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High Throughput and Spectroscopy Resource Center

High Throughput Screening (HTS) is an important step in the discovery of new medicines and involves the miniaturization and automation of bioassays so that millions of compounds can be tested. The High Throughput and Spectroscopy Resource Center (HTSRC) supports researchers in improving the efficiency of their bioassays, identifying compounds and genetic modulators of function, and in utilizing core technologies typically applied to biochemical analysis. The center has a collection of 389,728 compounds, automated liquid transfer devices, compound databases, and supports a broad diversity of assay development techniques, typically found in early drug discovery programs.

Link to HTSRC 2018 Annual Report

Link to HTSRC Assay Development Guide

The Center also has spectroscopic and calorimetric equipment for use in studies of the structure, function and interactions of biological and organic molecules.

The HTS Process


The HTSRC provides scientific and technical support and access to instrumentation in the following areas:

    • assay cascades used in drug discovery projects
    • miniaturized assay development
    • high throughput liquid handling
    • high-throughput screening
    • identifying tool compounds or lead compounds for drug discovery
    • determination of structure activity relationships/medicinal chemistry efforts
    • measuring the kinetics and thermodynamics of biomolecular interactions
    • analysis of small molecular weight compound structure and purity

Initiating a project with us

If you are interested in setting up an HTS/drug discovery project or utilizing our spectroscopic instruments please contact Assay development and screening typically require a significant financial and time commitment and advance discussions are needed to prepare for the project. This resource center is a shared facility supported by Weill-Cornell Medical College and Rockefeller University, and we welcome clients from those institutions. Due to a high demand for our services, we can  accept projects from outside institutions only on a case-by-case basis. The HTSRC does not currently support research in conjunction with for-profit entities.

Assay Flow Chat