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Year in review: 10 science stories to remember

Rockefeller researchers accomplished a lot this year. We look back at 10 of the most exciting science stories of 2018.

Study explains how geckos gracefully gallop on water

Geckos are amazingly agile. In addition to running across land and up trees, the animals can prance across the surface of water. A new study reveals how they do it.

Shape-shifting protein protects bacteria from invaders

Researchers have discovered how bacteria manage to destroy enemy DNA, while keeping their own genetic material safe.

First mapping of cells in the early human placenta to advance research on problem pregnancies

Scientists have made the first comprehensive inventory of cells present in the human placenta of the first trimester, a stage when many pregnancy complications are thought to arise. The findings could fuel new research on conditions such as preeclampsia and pre-term birth.

New method for studying gene expression could improve understanding of brain disease

By analyzing gene expression patterns, researchers have identified previously unknown distinctions between mouse and human neurons. They have also developed a new way to track cellular changes associated with brain disorders.

Mosquito genome opens new avenues for reducing bug-borne disease

Researchers have assembled a new and improved DNA catalogue for the mosquito Aedes aegypti. This tool will help researchers understand the insect’s biology, and may lead to new strategies for preventing diseases like Zika and dengue.

Embryos remember the chemicals that they encounter

A new study shows that embryonic cells retain a memory of the chemical signals to which they are exposed. Without these memories, cells fail organize into distinct tissue types.

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Enzyme structure helps to explain how protein factories are constructed

Researchers characterized the structure of Mdn1, an enzyme key to making ribosomes.

Searching in soil, scientists find a new way to combat tuberculosis

Analyzing soil samples from across the country, researchers have identified an antibiotic capable of treating strains of tuberculosis that do not respond to existing therapies.

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New approach to cancer immunotherapy overcomes toxicity hurdle

Using a unique mouse model, Rockefeller scientists have developed a new strategy in cancer immunotherapy that is more safe and effective than other treatments of its kind.

To see what’s right in front of you, your brain may need some rewiring

As you encounter new experiences and form new memories, your brain changes. Now, researchers show that some of these change occur in a brain region devoted to visual perception.

In tiny worms, researchers find spiking neurons—and clues about brain computation

Studying neurons in C. elegans, researchers made a surprising discovery: these roundworms, like most animals, process information using a digital, electric code.

Scientists investigate how DEET confuses countless critters

DEET, a chemical in bug sprays, affects the behavior of highly diverse organisms—but how it works remains unclear. New research in C. elegans shows that the compound exploits unique receptors and neurons to interfere with the animals’ response to odors.

In clinical trials, new antibody therapy controls HIV for months after treatment

A new clinical trial shows that broadly neutralizing antibodies can suppress HIV for up to four months, far longer than currently available drugs.

Study of protein “trafficker” provides insight into autism and other brain disorders

Researchers have discovered that the protein ASTN2 shuttles receptors away from the surface of neurons, a process that facilitates efficient brain activity.

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New gene-engineering technique will help scientists study the immune system

Using gene editing technology, researchers have developed a new way to study B cell activation in mice. This technique makes research more efficient, and has the potential to improve our understanding of immune responses in humans.

Ant-y social: study of clonal raider ants reveals the evolutionary benefits of group living

A new study in ants demonstrates that living in groups leads to improved fitness. The researchers show that, in larger groups, ants take on specialized roles and colony stability increases.

Structure of ion channel reveals how insects smell their way around the world

Researchers describe, for the first time, the structure of a smell-receptor protein common among insects. Its inner architecture illuminates how insects evolved to detect an amazing diversity of odors.

Researchers uncover molecular mechanisms of rare skin disease

Scientists describe a group of proteins that protect cells from a subtype of human papilloma virus. They also outline genetic mutations that make this virus unusually harmful in people with epidermodysplasia verruciformis, a rare skin condition.

Lack of a single molecule may indicate severe and treatment-resistant depression

Researchers find that a deficiency of acetyl-L-carnitine is associated with a particular subtype of depression. Individuals with very low levels of this molecule often have highly severe symptoms and don’t respond to traditional antidepressants.

Ant study sheds light on the evolution of workers and queens

A new study in ants identifies a peptide that plays an important role in regulating reproduction. This research illuminates a potential trajectory for the evolution of distinct social castes—workers and queens.

Giant neurons in the brain may play similarly giant role in awareness and cognition

Scientists find that certain neurons release nitric oxide onto nearby blood vessels, and potentially use this mechanism to control awareness in the brain.

Studies reveal possible origin of human speech

Scientists have long debated the evolutionary origins of human speech. New research reveals neural circuits in the brains of monkeys that may represent the source of our unique speech capabilities.

Scientists discover a mechanism of drug resistance in breast and ovarian cancer

A new study helps explain why certain cancers don't respond to treatment, and offers hope for overcoming this deadly resistance.

Deep in the fly brain, a clue to how evolution changes minds

A new study sheds light on the mysterious ways in which evolution may tweak the brain to shape behavior. It started with a close look at two Drosophila species and their mating maneuvers.

A new tactic for starving tumors

Scientists have found a metabolic particularity in tumor cells lacking oxygen. The discovery might point to new drugs to target the most difficult-to-treat spots within a tumor.

Scientists solve the case of the missing subplate, with wide implications for brain science

A new study shows that a group of neurons, previously thought to die in the course of development, in fact become incorporated into the brain’s cortex. This research has implications for understanding—and possibly treating—several brain disorders.

Troves from a search for new biomarkers: blood-borne RNA

Scientists have found a new way to trawl blood samples for snippets of RNA released by tumors or diseased organs. The method might eventually help doctors diagnose and track a wide range of medical conditions.

Drowsy worms offer new insights into the neuroscience of sleep

Scientists studying worms have discovered a group of cells that help the body transition from wakefulness to slumber.

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Genetic mutation identified as culprit in rare infectious disease

Researchers have uncovered the genetic factors that make some people susceptible to Whipple's disease, an intestinal inflammatory disorder that causes diarrhea, pain, and weight loss.