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Fisher Center for Alzheimer's Disease Research

The Fisher Center is a nexus for Alzheimer’s disease research at Rockefeller. Its scientists work to expand and accelerate Alzheimer’s research and lay the foundation for new treatment strategies. In particular, the Fisher Center’s investigations build on research that explores various aspects of the disease including: 1) the processing of amyloid precursor protein (APP) that contributes to amyloid plaque formation; 2) the regulation of presenilin1, one of the two major enzymes involved in the processing of APP; 3) the identification and characterization of genomic differences between nerve cells that are vulnerable and those that are resistant to the disease; 4) the evaluation of the importance of microglia in the disease; and 5) attempts to create in vitro stem cells (iPSCs) corresponding to the nerve cells that are most vulnerable in the disease.