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Shapeshifting receptors may explain mysterious drug failures

Scientists have found that many receptors with high potential for drug discovery take a different configuration inside the body than in the test tube. The findings could explain why some promising drugs fail in clinical trials, and potentially open doors to new drug-development approaches.

Tips for a greener lab

Even the most routine scientific experiment may come with a hefty environmental footprint. Here are several best practices to reduce waste, save energy, and cultivate more planet-friendly lab habits.

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Vanessa Ruta named a 2019 MacArthur Fellow

Ruta, who investigates how the brain is modified by experience, has received a MacArthur Fellowship, an award intended to encourage people of outstanding talent to pursue their own creative, intellectual, and professional inclinations.

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Study gives clues to the origin of Huntington’s disease, and a new way to find drugs

Using a new technique to study brain development, scientists were able to trace the causes of Huntington's back to early developmental stages when the brain has only just begun to form.

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Jeffrey M. Friedman to receive 2020 Breakthrough Prize in Life Sciences

Friedman's discovery of the hormone leptin has transformed our understanding of obesity.

Recent donations establish centers for computational science and for metabolism, and renew resources for faculty recruitment

The university’s Campaign for Transforming Biomedicine—which raised $1.17 billion over eight years—closed this summer with a bang: three significant capstone gifts, made in the campaign’s final months, to directly support Rockefeller science.

Becoming a Scientist: Priya Rajasethupathy 

Memories are inherently shifty. A neuroscientist with a new lab of her own, Rajasethupathy likens the brain’s memory function to Wikipedia—always evolving, occasionally unreliable.

From the tiny testes of flies, new insight into how genes arise

A common birthplace of new genes, the male testes are a hotspot for biological innovation. Within these organs, scientists have found a trove of virgin genetic sequences—and a better understanding of how evolution moves forward.

Findings shed new light on why Zika causes birth defects in some pregnancies

Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.

With tiny technological tweezers, researchers uncover new aspects of cell division

Cell division is critical to creating and sustaining life. It’s also incredibly difficult to study. Now, advanced technology is enabling researchers to take their understanding of this process to the next level.

Recent Awards and Honors

Junyue Cao

Junyue Cao wins Science & SciLifeLab Grand Prize For Young Scientists

November 19, 2020

Cao is recognized for his work using single-cell genomic methods to enable developmental mapping of entire organisms, described in an essay published in Science.
LLuciano Marraffini portrait

Luciano Marraffini awarded Max Planck-Humboldt Medal

October 14, 2020

Marraffini receives the award for his achievements studying CRISPR-Cas, a bacterial immune mechanism whose discovery led to modern gene-editing tools.
More awards and honors

Rockefeller in the News

The Scientist

Paul Cohen of the Rockefeller University describes his study of thousands of people, finding that the energy-burning tissue is tied to a lower risk of for several diseases, including type 2 diabetes, high blood pressure, and heart disease.

The Wall Street Journal

The Rockefeller team found that the E484K mutation knocked out one important class of antibodies, out of a total of four classes. But Dr. Nussenzweig said that other elements of a person’s immune response—whether triggered by a vaccine or an earlier infection—could still protect against Covid-19.

Nature News

An innovative approach from Priya Rajasethupathy has been used to link genetics to behavior in mice. The analysis identifies a gene that underpins the role of the brain’s thalamus region in maintaining short-term memory.

Seek magazine

Rockefeller’s flagship publication is interested not just in scientific results, but in the people, ideas, and conversations that ignite discovery. The latest issue takes us inside the response to the pandemic, where scientists are using every tool in the 21st century playbook to transform COVID-19 into a manageable disease. Also: Mosquito menace, The brain inside your gut, and Addiction then and now.


From this issue

 


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