Two techniques—one for optics-free spatial mapping of tissue organization and the other for the enrichment of rare cell types—offer new ways to study aging and disease.
RNA polymerase, the enzyme that synthesizes RNA from DNA during transcription, has been captured mid-reaction for the first time. The findings provide a universal blueprint for gene expression.
The findings, which have implications for cancer and other diseases, resulted from capturing the first snapshot of a mechanical signaling complex in action.
By editing blood stem cells, researchers show that the immune system itself can be transformed into a durable, boostable source of therapeutic proteins—opening the door to novel treatments
