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Displaying 1172 of 2860 articles.

New study points the way to therapy for rare cancer that targets the young

Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. They’ve used it to clarify what drives these tumors at the molecular level, and discover new drug concepts.

In the fight against viral infection, spelling counts

Scientists have discovered a peculiarity in the genetic code of HIV that might explain how this and other viruses evolved ways to dodge our immune system. The findings could make it possible to develop safer vaccines.

Targeting a single protein might treat a broad range of viruses

Scientists have identified a protein that many viruses require to spread within a host—a discovery that could lead to fighting diseases as varied as parainfluenza, West Nile, and Zika with a single drug. This finding could also lead to the development of treatments for emerging viruses.

Potential new treatment for Fragile X targets one gene to affect many

Scientists found that inhibiting a regulatory protein alters the intricate signaling chemistry that is responsible for many of the disease’s symptoms. The findings provide a path to possible therapeutics for disorders associated with Fragile X.

Inflammation trains the skin to heal faster

Scientists have found that stem cells in the skin remember an injury, helping them close recurring wounds faster. The discovery could advance research and treatment of psoriasis and other inflammatory diseases.

New smell test could aid early detection of Alzheimer’s and Parkinson’s

Problems with olfaction have been linked to a variety of health conditions. Scientists have developed new tests to detect smell loss more reliably.

Stress has dramatically different effects on male and female mouse brains

Scientists have found unexpected differences in how male and female mice respond to stress. Their findings are raising big questions about sex discrepancies in the brain and their impact on neuropsychiatric disease.

Rockefeller University biologist Michael W. Young honored with Nobel Prize for pioneering studies on circadian rhythm

Rockefeller University biologist Michael W. Young, who studies the biological clocks that regulate sleep, metabolism, and response to disease, is this year’s recipient of the Nobel Prize in Physiology or Medicine.

Simple strategy could lead to a “universal” flu vaccine

To keep up with evasive flu viruses, new vaccines must be developed each year. Scientists are devising a strategy to better prevent the disease without annual shots.

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In brief: Alternative CRISPR system is less specific, more robust

Scientists found that a system called CRISPR-Cas10 can target rapidly mutating viruses.

Gut bacteria that “talk” to human cells may lead to new treatments

Scientists developed a method to genetically engineer gut bacteria to produce molecules that have the potential to treat certain disorders by altering human metabolism.

How the brain recognizes familiar faces

Scientists have located two areas in the brain that help us recognize familiar faces. The discovery will help them delve deeper into the relationship between face recognition, memory, and social knowledge.

First mutant ants shed light on evolution of social behavior

Scientists disrupted a gene essential for sensing pheromones, resulting in severe deficiencies in the ants’ social behaviors and their ability to survive within a colony.

Hunger-controlling brain cells may offer path for new obesity drugs

Within the oldest part of the brain, scientists have found cells in charge of controlling appetite and eating. The discovery could revitalize efforts to develop drugs for obesity that make us less hungry.

Faster-acting antidepressants may finally be within reach

Neuroscientists have taken a major step toward answering longstanding questions about how Prozac and similar drugs act in the brain. Their findings could lead to better antidepressants that don't take weeks to kick in.

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In brief: How a microRNA protects against liver cancer

New insights about gene regulation in liver cells could lead to better treatments for a common tumor type.

New animal models for hepatitis C could pave the way for a vaccine

In the rats that roam New York City’s streets and tunnels, scientists have found a virus that resembles hepatitis C. They have used it to create the first animal model of the human disease, a breakthrough that potentially could yield a much-needed vaccine.

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In brief: A glimpse into the origins of antibiotic resistance

Scientists have identified several genetic mechanisms by which antibiotic resistance may have arisen in a bacterium that causes deadly infections.

A hidden movement in the molecule that makes RNA

Researchers have uncovered new details about the molecular machine that separates DNA strands before copying a gene's sequence into RNA.

In brief: Mapping the errors that disrupt heartbeat

By determining the structure of a protein linked to a deadly form of arrhythmia, scientists have gained new insights about the condition.

Scientists use algorithm to peer through opaque brains

A new algorithm allows scientists to record the activity of individual neurons within a volume of brain tissue.

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In brief: A closer look at why some drugs cause arrhythmia

Scientists have identified the features that render a potassium channel in the heart vulnerable to interference by a range of drugs.

New faculty member studies the tuberculosis bacterium

Jeremy M. Rock uses genetics to investigate how the microbe causes disease. He will join Rockefeller’s faculty on January 1, 2018.

Researchers create interactive touchscreen for dolphins

To learn more about dolphin cognition and communication, researchers have developed an underwater touchscreen using optical technology, the first of its kind.

Scientists identify a neural circuit that rotates a fly’s internal compass

Researchers have uncovered the neurons that spin a fly’s internal compass when the insect turns—the first such mechanism identified in any animal.

Newly discovered brain network offers clues to social cognition

By studying rhesus monkeys, researchers have identified a brain network dedicated to processing social interactions—a discovery that offers tantalizing clues to the origins of our ability to understand what other people are thinking.

Swirling swarms of bacteria offer insights on turbulence

When bacteria swim at just the right speed, swirling vortices emerge. As those patterns disintegrate into chaos, physicists detect a telling mathematical signature.

A cell’s destiny is set earlier than expected

Stem cells in the hair follicle are organized by the cell type they will eventually become in unique compartments, at the ready to regenerate tissue.

Discovery of a Zika antibody offers hope for a vaccine

Searching for a way to thwart Zika, scientists have discovered an antibody with a potent ability to neutralize the virus.

A mechanism shared by healing wounds and growing tumors

Scientists have long seen parallels between healing wounds and growing tumors. In studying the molecular changes that occur within both, a research team has discovered a new cancer-fuelling mechanism that potentially could inform drug development.