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Life's inner mechanics 

Cells—and the molecules inside them—are always on the move. They’re being tugged at, prodded, reshuffled. Behind these actions are tiny forces that, after decades of neglect, are emerging as the next big thing in biology.

Will SARS-CoV-2 escape future drugs by mutating? The answer may be a nuanced “no.”

Scientists hope to deploy antibodies in the quest to end COVID-19. A recent study moves them closer to accomplishing a key step: finding out if the virus may acquire resistance to antibody-based drugs or vaccines, and how to potentially prevent this.


A never-before-seen image of the coronavirus copy machine

The high-resolution 3D image can speed COVID-19 drug discovery.

How toothless mock viruses could advance research on COVID-19

Scientists have engineered four viruses resembling SARS-CoV-2 to enable faster and safer research on vaccines and treatments.

Bacteria in the gut have a direct line to the brain

Scientists find that microbes inside the intestines can control the activities of neurons connecting the gut and brain.

Amid the rush for COVID-19 drugs, a case for the helicase

The enzyme is essential for the virus to replicate itself inside our cells. Scientists already have ideas for how to block it.

How neurons in body fat grow to boost calorie-burning capacity

Scientists have found that a hormone tells the brain to dramatically restructure neurons embedded in fat tissue.  Their work widens our understanding of how the body regulates its energy consumption, and how obesity might be treated in the future.

Becoming a Scientist: Jeanne Garbarino 

Meet Jeanne Garbarino, the scientist whose job it is to get teens out of their textbooks and into the lab.

Novel cells might act as a warning sign for rheumatoid arthritis flares

A genomics study has identified a previously unknown cell type whose blood levels tend to rise and fall in patients with rheumatoid arthritis. The findings could make it easier to manage the disease and help scientists understand its root causes.

Interview: Mary Jeanne Kreek 

Thousands of years after humans discovered opioids, we’re just beginning to understand how these substances warp the brain and change behaviors.

Recent Awards and Honors

Charles M. Rice

Charles M. Rice is elected to the National Academy of Inventors

December 7, 2021

Rice receives the honor for pioneering novel methods for growing and studying hepatitis C virus.

Kivanç Birsoy receives ASCB Innovation in Research Award

November 30, 2021

Birsoy is recognized for examining how human cells alter their uptake and use of nutrients to adapt to stress.

More awards and honors

Rockefeller in the News

NPR

The vaccines will likely be less effective against this variant, he predicts. But Paul Bieniasz's research so far also suggests that people can boost their protection — against any variant — by having three exposures to the virus. So that means either three doses of the vaccine or two doses after a natural infection.

CNN

Rockefeller's Elizabeth Campbell explains that Merck's antiviral drug works by wreaking havoc with the way the Covid-19 virus makes copies of itself. She cautions that the potential off-target effects will require further investigation.

The Scientist

In mice, a kind of immune memory appears to protect the cells against future harm, a finding from Daniel Mucida that could provide insight into treatments for irritable bowel syndrome and other inflammatory digestive conditions.

Seek magazine

Rockefeller’s flagship publication is interested not just in scientific results, but in the people, ideas, and conversations that ignite discovery. The latest issue takes a look at how the brain’s internal states drive its remarkable ability to reach different conclusion based on the same information. Also: The latest from Rockefeller’s COVID labs, and much more.


From this issue

 


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