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Displaying 159 of 2857 articles.
samice Ixodes
Science News

Brain disease transmitted by tick bites may be treatable

The virus that causes tick-borne encephalitis appears to trick the immune system, misdirecting it into producing inferior antibodies. But new research shows some people produce more potent antibodies, providing hope for treatment.
daniel mucida
Campus News

Immunologist Daniel Mucida promoted to professor

A pioneer in the field of mucosal immunology, Mucida is unlocking the secrets of the digestive system and answering fundamental questions about the origins of human disease.
Science News
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In Brief

How one patient’s rare mutation helped solve a mycobacterial mystery

The discovery may explain why some patients suffer more severe reactions than others—putting us one step closer to understanding how our DNA influences our susceptibility to a wide range of infectious diseases.
Blood donation for COVID-19 research
Science News

Rockefeller grants commercial license for the development of monoclonal antibodies for treatment of COVID-19

The treatment, a combination of two antibodies, has been shown highly capable of neutralizing SARS-CoV-2 in preclinical studies. Researchers hope it will give countries around the world, including developing countries, a way to control the rampant disease.
Injection Vial Production Line
Science News

COVID-19 vaccines may need regular updates for emerging variants

Lab experiments suggest that the new strains reported in Britain, South Africa, and Brazil may blunt the potency of the Pfizer and Moderna COVID-19 vaccines. This could mean that the vaccines will need updates as the virus mutates.
Coronavirus-intenstines-immunofluorescence
Science News

The immune system mounts a lasting defense after recovery from COVID-19

The study participants continued to improve their antibodies months after initial infection, potentially due to exposure to remnants of the virus hidden in the gut.
Monoclonal antibodies
Science News

Rockefeller begins testing of new COVID-19 antibody drug in people

Patients in the clinical trial will receive two highly potent antibodies against SARS-CoV-2 discovered at the university. Designed to prevent people with early COVID-19 from developing severe disease, the treatment is urgently needed as hospitals continue to be inundated by repeated surges of inf...
TMEM41B staining
Science News

Scientists map the network of SARS-CoV-2’s helpers inside human cells

The virus must hijack a more than a hundred human proteins to replicate inside a cell. One of them stands out because it is an absolute requirement for infection by four different coronaviruses as well as by viruses that cause Zika, yellow fever, and other diseases.
germinalcenters
Science News

How the immune system deals with the gut's plethora of microbes

New research suggests that our immune system may play an active role in shaping the digestive-tract flora, which is tightly linked to health and disease.
Charles M. Rice
Awards and Honors

Rockefeller's Charles M. Rice honored with Nobel Prize for research that contributed to a cure for hepatitis C

Rice will receive the 2020 Nobel Prize in Physiology or Medicine for research that led to a cure for hepatitis C, a viral disease affecting 170 million people worldwide. His lab worked on the virus for three decades and became the first to produce a version of it that could be grown and studied i...
Image from Casanova lab
Science News

Scientists trace severe COVID-19 to faulty genes and autoimmune condition

The findings explain why some people are so vulnerable to the infection, and suggest new avenues for treatment.
A cross section of the colon with enteric neurons highlighted
Science News

Microbes in the gut may influence metabolism

A growing number of studies find that microbes in the gut directly influence biological processes from bowel movements to behavior. New research reveals how they impact levels of glucose in the blood.
Science News
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In Brief

Scientists uncover antiviral protein that blocks coronavirus infection

New research identifies a protein that blocks infection by SARS-CoV-2, the coronavirus that causes COVID-19, along with several other types. The findings could inform treatment strategies and help us better prepare for future outbreaks.
Science News
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In Brief

Newly discovered anti-CRISPR protein gives viruses a leg up against bacteria

Molecular CRISPR-Cas systems, most commonly known for their usefulness as gene editing tools, are ancient defense mechanisms employed by bacteria against viruses. The discovery of a counteracting viral trick could inform scientists' efforts to develop future gene-editing technologies.
coronavirus-escape-study-Bieniasz
Science News

Will SARS-CoV-2 escape future drugs by mutating? The answer may be a nuanced “no.”

Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potent...

A neutralizing antibody blocks the entry of a surrogate virus
Science News

How toothless mock viruses could advance research on COVID-19

Scientists have engineered four viruses resembling SARS-CoV-2 to enable faster and safer research on vaccines and treatments.
SARS-CoV-2 neutralizing antibodies
Science News

COVID-19 immunology study reveals universally effective antibodies

New findings characterize human antibody response to SARS-Cov-2, with implications for convalescent plasma therapy, vaccine design, and antibody-based drugs.

llamas participating in research
Science News

How antibodies from llamas may lead to COVID-19 treatment

Llamas make antibodies that are much smaller than their human counterparts, yet still potent. Scientists hope that future drugs based on these molecules could provide new weapons against SARS-CoV-2.
Immune cell clusters
Science News

Study reveals first evidence inherited genetics can drive cancer’s spread

Scientists have long struggled to understand what drives a tumor to seed itself elsewhere in the body. New research implicates our own pre-existing genetics.
Kawasaki disease
Science News

Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19

The condition resembles a rare childhood illness, Kawasaki disease. Researchers are analyzing blood samples to find genetic clues to what might be causing it.
DNA code on screen
Science News

The gene hunt to explain why some young, healthy people die from COVID-19

People under 50 without preexisting conditions typically develop mild symptoms of coronavirus infection—but there are exceptions. Researchers are working to identify rare genetic variations that may explain why some in this group have succumbed to the disease.
Blood donation for COVID-19 research
Science News

Scientists are using ‘elite’ antibodies from COVID-19 survivors to develop potent therapies

Most people infected with the coronavirus are able to fight it off because their immune system produces effective antibodies. Rockefeller scientists are working to turn such antibodies into a drug.

Biosafety Level 3
Science News

Rockefeller scientists launch a broad range of studies into novel coronavirus

Over 130 scientists in 18 labs are conducting research to advance the development of new, urgently needed approaches for the prevention and treatment of COVID-19.
Image of a medicine bottle
Science News

Rockefeller grants commercial license for the development of new HIV drugs

The novel compounds are based on so-called broadly neutralizing antibodies, molecules that make rare people's immune systems capable of fighting HIV. They could potentially yield new treatment and prevention approaches benefitting people around the world, including in developing countries.
Human cell infected by CMV
Science News

Patient with unusually severe infection leads scientists to a rare type of immune deficiency

A rare genetic change may explain why some people die from cytomegalovirus, a stealth pathogen that is often asymptomatic.
Small intestine
Science News

Scientists examine how a gut infection may produce chronic symptoms

For some unlucky people, a bout of intestinal distress like traveler’s diarrhea leads to irritable bowel syndrome. Recent discoveries have given scientists a better idea of how this happens, and potential leads for new treatments.
B cells in germinal centers
Science News

New clues about why a universal flu vaccine is so elusive

To scientists' surprise, the immune system develops its response to each virus variant mostly from scratch, instead of building on what it has already learned.
human papilloma virus
Science News

Study pinpoints rare genetic change that may boost risk of HPV-related illness

The human papilloma virus is usually kept in check by the immune system, but scientists identified a genetic variant that makes some infected children prone to developing warts in the throat.
Kidney cells
Science News

Findings shed new light on why Zika causes birth defects in some pregnancies

Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.
Bacteriophages inject their DNA into bacteria, typically resulting in the bacterium’s demise. CRISPR-Cas systems defend bacteria against these attacks.
Science News

To curb infection, bacteria direct their defenses against themselves

To fight off invading viruses, bacteria have evolved a slew of creative defense tactics. New research shows that in some cases, microbes go to great lengths to keep an infection from spreading, even destroying bits of their own genetic material.
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