Microplate Readers

Biotek Synergy NEO
Multi-function microplate reader: Fluorescence polarization, time-gated fluorescence, prompt fluorescence, luminescence, alphascreen
384 compounds / 2 minutes with a monochromator-based optical system and a dual reagent dispenser for kinetic assays.

LICOR Odyssey M

The Odyssey M can be used to image Western blot membranes, nucleic acid and protein gels, multiwell-plates, and microscope slides in 18 channels including laser scanning fluorescence with 4 lasers and 9 emission channels, bio and chemi luminescence, and transmitted/epi light detection with multiplex detection and overlay capabilities. The acquisition and analysis software are very easy to use, and Licor offers support in planning or troubleshooting experiments.

Hammamatsu uCell FDSS

FDSS/μCELL is a laboratory screening system well-suited for screening based on the measurement of ion-channel activity in living cells. Simultaneous measurement and analysis of the kinetics of a sample’s fluorescence or luminescence intensity in all wells at the time of compound addition are made possible by the high sensitivity two-dimensional sensor (camera) and dispenser head (96 tip type / 384 tip type).

Perkin-Elmer Operetta

The Operetta is a “high-content screening system”, that is a fluorescence microscopy-based microplate reader with confocal optics and auto-focussing capabilities. The system can collect multi-wavelength fluorescence micrographs from microplates, storing and scoring images automatically. The instrument is particularly useful in identifying compounds with specific effects on cell morphology, protein expression or localisation.

If you are interested in setting up an HTS/drug discovery project or utilizing our spectroscopic/liquid dispensing instruments please contact ddrc@rockefeller.edu. Assay development and screening typically require a significant financial and time commitment and advance discussions are needed to prepare for the project. This resource center is a shared facility supported by Weill-Cornell Medical College and Rockefeller University, and we welcome clients from those institutions. Due to a high demand for our services, we can accept projects from outside institutions only on a case-by-case basis.  The DDRC does not currently support research in conjunction with for-profit entities.