Scientists studying the cell’s DNA-copying machinery have discovered a molecular mechanism that helps reactivate it should it stop prematurely. Its function may prevent genetic errors like those that cause cancer.
Scientists have discovered a group of brain cells that may play a role in keeping smokers addicted to nicotine. Their work could ultimately lead to new drugs to help people conquer their tobacco dependence.
Nussenzweig was honored at a ceremony today at the Institut Pasteur in Paris.The award recognizes investigators for past or ongoing work demonstrating real scientific progress in the life sciences.
Young was honored for his discoveries of molecular mechanisms controlling the circadian rhythm. He accepted the Nobel medal and diploma from King Carl XVI Gustaf of Sweden.
Researchers have found that the cells directing the very first steps of brain formation are not other neurons, as scientists have long assumed. They've also uncovered previously hidden molecular pathways that attract neurons into the brain.
Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They’ve used it to clarify what drives these tumors at the molecular level, and discover new drug concepts.
Scientists have discovered a peculiarity in the genetic code of HIV that might explain how this and other viruses evolved ways to dodge our immune system. The findings could make it possible to develop safer vaccines.
Scientists have identified a protein that many viruses require to spread within a host—a discovery that could lead to fighting diseases as varied as parainfluenza, West Nile, and Zika with a single drug. This finding could also lead to the development of treatments for emerging viruses.
Scientists found that inhibiting a regulatory protein alters the intricate signaling chemistry that is responsible for many of the disease’s symptoms. The findings provide a path to possible therapeutics for disorders associated with Fragile X.
Scientists have found that stem cells in the skin remember an injury, helping them close recurring wounds faster. The discovery could advance research and treatment of psoriasis and other inflammatory diseases.
Rockefeller University biologist Michael W. Young, who studies the biological clocks that regulate sleep, metabolism, and response to disease, is this year’s recipient of the Nobel Prize in Physiology or Medicine.
In the rats that roam New York City’s streets and tunnels, scientists have found a virus that resembles hepatitis C. They have used it to create the first animal model of the human disease, a breakthrough that potentially could yield a much-needed vaccine.
Allis has received the March of Dimes Prize in Developmental Biology. The award, given to investigators whose research offers hope for the prevention and treatment of birth defects and other infant diseases, honors Allis for his groundbreaking work on gene regulation.
Scientists have long seen parallels between healing wounds and growing tumors. In studying the molecular changes that occur within both, a research team has discovered a new cancer-fuelling mechanism that potentially could inform drug development.
Researchers have identified a molecule that guides the formation of eggs and sperm by preventing a host of factors related to cell death and inflammation from killing the precursors to these cells. Their findings reveal new knowledge about how a mutation in this molecule leads to male sterility.
Some viruses can insert their genetic material into the genome of their host, creating a genetic fossil record. Researchers have uncovered how our ancestors may have wiped out one such virus around 11 million years ago.
The centromere region of chromosomes retains the same DNA from one generation to the next. Scientists have gained new insights into how it avoids being scrambled in normal cells, and how it becomes unstable in cancer.
Scientists have discovered a common mutation that might explain why some people have trouble going to sleep at night and getting up early. The gene alteration slows the internal biological clock that regulates our sleeping patterns.
Researchers have found that the bacterial immune system targets an invading virus as soon as it enters the cell. This discovery answers a long-standing question about how microbes defend themselves.
Two new technologies are helping scientists understand new aspects of organ and nervous system development in C. elegans. One allows them to image worms developing in a natural environment, while the other makes it possible to track single neurons as the worms grow.
There are more than 25 drugs to control HIV, yet the virus remains one of the world’s biggest health problems. One of the many challenges with existing therapies is that a dormant version of the virus is always lurking in the background, ready to attack the immune system as soon as treatment is i...
New findings from Rockefeller University researchers could guide the development of potent combination therapies that deliver more effective and durable treatment of leukemia. In recent work published in Nature, they show it’s possible to deactivate cellular programs involved in tumor growth by d...
