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High-Throughput and Spectroscopy Resource Center

High-Throughput Screening (HTS) is an important step in the discovery of new medicines and involves the miniaturization and automation of bioassays so that millions of compounds can be tested.  The High-Throughput and Spectroscopy Resource Center (HTSRC) supports researchers in improving the efficiency of their bioassays, identifying compounds and genetic modulators of function, and in utilizing core technologies typically applied to biochemical analysis.  The center has a collection of 376,500 compounds, automated liquid transfer devices, compound databases, and supports a broad diversity of assay development techniques, typically found in early drug discovery programs.

The  Center also has spectroscopic and calorimetric equipment for use in studies of the structure, function and interactions of biological and organic molecules.

The HTS Process

 

The HTSRC provides scientific and technical support and access to instrumentation in the following areas:

  • assay cascades used in drug discovery projects
  • miniaturized assay development
  • high throughput liquid handling
  • high-throughput screening
  • identifying tool compounds or lead compounds for drug discovery
  • determination of structure activity relationships/medicinal chemistry efforts
  • measuring the kinetics and thermodynamics of biomolecular interactions
  • analysis of small molecular weight compound structure and purity

If you are interested in setting up an HTS/drug discovery project or utilizing our spectroscopic instruments please contact htsrc@rockefeller.edu. Assay development and screening typically require a significant financial and time commitment and advance discussions are needed to prepare for the project. This resource center is a shared facility supported by Weill-Cornell Medical College and Rockefeller University, and we welcome clients from those institutions. Due to a high demand for our services, we can only accept projects from outside institutions on a case-by-case basis.  The HTSRC does not currently support research in conjunction with for-profit entities.

Assay Flow Chat


Contact

The Rockefeller University
Box 203
1230 York Ave
New York, NY 10065

High-Throughput Screening Resource Center
Bronk Laboratory
DWB Room 216