Publications

Elaine Fuchs, Ph.D.

Rebecca C. Lancefield Professor
Investigator, Howard Hughes Medical Institute

Last five (5) years of published articles are listed below.

Click here for Elaine Fuchs’ full publication list.

  1. Novak JSS, Polak L, Baksh SC, Barrows DW, Schernthanner M, Jackson BT, Thompson EAN, Gola A, Abdusselamoglu MD, Bonny AR, Gonzales KAU, Brunner JS, Bridgeman AE, Stewart KS, Hidalgo L, Dela Cruz-Racelis J, Luo JD, Gur-Cohen S, Pasolli HA, Carroll TS, Finley LWS, Fuchs E. “The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury.” Cell Metab. 2025 Aug 5;37(8):1715-1731.e11. doi: 10.1016/j.cmet.2025.05.010 (2025).
  2. Kudelka MR, Lavin Y, Sun S, Fuchs E. “Molecular and cellular dynamics of squamous cell carcinomas across tissues.” Genes Dev. 2025 Jan 7;39(1-2):18-35. doi: 10.1101/gad.351990.124 (2024).
  3. Fiore VF, Almagro J, Fuchs E. “Shaping epithelial tissues by stem cell mechanics in development and cancer.” Nat Rev Mol Cell Biol. 2025 Jan 29;26(6):442-455. doi: 10.1038/s41580-024-00821-0 (2025).
  4. Stewart KS, Gonzales KA, Yuan S, Tierney MT, Bonny AR, Yang Y, Infarinato NR, Cowley CJ, Levorse JM, Pasolli HA, Ghosh S, Rothlin CV, Fuchs E. “Stem cells tightly regulate dead cell clearance to maintain tissue fitness.” Nature DOI: https://doi.org/10.1038/s41586-024-07855-6(2024).
  5. Tierney MT, Polak L, Yang Y, Abdusselamoglu MD, Baek I, Stewart KS, Fuchs E. “Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices.” Science 383(6687)(2024).
  6. Yuan S, Almagro J, Fuchs E. “Beyond genetics: driving cancer with the tumour microenvironment behind the wheel.” Nat Reviews Cancer DOI: https://doi.org/10.1038/s41568-023-00660-9(2024).
  7. Yang Y, Gomez N, Infarinato N, Adam RC, Sribour M, Baek I, Laurin M, Fuchs E. “The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates.” Nat Cell Biol DOI: https://doi.org/10.1038/s41556-023-01184-y (2023).
  8. Liu S, 1 7, Hur Y-H, Cai X, Cong Q, Yang Y, Xu C, Bilate AM, Gonzales KAU,Parigi SM,Cowley CJ, Hurwitz B, Luo J-D, Tseng T, Gur-Cohen S, Sribour M, Omelchenko T, Levorse J, Pasolli HA, Thompson CB, Mucida D, Fuchs E. “A tissue injury sensing and repair pathway distinct from host pathogen defense.” Cell 186:1-17 DOI: https://doi.org/10.1016/j.cell.2023.03.031 (2023).
  9. Sajjath S, Gola A, Fuchs E. “Designer bugs as cancer drugs?” Science 380(6641):132-1333 DOI: 10.1126/science.adh3884 (2023).
  10. Yuan S, Stewart KS, Yang Y, Abdusselamoglu MD, Parigi SM, Feinberg TY, Tumaneng K, Yang H, Levorse JM, Polak L, Ng D, Fuchs E. “Ras drives malignancy through stem cell crosstalk with the microenvironment.” Nature DOI: 10.1038/s41586-022-05475-6 (2022).
  11. Hurwitz B, Guzzi N, Gola A, Fiore VF, Sendoel A, Nikolova M, Barrows D, Carroll TS, Pasolli HA, Fuchs E. “The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress.” Elife 11:e77780 DOI: 10.7554/eLife.77780 (2022).
  12. Naik S, Fuchs E. “Inflammatory memory and tissue adaptation in sickness and in health.” Nature 607(7918):249-255 DOI: 607(7918):249-255 (2022).
  13. Niec RE, Chu T, Schernthanner M, Gur-Cohen S, Hidalgo L, Pasolli HA, Luckett KA, Wang Z, Bhalla SR, Cambuli F, Kataru RP, Ganesh K, Mehrara BJ, Pe’er D, Fuchs E. “Lymphatics act as a signaling hub to regulate intestinal stem cell activity.” Cell Stem Cell 29(7):1067-1082.e18. DOI: 10.1016/j.stem.2022.05.007 (2022).
  14. Niec RE, Rudensky AY, Fuchs E.”Inflammatory adaptation in barrier tissues.” Cell 184(13):3361-3375. DOI: 10.1016/j.cell.2021.05.036 (2021).
  15. Gonzales KAU, Polak L, Matos I, Tierney MT, Gola A, Wong E, Infarinato NR, Nikolova M, Luo S, Liu S, Novak JSS, Lay K, Pasolli HA, Fuchs E. “Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories.” Science 374(6571). DOI: 10.1126/science.abh2444 (2021).
  16. Larsen SB, Cowley CJ, Sajjath SM, Barrows D, Yang Y, Carroll TS, Fuchs E. “Establishment, maintenance, and recall of inflammatory memory.” Cell Stem Cell. doi: 10.1016/j.stem.2021.07.001. (2021).

    17.  

News

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Researchers used a combination of wet lab research and deep machine learning to pinpoint distinct genetic sequences, work that could inform therapeutic strategies for chronic inflammation.

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Long thought to serve as cellular scaffolding, microtubules also reshape the proteins that bind to them—guiding enzyme activity to prevent genetic errors linked to cancer.

How ants distinguish friend from foe

Researchers find that ants continually update their sense of nestmate identity and tolerance for outsiders, a discovery that opens the door to studying the neural circuits behind social recognition.

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