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Updates on the University COVID-19 response and operations available here.
Displaying 153 of 2775 articles.

Homing in on the genetics of severe COVID in children

A trio of faulty genes fail to put the brakes on the immune system’s all-out assault on SARS-CoV-2, leading to the inflammatory overload characteristic of MIS-C.

Colorectal cancer tumors both helped and hindered by T cells

Researchers have long disagreed over whether 𝛄𝛅T cells in the gut promote or discourage tumor growth, but new evidence suggests they have the capacity to do both.

A third vaccine dose may increase protection from Omicron

The booster appears to galvanize memory B cells into producing potent and versatile antibodies that neutralize both the original virus and its many variants.

Hundreds of new drug targets to combat tuberculosis

The study highlights genes that, when silenced, render Mycobacterium tuberculosis vulnerable to antibiotics, and identifies existing drugs that may be effective against one prominent strain.

A synthetic antibiotic may help turn the tide against drug-resistant bacteria

The compound attacks MRSA, C. diff, and several other deadly pathogens. Its discovery demonstrates the power of combining computational biology, genetic sequencing, and synthetic chemistry to study bacterial evolution.

The genetic underpinnings of severe staph infections

A mutated gene may explain why some Staphylococcus aureus infections turn lethal, a finding with significant implications for people living with 5p- syndrome.

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Antibody therapy controls HIV for months in new clinical trial

Unlike conventional antiretroviral drugs, treatment with broadly neutralizing antibodies does not rely on vigilant daily dosing and could potentially reduce the body’s reservoir of latent viruses.

How bacteria "self-vaccinate" against viral invaders

In studying how bacteria respond to viral infection, scientists are learning that their defense strategies cooperate in ways reminiscent of the elaborate immune systems of animals.

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New comprehensive map of the portal to the cell’s nucleus

The findings, which may have implications for a wide range of human diseases, suggest that nuclear pore complexes vary in structure and function even within a single nucleus.

A novel compound might defeat multidrug-resistant bacteria common in hospitals

Increasingly, hospitalized patients contract infections that evade current antibiotics including colistin, long used as a last treatment option. The discovery of a new colistin variant might make it possible to outmaneuver these pathogens.
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