By focusing on the emergent features of cell collectives, instead of individual cells, scientists forge a new path for understanding how organs develop their architecture.
The labs of Ali Brivanlou and Charles M. Rice collaborated to refine a cell culture technology platform that grows genetically identical lung buds from human embryonic stem cells.
A new study suggests that stem cells are able to integrate cues from their surroundings and coordinate their behavior across tissue through networks of vasculature in their close vicinity.
In developing bird skin, immature cells move around and form intricate patterns. Scientists are zeroing in on the mechanical forces guiding the process.
Epidermal stem cells that hail from the hair follicle retain memories of their journey to the skin's surface. Those memories are a boon for wound repair, but may also contribute to chronic diseases and cancer.
New research casts doubt on a genetic test used to screen would-be embryos for IVF implantation. The findings suggests that these embryos can develop into healthy babies regardless of whether or not they’ve been flagged as defective by the test.
Cohen, a physician-scientist exploring obesity and metabolic disease, has conducted groundbreaking research on the complex inner workings of fat tissue.
Scientists have developed stem-cell technology to mass-produce tissue cultures resembling our breathing organs. These tissues offer a powerful model in which to study how SARS-CoV-2 wreaks havoc in the lungs and to screen for new drugs.
COVID-19 causes a host of diverse complications, from lung inflammation to blood clots, heart failure, and brain fog. A team of scientists believes these attributes may have a single culprit—and that findings from research on Alzheimer’s disease might give them a leg up in finding it.
Rice will receive the 2020 Nobel Prize in Physiology or Medicine for research that led to a cure for hepatitis C, a viral disease affecting 170 million people worldwide. His lab worked on the virus for three decades and became the first to produce a version of it that could be grown and studied i...
Researchers studying two forms of skin cancer identified a long-overlooked factor determining why some tumors are more likely to metastasize than others: the physical properties of the tissue in which the cancer originates. The findings might set the stage for new ways to monitor and treat the di...
How do primitive cells “know” where to go during development? Scientists studying the fish equivalent of inner-ear hair cells have shown that biochemical and mechanical cues work together to orchestrate a highly complex arrangement.
Scientists have identified the mechanism that allows skin cells to sense changes in their environment, and very quickly respond to reinforce the skin's outermost layer. The findings provide insight into how errors in this process might lead to skin conditions like psoriasis.
Protein clumps are routinely found in the brains of patients with neurodegenerative diseases. Now researchers find a link between this buildup and the intracellular movement of proteasomes, molecular machines tasked with degrading protein waste inside cells.
Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
To grow new hair, stem cells throughout the skin must work in sync. Researchers have discovered the molecular communication tool, part of the lymphatic system, that the cells use to synchronize their activities.
Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.
Using a new technique to study brain development, scientists were able to trace the causes of Huntington's back to early developmental stages when the brain has only just begun to form.
Researchers have created a new 3D model of human embryonic tissue that promises to shed light on critical components of development—including processes that go awry during pregnancy complications.
Scientists have discovered a curious phenomenon taking place in mouse skin: cells compete with one another for the chance to develop into mature tissue. The findings indicate that this antagonism is key to creating healthy skin.
