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Displaying 163 of 2812 articles.
Hair follicle micro-niche
Science News

A cell’s destiny is set earlier than expected

Stem cells in the hair follicle are organized by the cell type they will eventually become in unique compartments, at the ready to regenerate tissue.
C. David Allis
Awards and Honors

C. David Allis wins 2017 March of Dimes Prize in Developmental Biology

Allis has received the March of Dimes Prize in Developmental Biology. The award, given to investigators whose research offers hope for the prevention and treatment of birth defects and other infant diseases, honors Allis for his groundbreaking work on gene regulation.
zika envelop protein domain structure
Science News

Discovery of a Zika antibody offers hope for a vaccine

Searching for a way to thwart Zika, scientists have discovered an antibody with a potent ability to neutralize the virus.
squamous carcinoma cells
Science News

A mechanism shared by healing wounds and growing tumors

Scientists have long seen parallels between healing wounds and growing tumors. In studying the molecular changes that occur within both, a research team has discovered a new cancer-fuelling mechanism that potentially could inform drug development.
Tuschl_Nature

Shooting the messenger: how one protein allows germ cells to develop

Researchers have identified a molecule that guides the formation of eggs and sperm by preventing a host of factors related to cell death and inflammation from killing the precursors to these cells. Their findings reveal new knowledge about how a mutation in this molecule leads to male sterility.
Bieniasz_ancient-virus_nw
Science News

Viral fossils reveal how our ancestors eliminated an ancient infection

Some viruses can insert their genetic material into the genome of their host, creating a genetic fossil record. Researchers have uncovered how our ancestors may have wiped out one such virus around 11 million years ago.
Funabiki_scrambled-centromeres_nw
Science News

Scientists discover how crucial DNA sequences endure

The centromere region of chromosomes retains the same DNA from one generation to the next. Scientists have gained new insights into how it avoids being scrambled in normal cells, and how it becomes unstable in cancer.
People who self-describe as night owls often have a sleep disorder encoded in their genes. (Illustration by Jasu Hu)
Science News

Study identifies “night owl” gene variant

Scientists have discovered a common mutation that might explain why some people have trouble going to sleep at night and getting up early. The gene alteration slows the internal biological clock that regulates our sleeping patterns.
Enterobacteria phage T2
Science News

For microbes fighting viruses, a fast response means a better defense

Researchers have found that the bacterial immune system targets an invading virus as soon as it enters the cell. This discovery answers a long-standing question about how microbes defend themselves.
Immobilized worm
Science News

For biologists studying tiny worms, new technologies make big improvements

Two new technologies are helping scientists understand new aspects of organ and nervous system development in C. elegans. One allows them to image worms developing in a natural environment, while the other makes it possible to track single neurons as the worms grow.
Science News

Early intervention with new treatment provides durable control of HIV-like virus in monkeys

There are more than 25 drugs to control HIV, yet the virus remains one of the world’s biggest health problems. One of the many challenges with existing therapies is that a dormant version of the virus is always lurking in the background, ready to attack the immune system as soon as treatment is i...
Science News

A new way to reset gene expression in cancer cells shows promise for leukemia treatment

New findings from Rockefeller University researchers could guide the development of potent combination therapies that deliver more effective and durable treatment of leukemia. In recent work published in Nature, they show it’s possible to deactivate cellular programs involved in tumor growth by d...
Science News

Scientists discover an unexpected influence on dividing stem cells’ fate

When most cells divide, they simply make more of themselves. But stem cells, which are responsible for repairing or making new tissue, have a choice: They can generate more stem cells or differentiate into skin cells, liver cells, or virtually any of the body’s specialized cell types. As r...
Awards and Honors

Howard C. Hang receives 2017 Eli Lilly Award in Biological Chemistry

Howard C. Hang, Richard E. Salomon Family Associate Professor and head of the Laboratory of Chemical Biology and Microbial Pathogenesis, has won the 2017 Eli Lilly Award in Biological Chemistry. The prize, given by the American Chemical Society, recognizes outstanding research in biological chemi...
Science News

Encouraging clinical results for an antibody drug to prevent or treat HIV

A new biologic agent—the most potent of its kind so far—is showing early promise as part of a potential new strategy for treating HIV. The drug, known as 10-1074, may also offer a new way to prevent viral infection in people who are at high risk to acquire HIV, the virus that causes AIDS. ...
The structure unveiled that part of the helicase known as the N-tier travels ahead of the C-tier along the leading DNA strand
Science News

Study reveals the structure of a protein crucial for DNA replication

Our DNA contains instructions crucial for virtually all forms of life on this planet. But for life to propagate, this blueprint must be copied and passed on to future generations. New findings describing the structure of a key molecule involved in DNA replication place another piece in the puzzle...
Science News

Researchers explore how protein production gets distorted in skin cancer

Each cell in the body follows a strict protocol for manufacturing the proteins it needs to function. When a cell turns cancerous, however, its protein production goes off script. A new study led by researchers at the Rockefeller University takes a close look at one way in which this procedure goe...
Science News

Antibody combination puts HIV on the ropes

Without antiretroviral drug treatment, the majority of people infected with HIV ultimately develop AIDS, as the virus changes and evolves beyond the body’s ability to control it. But a small group of infected individuals—called elite controllers—possess immune systems capable of defeating the ...
Awards and Honors

Elaine Fuchs wins 2017 McEwen Award for Innovation

Elaine Fuchs, Rebecca C. Lancefield Professor and head of the Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, has been honored with the 2017 McEwen Award for Innovation. The prize, given by the International Society for Stem Cell Research, recognizes groundbreaking wo...
Science News

New research offers clues into how the brain shapes perception to control behavior

What you see is not always what you get. And that, researchers at The Rockefeller University have discovered, is a good thing. “Every time you move your eye, the whole world moves on your retina,” says Gaby Maimon, head of the Laboratory of Integrative Brain Function. “But you don’t perce...
Science News

Scientists learn how to ramp up microbes’ ability to make memories

Some microbes can form memories—although, inconveniently for scientists who study the process, they don’t do it very often. Rockefeller University researchers and their colleagues at the University of California, Berkeley, have found a way to make bacteria encode memories much more frequently...
Science News

Research on sweat glands suggests a route to better skin grafts

As early humans shed the hairy coats of their closest evolutionary ancestors, they also gained a distinct feature that would prove critical to their success: a type of sweat gland that allows the body to cool down quickly. Those tiny glands are enormously useful, allowing us to live in a wide var...
Campus News

Pels Family Center for Biochemistry and Structural Biology receives new $10 million grant

by Alexandra MacWade, assistant editor A new $10 million endowment gift made by the Donald A. Pels Charitable Trust will provide ongoing support for the university’s chemical and structural biologists through the Pels Family Center for Biochemistry and Structural Biology. Mr. Pels, who was a Roc...
Awards and Honors

Elaine Fuchs to receive 2016 Vanderbilt Prize in Biomedical Science

Elaine Fuchs, Rebecca C. Lancefield Professor and head of the Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, has won the 2016 Vanderbilt Prize in Biomedical Science for her innovative use of reverse genetics to understand skin diseases and cancer stem cells. The priz...
Science News

New research clarifies why wounds heal more slowly with age

Older bodies need longer to mend. This reality of aging has been documented since World War I, with the observation that wounds heal slower in older soldiers. Yet until now, researchers have not been able to tease out what age-related changes hinder the body’s ability to repair itself. Recent e...
Science News

Researchers shed new light on RNA’s journey out of a cell’s nucleus

Cells secure DNA within their nuclei like a secret code stashed in a vault. However, the tightly controlled borders of the nucleus create a challenge: In order for the cell to produce essential proteins, messages derived from DNA must somehow escape the nucleus in the form of RNA molecules. New w...
Science News

A possible explanation for why male mice tolerate stress better than females

The nerves we feel before a stressful event—like speaking in public, for example—are normally kept in check by a complex system of circuits in our brain. Now, scientists at Rockefeller University have identified a key molecule within this circuitry that is responsible for relieving anxiety. Intr...
Awards and Honors

Rockefeller graduate Monica Mugnier wins 2016 NIH Early Independence Award

Monica Mugnier, who completed her Ph.D. at Rockefeller earlier this year, is one of 16 junior investigators nationwide to receive a National Institutes of Health Director’s Early Independence Award. The award, which is part of the NIH’s High-Risk, High-Reward Research program, allows early-caree...
Science News

Study explains how an intestinal microbe protects against other, more dangerous bacteria

Antibiotics save millions of lives. But their tendency to kill helpful and harmful bacteria alike, coupled with the growing problem of antibiotic resistance, means that they are not without their downside. Probiotics consisting of beneficial microorganisms, meanwhile, have the potential to delive...
Science News

New research clarifies how cells take in cholesterol and offers insight on Ebola

Cholesterol—that waxy substance incriminated in heart attack and stroke—is a precious commodity for cells. In fact, errors in a cell’s ability to import these rod-like molecules can be fatal. In new work, researchers at The Rockefeller University and their colleagues delved into a pivotal p...
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