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Found 34923 matches. Displaying 121-130
Huang YC
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Gain-of-function mutations in the UNC-2/CaV2 alpha channel lead to

ELIFE 2019 AUG 5; 8(?):? Article e45905
Mutations in pre-synaptic voltage-gated calcium channels can lead to
Frank MO
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Sequencing and curation strategies for identifying candidate

BMC MEDICAL GENOMICS 2019 AUG 2; 12(1):? Article 114
Blackmon K
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Cortical gray-white matter blurring and declarative memory impairment in

EPILEPSY & BEHAVIOR 2019 AUG; 97(?):34-43
Magnetic resonance imaging (MRI)- negative temporal lobe epilepsy (TLE)
Belkaya S
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Inherited IL-18BP deficiency in human fulminant viral hepatitis

JOURNAL OF EXPERIMENTAL MEDICINE 2019 AUG; 216(8):1777-1790
Fulminant viral hepatitis (FVH) is a devastating and unexplained
Galea S, Vaughan RD
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Public Health, Politics, and the Creation of Meaning: A Public Health of Consequence, July 2019

AMERICAN JOURNAL OF PUBLIC HEALTH 2019 JUL; 109(7):966-968
Presslee S, Slater GJ, Pujos F, Forasiepi AM, Fischer R, Molloy K, Mackie M, Olsen JV, Kramarz A, Taglioretti M, Scaglia F, Lezcano M, Lanata JL, Southon J, Feranec R, Bloch J, Hajduk A, Martin FM, Gismondi RS, Reguero M, de Muizon C, Greenwood A, Chait BT, Penkman K, Collins M, MacPhee RDE
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Palaeoproteomics resolves sloth relationships

NATURE ECOLOGY & EVOLUTION 2019 JUL; 3(7):1121-1130
The living tree sloths Choloepus and Bradypus are the only remaining members of Folivora, a major xenarthran radiation that occupied a wide range of habitats in many parts of the western hemisphere during the Cenozoic, including both continents and the West Indies. Ancient DNA evidence has played only a minor role in folivoran systematics, as most sloths lived in places not conducive to genomic preservation. Here we utilize collagen sequence information, both separately and in combination with published mitochondrial DNA evidence, to assess the relationships of tree sloths and their extinct relatives. Results from phylogenetic analysis of these datasets differ substantially from morphology-based concepts: Choloepus groups with Mylodontidae, not Megalonychidae; Bradypus and Megalonyx pair together as megatherioids, while monophyletic Antillean sloths may be sister to all other folivorans. Divergence estimates are consistent with fossil evidence for mid-Cenozoic presence of sloths in the West Indies and an early Miocene radiation in South America.
Lapointe T
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Effects of combined escitalopram and aripiprazole in rats: role of the

PSYCHOPHARMACOLOGY 2019 JUL; 236(7):2273-2281
RationalePre-clinical and clinical studies have suggested that the
Schneeberger M, Parolari L, Das Banerjee T, Bhave V, Wang P, Patel B, Topilko T, Wu Z, Choi CHJ, Yu X, Pellegrino K, Engel EA, Cohen P, Renier N, Friedman JM, Nectow AR
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Regulation of Energy Expenditure by Brainstem GABA Neurons

CELL 2019 JUL 25; 178(3):672-685.e12
Homeostatic control of core body temperature is essential for survival. Temperature is sensed by specific neurons, in turn eliciting both behavioral (i.e., locomotion) and physiologic (i.e., thermogenesis, vasodilatation) responses. Here, we report that a population of GABAergic (Vgat-expressing) neurons in the dorsolateral portion of the dorsal raphe nucleus (DRN), hereafter DRNVgat neurons, are activated by ambient heat and bidirectionally regulate energy expenditure through changes in both thermogenesis and locomotion. We find that DRNVgat neurons innervate brown fat via a descending projection to the raphe pallidus (RPa). These neurons also densely innervate ascending targets implicated in the central regulation of energy expenditure, including the hypothalamus and extended amygdala. Optogenetic stimulation of different projection targets reveals that DRNVgat neurons are capable of regulating thermogenesis through both a "direct" descending pathway through the RPa and multiple "indirect" ascending pathways. This work establishes a key regulatory role for DRNVgat neurons in controlling energy expenditure.
Penas C, Maloof ME, Stathias V, Long J, Tan SK, Mier J, Fang Y, Valdes C, Rodriguez-Blanco J, Chiang CM, Robbins DJ, Liebl DJ, Lee JK, Hatten ME, Clarke J, Ayad NG
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Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis

NATURE COMMUNICATIONS 2019 JUL 10; 10(?):? Article 3028
Cerebellar neuronal progenitors undergo a series of divisions before irreversibly exiting the cell cycle and differentiating into neurons. Dysfunction of this process underlies many neurological diseases including ataxia and the most common pediatric brain tumor, medulloblastoma. To better define the pathways controlling the most abundant neuronal cells in the mammalian cerebellum, cerebellar granule cell progenitors (GCPs), we performed RNA-equencing of GCPs exiting the cell cycle. Time-series modeling of GCP cell cycle exit identified downregulation of activity of the epigenetic reader protein Brd4. Brd4 binding to the Gli1 locus is controlled by Casein Kinase 1 delta (CK1 delta)-dependent phosphorylation during GCP proliferation, and decreases during GCP cell cycle exit. Importantly, conditional deletion of Brd4 in vivo in the developing cerebellum induces cerebellar morphological deficits and ataxia. These studies define an essential role for Brd4 in cerebellar granule cell neurogenesis and are critical for designing clinical trials utilizing Brd4 inhibitors in neurological indications.
Castner J, Mammen MJ, Jungquist CR, Licata O, Pender JJ, Wilding GE, Sethi S
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Validation of fitness tracker for sleep measures in women with asthma

JOURNAL OF ASTHMA 2019 JUL 3; 56(7):719-730
Objective: Nighttime wakening with asthma symptoms is a key to assessment and therapy decisions, with no gold standard objective measure. The study aims were to (1) determine the feasibility, (2) explore equivalence, and (3) test concordance of a consumer-based accelerometer with standard actigraphy for measurement of sleep patterns in women with asthma as an adjunct to self-report. Methods: Panel study design of women with poorly controlled asthma from a university-affiliated primary care clinic system was used. We assessed sensitivity and specificity, equivalence and concordance of sleep time, sleep efficiency, and wake counts between the consumer-based accelerometer Fitbit Charge (TM) and Actigraph wGT3X+. We linked data between devices for comparison both automatically by 24-hour period and manually by sleep segment. Results: Analysis included 424 938 minutes, 738 nights, and 833 unique sleep segments from 47 women. The fitness tracker demonstrated 97% sensitivity and 40% specificity to identify sleep. Between device equivalence for total sleep time (15 and 42-minute threshold) was demonstrated by sleep segment. Concordance improved for wake counts and sleep efficiency when adjusting for a linear trend. Conclusions: There were important differences in total sleep time, efficiency, and wake count measures when comparing individual sleep segments versus 24-hour measures of sleep. Fitbit overestimates sleep efficiency and underestimates wake counts in this population compared to actigraphy. Low levels of systematic bias indicate the potential for raw measurements from the devices to achieve equivalence and concordance with additional processing, algorithm modification, and modeling. Fitness trackers offer an accessible and inexpensive method to quantify sleep patterns in the home environment as an adjunct to subjective reports, and require further informatics development.