Publications

Last five (5) years of published articles are listed below.

Click here for Elaine Fuchs’ full publication list.

1. Tierney MT, Polak L, Yang Y, Abdusselamoglu MD, Baek I, Stewart KS, Fuchs E. “Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices.” Science 383(6687)(2024).
2. Yuan S, Almagro J, Fuchs E. “Beyond genetics: driving cancer with the tumour microenvironment behind the wheel.” Nat Reviews Cancer DOI: https://doi.org/10.1038/s41568-023-00660-9(2024).
3. Stewart KS, Gonzales KA, Yuan S, Tierney MT, Bonny AR, Yang Y, Infarinato NR, Cowley CJ, Levorse JM, Pasolli HA, Ghosh S, Rothlin CV, Fuchs E. “Stem cells tightly regulate dead cell clearance to maintain tissue fitness.” bioRxiv DOI: doi: 10.1101/2023.05.22.541773(2023).
4. Yang Y, Gomez N, Infarinato N, Adam RC, Sribour M, Baek I, Laurin M, Fuchs E. “The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates.” Nat Cell Biol DOI: https://doi.org/10.1038/s41556-023-01184-y (2023).
5. Liu S, 1 7, Hur Y-H, Cai X, Cong Q, Yang Y, Xu C, Bilate AM, Gonzales KAU,Parigi SM,Cowley CJ, Hurwitz B, Luo J-D, Tseng T, Gur-Cohen S, Sribour M, Omelchenko T, Levorse J, Pasolli HA, Thompson CB, Mucida D, Fuchs E. “A tissue injury sensing and repair pathway distinct from host pathogen defense.” Cell 186:1-17 DOI: https://doi.org/10.1016/j.cell.2023.03.031 (2023).
6. Sajjath S, Gola A, Fuchs E. “Designer bugs as cancer drugs?” Science 380(6641):132-1333 DOI: 10.1126/science.adh3884 (2023).
7. Yuan S, Stewart KS, Yang Y, Abdusselamoglu MD, Parigi SM, Feinberg TY, Tumaneng K, Yang H, Levorse JM, Polak L, Ng D, Fuchs E. “Ras drives malignancy through stem cell crosstalk with the microenvironment.” Nature DOI: 10.1038/s41586-022-05475-6 (2022).
8. Hurwitz B, Guzzi N, Gola A, Fiore VF, Sendoel A, Nikolova M, Barrows D, Carroll TS, Pasolli HA, Fuchs E. “The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress.” Elife 11:e77780 DOI: 10.7554/eLife.77780 (2022).
9. Naik S, Fuchs E. “Inflammatory memory and tissue adaptation in sickness and in health.” Nature 607(7918):249-255 DOI: 607(7918):249-255 (2022).
10. Niec RE, Chu T, Schernthanner M, Gur-Cohen S, Hidalgo L, Pasolli HA, Luckett KA, Wang Z, Bhalla SR, Cambuli F, Kataru RP, Ganesh K, Mehrara BJ, Pe’er D, Fuchs E. “Lymphatics act as a signaling hub to regulate intestinal stem cell activity.” Cell Stem Cell 29(7):1067-1082.e18. DOI: 10.1016/j.stem.2022.05.007 (2022).
11. Niec RE, Rudensky AY, Fuchs E.”Inflammatory adaptation in barrier tissues.” Cell 184(13):3361-3375. DOI: 10.1016/j.cell.2021.05.036 (2021).
12. Gonzales KAU, Polak L, Matos I, Tierney MT, Gola A, Wong E, Infarinato NR, Nikolova M, Luo S, Liu S, Novak JSS, Lay K, Pasolli HA, Fuchs E. “Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories.” Science 374(6571). DOI: 10.1126/science.abh2444 (2021).
13. Larsen SB, Cowley CJ, Sajjath SM, Barrows D, Yang Y, Carroll TS, Fuchs E. “Establishment, maintenance, and recall of inflammatory memory.” Cell Stem Cell. doi: 10.1016/j.stem.2021.07.001. (2021).
14. Infarinato NR, Stewart KS, Yang Y, Gomez NC, Pasolli HA, Hidalgo L, Polak L, Carroll TS, Fuchs E.”BMP signaling: at the gate between activated melanocyte stem cells and differentiation.” Genes Dev DOI: 10.1101/gad.340281.120 [Epub ahead of print] (2020).
15. Fiore VF, Krajnc M, Quiroz FG, Levorse J, Pasolli HA, Shvartsman SY, Fuchs E.”Mechanics of a multilayer epithelium instruct tumour architecture and function.” Nature DOI: 10.1038/s41586-020-2695-9 [Epub ahead of print] (2020).
16. Xi L, Carroll T, Matos I, Luo JD, Polak L, Pasolli HA, Brüning JC, Jaffrey SR, Fuchs E. ”m6A RNA methylation impacts fate choices during skin morphogenesis.” eLife DOI: 10.7554/eLife.56980 [Epub ahead of print] (2020).
17. Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, Novak JSS, Tierney MT, Dela Cruz-Racelis J, Fuchs E, Finley LWS. ”Extracellular serine controls epidermal stem cell fate and tumour initiation.” Nat Cell Biol DOI: 10.1038/s41556-020-0525-9 [Epub ahead of print] (2020).
18. Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. ” NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices.” Nat Cell Biol DOI: 10.1038/s41556-020-0513-0 [Epub ahead of print] (2020).
19. Matos I, Asare A, Levorse J, Ouspenskaia T, de la Cruz-Racelis J, Schuhmacher LN, Fuchs E. ” Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development.” eLife DOI: 10.7554/eLife.54304 (2020).
20. Garcia Quiroz, F, Fiore VF, Levorse J, Polak L, Wong E, Pasolli HA, Fuchs E.” Liquid-liquid phase separation drives skin barrier formation.” Science 367(6483) (2020).
21. Ge Y, Miao Y, Gur-Cohen S, Gomez N, Yang H, Nikolova M, Polak L, Hu Y, Verma A, Elemento O, Krueger JG, Fuchs E. “The aging skin microenvironment dictates stem cell behavior.” Proc Natl Acad Sci U S A. 117(10):5339-5350 (2020).
22. Larsen SB, Cowley CJ, Fuchs E.“Epithelial cells: liaisons of immunity.” Curr Opin Immunol 62:45-53. DOI: 10.1016/j.coi.2019.11.004 (2019).
23. Gur-Cohen S, Yang H, Baksh SC, Miao Y, Levorse L, Kataru RP, Liu X, de la Cruz-Racelis J, Mehrara BJ, Fuchs E. “Stem cell–driven lymphatic remodeling coordinates tissue regeneration.” Science DOI: 10.1126/science.aay4509 (2019).
24. Laurin M, Gomez NC, Levorse J, Sendoel A, Sribour M, Fuchs EF. “An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis.” eLIFE DOI: 10.7554/eLife.50226 (2019).
25. Ellis SJ, Gomez NC, Levorse J, Mertz AF, Ge Y, Fuchs E. “Distinct modes of cell competition shape mammalian tissue morphogenesis.” Nature 569(7757):497-502 (2019).