Skip to main content
Displaying 1171 of 2857 articles.

Unlocking how the new Alzheimer’s drug lecanemab works

As with many cutting-edge therapies, we know more about the drug's effectiveness than we do about how it actually operates. A new study reveals a possible mechanism for its impact on patients.

>

Boosters are key to protecting pregnant individuals and newborns against the worst effects of COVID

Patients with a specific cocktail of COVID exposure had the highest level of antibodies against SARS-CoV-2 and its variants, which also provided a strong immunological shield for their babies.

Researchers find an epigenetic key that unlocks common deadly cancers

In skin, some aberrant adult epidermal stem cells turn on SOX9, kickstarting a process that ultimately activates cancer genes.

An immune flaw may cause West Nile virus’s deadliest symptoms

With 40% of encephalitis cases now explained by an autoimmune deficiency, West Nile virus "is by far the best understood human infectious disease in the world. It’s stunning.”

How one of nature's most fundamental molecules forms

New high-resolution images of the large ribosomal subunit shed light on how human ribosomes are assembled.

Researchers discover neuronal mechanism linked to a minutes-long decision process in fruit flies

They identified a brain signal that guides one type of decision-making—findings that could build a foundation for understanding how humans make educated and strategic decisions.

The potential molecular indicators of Parkinson’s symptoms

Overlapping RNA changes in the blood and brain were associated with many of the clinical signs of the disease.

Proteome of rare liver cancer sheds new light on basic biology

Fibrolamellar carcinoma not only hinders the body's ammonia consumption but also produces ammonia, a finding with sweeping implications for treating this cancer—and the study of ammonia metabolism.

World’s first transgenic ants reveal how colonies respond to an alarm

The findings raise tantalizing possibilities for revealing what hundreds of ant odorant receptors are up to.

>

New algorithm cleans microbiome data with unprecedented efficiency

The algorithm, dubbed SCRuB, can distinguish native bacteria and viruses from contaminants—a powerful tool for researchers working with the microbiome.

Lab-grown mini lungs could accelerate the study of respiratory diseases  

The labs of Ali Brivanlou and Charles M. Rice collaborated to refine a cell culture technology platform that grows genetically identical lung buds from human embryonic stem cells.

The clearest snapshot of human genomic diversity ever taken

The human reference genome has always been a remarkable but flawed tool. A new "pangenome" aims to correct its oversights and omissions.

Behind the formation and protection of microtubules

Research shed light on the process by which the γ-Tubulin Ring Complex stabilizes microtubules, which may inform the study of developmental diseases and cancers.

Solving the mystery behind how nutrients enter cells

A new paper describes how choline is transported into the cell, with potentially sweeping implications for the study of rare diseases.

Researchers reveal an ancient mechanism for wound repair

The study is the first to identify a damage response pathway that is distinct from but parallel to the classical pathway triggered by pathogens.

Gum disease may lie at the root of some arthritis flare-ups

Damaged gums may release bacteria into the bloodstream that trigger arthritis flare-ups, potentially explaining why people with gum disease don't respond as well to arthritis treatments.

New tool to study hepatitis B could open the door to a cure

Just as the Rice lab’s work on HCV exposed that virus’s weaknesses, the hope is that this novel approach could do the same for HBV.

Scientists discover brain region linking short-term to long-term memory

The anterior thalamus plays such a key role in memory that boosting it in mice consolidates the animals' trivial experiences into long-term memories.

>

New technique captures unprecedented view of the active brain

The tech, dubbed MesoLF, captures 10,500 neurons buried at once-inaccessible depths, firing from brain regions many millimeters apart, simultaneously—all with unprecedented resolution.

Innovative approach opens the door to COVID nanobody therapies

The relatively simple and low-cost procedure could empower laboratories in low-resource areas to generate nanobodies against SARS-CoV-2, as well as other viruses.

Illuminating the evolution of social parasite ants

The findings offer a new way to understand how some ants become total layabouts.

Homing in on the genetics of severe COVID in children

A trio of faulty genes fail to put the brakes on the immune system’s all-out assault on SARS-CoV-2, leading to the inflammatory overload characteristic of MIS-C.

The nutrient that cancer cells crave

Starving cancer cells of a key amino acid could potentially render tumors more vulnerable to the body’s natural immune response.

A unique window into "original antigenic sin"

The body's first blush with a pathogen shapes how it will respond to vaccines. New evidence clarifies how this phenomenon works, mechanistically.

How the body's B cell academy ensures a diverse immune response

A diverse immune response hinges on naive B cells mingling with high affinity ones in the late-stage germinal center. Whether that helps or hinders, however, depends on the virus.

Why older fathers pass on more genetic mutations to their offspring

It's not just the number of mutations that matters. It's the failure to fix them too.

>

Solving a crucial bottleneck in drug discovery

A novel method reduces the time required to identify novel antibiotic-producing DNA from weeks to days.

When the body's B cell training grounds stay open after hours

While most germinal centers shut down after a few weeks, some stay in business for more than six months. A new study helps explain why.

Intriguing science discoveries of 2022

Breakthroughs in genetics, biochemistry, neuroscience, infectious disease, and drug development were a few of the year's highlights.

>

How a cell's mitochondria make their own protein factories

The findings shed a rare light on mitoribosomes, the unique ribosomes found within the cell's mitochondria.