy people die from COVID-19

People under 50 without preexisting conditions typically develop mild symptoms of coronavirus infection—but there are exceptions. Researchers are working to identify rare genetic variations that may explain why some in this group have succumbed to the disease.
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