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The rockefeller university

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Displaying 180 of 2934 articles.
Jeffrey M. Friedman to receive 2020 Breakthrough Prize in Life Sciences
Friedman's discovery of the hormone leptin has transformed our understanding of obesity.
Findings shed new light on why Zika causes birth defects in some pregnancies
Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.
Fruit flies find their way by setting navigational goals
Navigating fruit flies do not have the luxury of GPS, but they do have a kind of neural compass. In a new study, researchers found that the animals decide which way to turn by comparing this internal compass needle to a fixed goal.
New molecular diagnostics test could help guide lupus treatments
A tool that detects glitches in gene expression could help doctors tailor treatments for lupus-related kidney damage.
To curb infection, bacteria direct their defenses against themselves
To fight off invading viruses, bacteria have evolved a slew of creative defense tactics. New research shows that in some cases, microbes go to great lengths to keep an infection from spreading, even destroying bits of their own genetic material.
New compounds could be used to treat autoimmune disorders
In autoimmune disorders, the body’s defense system erroneously attacks normal cells, leading to serious health problems. Researchers have developed new molecules that potentially could be used to treat many of these conditions.
Cellular rivalry promotes healthy skin development
Scientists have discovered a curious phenomenon taking place in mouse skin: cells compete with one another for the chance to develop into mature tissue. The findings indicate that this antagonism is key to creating healthy skin.
Research on repetitive worm behavior may have implications for understanding human disease
Studying microscopic worms, Rockefeller scientists have identified a brain circuit that drives repetitive behavior—providing potential clues for understanding some human psychiatric conditions.
Study pinpoints what causes relapse after cancer immunotherapy
In many cancer patients who have been treated with immunotherapy, the tumor comes back. New research identifies the cells responsible for thwarting the treatment and offers new insights into how they do it.
New hope for treating a childhood brain cancer
Recent research has shown that a drug known as MI-2 can kill cells that cause a fatal brain cancer. But only now have scientists been able to explain how the compound works: by targeting cholesterol production in tumors.
New approach to treating gastrointestinal disease patches up leaky intestines
Researchers have discovered a new compound that helps fortify the intestine's inner lining, which becomes porous in inflammatory bowel diseases.  
Researchers discover a common link among diverse cancer types
Some cancers have been traced to changes in histones, proteins responsible for packaging DNA and regulating genes. Now, research from Rockefeller scientists shows that, among tumors, mutations to these proteins are a lot more common than previously suspected.
Scientists find new clues about how the body stores fat
Scientists discovered a protein that plays a crucial role in regulating fatty acids, the molecules that make up body fat. This research could lead to new options for treating people with diseases associated with fatty acid buildup.
Researchers discover a weakness in a rare cancer that could be exploited with drugs
Researchers have identified a rare type of cancer cell that cannot make cholesterol, a key nutrient. By targeting this deficiency, scientists may be able to develop new strategies for treating the disease.
Jeffrey M. Friedman to receive the 2019 Wolf Prize in Medicine
Friedman receives the award for his discovery of leptin, a hormone that modulates food intake and energy expenditure.
Study explains how geckos gracefully gallop on water
Geckos are amazingly agile. In addition to running across land and up trees, the animals can prance across the surface of water. A new study reveals how they do it.
Shape-shifting protein protects bacteria from invaders
Researchers have discovered how bacteria manage to destroy enemy DNA, while keeping their own genetic material safe.
First mapping of cells in the early human placenta to advance research on problem pregnancies
Scientists have made the first comprehensive inventory of cells present in the human placenta of the first trimester, a stage when many pregnancy complications are thought to arise. The findings could fuel new research on conditions such as preeclampsia and pre-term birth.
New method for studying gene expression could improve understanding of brain disease
By analyzing gene expression patterns, researchers have identified previously unknown distinctions between mouse and human neurons. They have also developed a new way to track cellular changes associated with brain disorders.
Enzyme structure helps to explain how protein factories are constructed
Researchers characterized the structure of Mdn1, an enzyme key to making ribosomes.
Gaby Maimon and Luciano Marraffini are named HHMI investigators
Maimon, who studies cognition and decision-making, and Marraffini, who studies the bacterial defense system CRISPR-Cas, are among 19 scientists nationwide to receive this designation.
What happens to a dying cell’s corpse? New findings illuminate an old problem
Scientists have discovered a curious way for cells to die. In studying it, they are learning about how remnants of diseased cells are normally chewed up and removed.
Scientists map the portal to the cell’s nucleus
The gateway to cellular headquarters has 552 components. A new map that shows how all these pieces fit together could help scientists study numerous diseases.
Scientists caution that a rare childhood liver cancer can spread to the brain
A new report details three cases of secondary brain tumors in people with fibrolamellar hepatocellular carcinoma. The researchers say imaging tests could improve treatment for patients whose cancer spreads to the brain from the liver.
In brief: Tweaking RNA protects cells from harmful inflammation
New research has helped explain what goes wrong in Aicardi-Goutières syndrome, a rare brain disorder. Patients with the disease have genetic abnormalities that may put their cells at risk of accidentally triggering an antiviral response.
Günter Blobel, a Nobel laureate who redefined cell biology, has died
Günter Blobel, a Nobel Prize-winning Rockefeller biologist who discovered the mechanisms by which proteins are targeted for delivery to specific locations within cells, died February 18 at 81.
In brief: New molecular insights on a rare immune disorder
After figuring out the functions of two proteins involved in the rare genetic condition ICF, scientists pieced together the molecular process that is altered in the disease.
In brief: How the immune system curbs its own mistakes
Researchers discovered how apoptosis keeps potential cancer-causing mutations in check.
3D imaging of fat reveals potential targets for new obesity treatments
With new imaging methods, scientists hope to make significant progress in the fight against obesity. A new report reveals striking images of neural projections within fat tissue, and clues for the development of new drugs.
In brief: New clues about how cells restart stalled replication
Scientists studying the cell’s DNA-copying machinery have discovered a molecular mechanism that helps reactivate it should it stop prematurely. Its function may prevent genetic errors like those that cause cancer.
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