News & HighlightsNews
The genetic underpinnings of severe staph infections
...Rockefeller immunologist Jean-Laurent Casanova examined the protein-coding genomes of more than 100 patients who had suffered from unexplained severe staph infections. The common genetic thread linking some of th...
How one patient’s rare mutation helped solve a mycobacterial mystery
...The lab of Jean-Laurent Casanova, which has spent 25 years studying the interplay between human genes and mycobacterial disease, continues to uncover the genetic defects that separate those who develop serious infections from those who remain symptomless after being expose...
Rockefeller scientists launch a broad range of studies into novel coronavirus
...Rockefeller’s Jean-Laurent Casanova is the world leader in identifying gene mutations responsible for extreme variations in infectious disease outcomes. This research can identify human genes that are essential for resisting viral infection or whose mutation prevents the v...
Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19
...We may find a genetic clue that could help explain what is driving this severe complication in these children, which can in turn inform their clinical care,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockef...
Jean-Laurent Casanova honored with Belgium’s highest scientific prize
Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller University, has received the 2011 InBev-Baillet Latour Health Prize for his pioneering work on the identification of genes that predispose for human i...
The gene hunt to explain why some young, healthy people die from COVID-19
...Infectious diseases are always an interplay between a pathogen and the host’s immunity,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University. “At least some of these patients may suffer from a ...
Jeffrey V. Ravetch to receive 2018 Robert Koch Award
...Rice in 2015 for studies of the hepatitis C virus, Jean-Laurent Casanova in 2014 for work on genetic susceptibility to infectious disease, and Ralph Steinman in 1999 for discovering dendritic cells and their influence on immunity. René Jules Dubos was the first Rockefeller...
Scientists trace severe COVID-19 to faulty genes and autoimmune condition
...These findings provide compelling evidence that the disruption of type I interferon is often the cause of life-threatening COVID-19,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University and a H...
Researchers find genetic link to tuberculosis
...Now, Rockefeller scientist Jean-Laurent Casanova has identified a genetic condition that makes the immune system susceptible to mycobacterial attack. Last year, Casanova showed that the risk of developing TB is heightened in people who have two copies of a particula...
Patient with unusually severe infection leads scientists to a rare type of immune deficiency
...An unexpected life-threatening infectious disease that is not explained by a compromised immune system often turns out to be a genetic disorder,” says lead investigator Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at Rock...
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