News & HighlightsNews
In brief: Mutation explains why some people are more vulnerable to viral brain infection
...Rockefeller’s Jean-Laurent Casanova has identified mutations in a single gene that may explain what goes wrong in cases of encephalitis of the brain stem, the part of the brain that controls many basic functions including heart rate and breathing. Shen-Ying Zhang, assistan...
In the News - Newsweek - Casanova
...Jean-Laurent Casanova, a professor at Rockefeller University who studies how genetic coding can make a person more susceptible to disease. 'If we continue to rely solely on antibiotics, we are going to have a problem.'"
Researchers uncover molecular mechanisms of rare skin disease
...Led by Rockefeller scientist Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, a group of researchers recently elucidated the molecular mechanisms that make people with EV vulnerable to ß-HPVs. In a new study, published in th...
Patient with unusually severe infection leads scientists to a rare type of immune deficiency
...An unexpected life-threatening infectious disease that is not explained by a compromised immune system often turns out to be a genetic disorder,” says lead investigator Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at Rock...
Llamas immune to coronavirus, what zebrafish are thinking, and other memorable science stories of 2020 
...Shortly thereafter, Jean-Laurent Casanova and colleagues made headlines with two reports revealing that people with the most severe cases of the disease frequently lack interferon I, a cluster of proteins that repel viruses, providing the first molecular explanation for wh...
Study pinpoints rare genetic change that may boost risk of HPV-related illness
...We’ve cracked the enigma of why the boys developed these warts,” says lead investigator Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases. The findings add to a growing body of evidence that is changing how researchers think a...
Genetic mutation identified as culprit in rare infectious disease
...In an article published in eLife, Jean-Laurent Casanova has uncovered the human genetics factors that make these outliers susceptible to infection. His team suspected that Whipple’s is the latest in a growing number of genetic defects that increases people’s vulnerability ...
Milestones
...Jean-Laurent Casanova, the 2011 InBev-Baillet Latour Health Prize, Beligum’s highest scientific honor. With a value of 250,000 euros, the InBev-Baillet prize recognizes the practical application of basic research; Dr. Casanova is honored for his work on the identifi...
Awards, arrivals, and promotions
Congratulations to our latest award winners: Jean-Laurent Casanova has been recognized with the Stanley J. Korsmeyer Award for his work investigating the genetic basis of pediatric infectious diseases. The award is given by the American Society for Clinical Investigation, an ...
Researchers develop gene-filtering tool to identify disease-causing mutations
...A new tool, developed by scientists in Jean-Laurent Casanova’s St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller University aims to predict whether a given human gene is likely to harbor disease-causing mutations. The hope is that their tool, des...
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